Accuracy of Liver Fibrosis Degree Based on King’s Score to FibroScan in Chronic Hepatitis B

Marpaung, Yudi Andre; Sembiring, Juwita; Zain, Lukman Hakim

doi:10.24871/171201610-15

Cited by 2 publications

(1 citation statement)

References 4 publications

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“…On the other hand, FibroQ and King's score showed a significant positive correlation with fibrosis grade (P = 0.015 for both) and at a cutoff value of 0.085 and 0.115 respectively, both could discriminate advanced fibrosis from early fibrosis with comparable sensitivity (64.3% for both) and specificity (60.0% and 62.9% respectively). King's score has been used in assessing fibrosis in chronic hepatitis B [39] and hepatitis C [21] but no reports about its use in predicting fibrosis in BA. Combining the three scores (FIB-4, FibroQ and King's score) did not improve the performance compared to the performance of each score individually.…”

Section: Discussionmentioning

confidence: 99%

Utility of Noninvasive Serum Biomarkers of Liver Fibrosis in Infants with Biliary Atresia

Sira¹

2017

ARGH

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Background: Biliary Atresia (BA) is the most common cause of chronic cholestasis in infants It is a destructive inflammatory obliterative cholangiopathy that affects varying lengths of both intrahepatic and extrahepatic bile ducts. Even after a successful surgery, scarring of the liver can continue, resulting in cirrhosis and its complications. Aim:The aim of this study is to evaluate different serological markers derived from routine investigations in the prediction of liver fibrosis in infants with BA.Methods: This retrospective study included a total of 147 infants with proved diagnosis of BA. We employed six noninvasive scores (FIB-4, FibroQ, King's score, APRI, GUCI and AAR). Liver fibrosis was classified into 5 grades. For further descriptive purpose, we arbitrarily divided fibrosis grades into early (F1, F2 and F3) and advanced (F4 and F5) fibrosis.Results: FIB-4, FibroQ and King's score correlated significantly with fibrosis grade (P values were 0.007 and 0.015 respectively) while there was no significant correlation with other studied scores (P value >0.05). FIB-4, FibroQ and King's score were significantly higher in patients with advanced fibrosis compared to early fibrosis and at cutoff values of 0.0098, 0.0085 and 0.115 respectively they were able to discriminate those with advanced fibrosis with acceptable sensitivity (61.9%-64.3%) and specificity (60.0%-62.9%). Conclusion:FIB-4, FibroQ and King's score, but not APRI, GUCI and AAR, correlated significantly with fibrosis and could predict those with advanced fibrosis with relatively acceptable performance. These markers may be of help in predicting advanced fibrosis and in long term follow up of infants with BA and reduce the need for repeated liver biopsy.

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Section: Discussionmentioning

confidence: 99%

Utility of Noninvasive Serum Biomarkers of Liver Fibrosis in Infants with Biliary Atresia

Sira¹

2017

ARGH

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The diagnostic value of indirect markers of liver fibrosis in patients with chronic hepatitis B

Терешков

Мицура

2020

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Aim of investigation: The aim of the present study was to evaluate the possibility using of indirect liver fibrosis markers for the estimation of fibrosis severity and timely prescribing of antiviral therapy in patients with chronic hepatitis B.Materials and methods: We examined 130 patients with chronic hepatitis B (mean age 41,8±13,5 years, 70% of men) having known liver fibrosis stage based on fibroelastography or liver biopsy. The age of patients, 9 parameters of biochemical blood analysis, complete blood count and coagulogram along with 7 indices calculated on their base were considered. Their prognostic values were estimated by means of ROC analysis.Results: According to increase of liver fibrosis stage albumin, prothrombin index, platelet count, cholesterol reduce and aspartate aminotransferase, international normalized ratio, gamma-glutamyl transpeptidase, alanine aminotransferase, alkaline phosphatase levels rise (p<0,01). All of the laboratory parameters and indices were significantly different (p<0,01) in patients with minimal (F0–F1) and advanced (F2–F4) fibrosis. For patients with chronic hepatitis B the most significant predictors of advanced liver fibrosis (F2–F4) were: GUCI and King’s score indices as well as eLIFT scale. Index GUCI had the best diagnostic performance (area under the receiver operating characteristic curve 0,866) with 89,5% sensitivity and 78,0% specificity at cut off ≥0,7/ Conclusion: The assessment of indirect liver fibrosis markers in patients with chronic hepatitis B can be easily performed at any stage of medical care; they are quite informative and can be used for the estimation of fibrosis severity and timely conducting antiviral therapy.

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Accuracy of Liver Fibrosis Degree Based on King’s Score to FibroScan in Chronic Hepatitis B

Abstract: Background: A great interest has been dedicated to the development of non-invasive predictive models in

Cited by 2 publications

References 4 publications

Utility of Noninvasive Serum Biomarkers of Liver Fibrosis in Infants with Biliary Atresia

Utility of Noninvasive Serum Biomarkers of Liver Fibrosis in Infants with Biliary Atresia

The diagnostic value of indirect markers of liver fibrosis in patients with chronic hepatitis B

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