Accuracy of left ventricular ejection fraction determined by gated myocardial perfusion SPECT with Tl-201 and Tc-99m sestamibi: Comparison with first-pass radionuclide angiography

He, Zuo Xiang; Cwajg, Eduardo; Preslar, Janice S.; Mahmarian, John J.; Verani, Mario S.

doi:10.1016/s1071-3581(99)90007-7

Cited by 50 publications

(2 citation statements)

References 11 publications

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“…For detecting significant CAD, the sensitivity of the reversible regional WM abnormality is significantly higher than that of LVEF worsening (70 vs. 35%, respectively) [19]. However, the specificity of LVEF worsening was significantly higher than that of reversible regional WM abnormality (93 vs. 73%, respectively) [23]. Gated SPECT measures not only the changes in volumetric measurements but also the EDV, ESV and EF, which have recently been demonstrated in large outcome studies to be independent predictors for the prognosis of CAD [24,25,26].…”

Section: Discussionmentioning

confidence: 99%

Left Ventricular Functional Changes after Adenosine Vasodilator Stress Evaluated by Gated Single-Photon Emission Computed Tomography

Zhang

Tian²,

Zhang³

et al. 2013

Cardiology

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Objectives: Gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging is useful in assessing left ventricular (LV) myocardial perfusion and function. This study evaluated the LV functional changes after adenosine vasodilator stress, using gated SPECT. Methods: The study population consisted of 70 patients who underwent adenosine-mediated stress and rest SPECT. All patients underwent coronary angiography. Semi-quantitative assessment of perfusion was analyzed and produced the summed rest score (SRS), the summed stress score (SSS) and the summed difference score (SDS). The global LV function parameters [ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV)] and regional LV function [the summed motion score (SMS) and the summed thickening score (STS)] were quantified by gated SPECT. Results: Patients were divided into 2 groups: group 1 comprised 16 patients with worsening of LVEF (LVEF_rest-LVEF_ado ≥5%), and group 2 comprised the other 54 patients. Compared with group 2, patients in group 1 had a significantly higher SSS and SDS (9.1 ± 6.8 vs. 5.6 ± 4.5 and 6.6 ± 3.8 vs. 3.6 ± 4.0, respectively; p < 0.05) and the severity of coronary artery stenosis was more serious (p < 0.05). Conclusion: Worsening of LVEF after adenosine-induced vasodilator stress, as shown by ^99mTc-MIBI gated SPECT, is a valuable nonperfusion marker of significant CAD.

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Section: Discussionmentioning

confidence: 99%

Left Ventricular Functional Changes after Adenosine Vasodilator Stress Evaluated by Gated Single-Photon Emission Computed Tomography

Zhang

Tian²,

Zhang³

et al. 2013

Cardiology

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“…To date, the most reliable methods for LVEF assessment are cardiac cine magnetic resonance (MR) imaging [1] and ECG-gated planar or single-photon emission computed tomography (SPECT) equilibrium radionuclide angiocardiography (ERNA) [2,3]. Echocardiography and ECG-gated myocardial perfusion scintigraphy can also be used to assess LVEF with less accuracy [4][5][6][7]. All of these methods have drawbacks [8].…”

Section: Introductionmentioning

confidence: 99%

Innovative procedure for measuring left ventricular ejection fraction from 18F-FDG first-pass ultra-sensitive digital PET/CT images: evaluation with an anthropomorphic heart phantom

et al. 2021

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Background Left ventricular ejection fraction (LVEF) is usually measured by cine-cardiac magnetic resonance imaging (MRI), planar and single-photon emission-computerized tomography (SPECT) equilibrium radionuclide angiocardiography (ERNA), and echocardiography. It would be clinically useful to measure LVEF from first-pass positron-emission tomography/computed tomography (PET/CT) radionuclide angiography, but this approach has been limited by fast radiotracer diffusion. Ultra-sensitive digital PET systems can produce high-quality images within 3-s acquisition times. This study determined whether digital PET/CT accurately measured LVEF in an anthropomorphic heart phantom under conditions mimicking radiotracer first-pass into the cardiac cavities. Methods Heart phantoms in end-diastole and end-systole were 3D-printed from a patient’s MRI dataset. Reference left ventricle end-diastole volume (EDV), end-systole volume (ESV), and LVEF were determined by phantom weights before/after water filling. PET/CT (3-s acquisitions), MRI, and planar and SPECT ERNA were performed. EDV, ESV, and/or LVEF were measured by manual and automated cardiac cavity delineation, using clinical segmentation softwares. LVEF was also measured from PET images converted to 2D “pseudo-planar” images along the short axis and horizontal long axis. LVEF was also calculated for planar ERNA images. All LVEF, ESV and EDV values were compared to the reference values assessed by weighing. Results Manually calculated 3D-PET-CT-based EDV, ESV, and LVEF were close to MRI and reference values. Automated calculations on the 3D-PET-CT dataset were unreliable, suggesting that the SPECT-based tool used for this calculation is not well adapted for PET acquisitions. Manual and automated LVEF estimations from “pseudo-planar” PET images were very close/identical to MRI and reference values. Conclusions First-pass “pseudo-planar” PET may be a promising method for estimating LVEF, easy to use in clinical practice. Processing 3D PET images is also a valid method but to date suffers from a lack of well-suited software for automated LV segmentation.

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Quantification of Ventricular Function

Germano¹,

Berman²

2006

Clinical Gated Cardiac SPECT

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Accuracy of left ventricular ejection fraction determined by gated myocardial perfusion SPECT with Tl-201 and Tc-99m sestamibi: Comparison with first-pass radionuclide angiography

Abstract: LVEF can be accurately assessed by gated SPECT with either Tc-99m sestamibi or Tl-201 in properly selected patients with normal or depressed left ventricular function.

Cited by 50 publications

References 11 publications

Left Ventricular Functional Changes after Adenosine Vasodilator Stress Evaluated by Gated Single-Photon Emission Computed Tomography

Left Ventricular Functional Changes after Adenosine Vasodilator Stress Evaluated by Gated Single-Photon Emission Computed Tomography

Innovative procedure for measuring left ventricular ejection fraction from 18F-FDG first-pass ultra-sensitive digital PET/CT images: evaluation with an anthropomorphic heart phantom

Quantification of Ventricular Function

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