Accuracy of Fine Needle Aspiration Cytology of Salivary Gland Lesions: Routine Diagnostic Experience in Bangkok, Thailand

Nguansangiam, Sudarat; Jesdapatarakul, Somnuek; Dhanarak, Nisarat; Krittika, Sosrisakorn

doi:10.7314/apjcp.2012.13.4.1583

Cited by 37 publications

(13 citation statements)

References 39 publications

(70 reference statements)

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“…In seven studies, all FNAs were performed under ultrasound guidance, while eight studies explicitly mentioned that no radiologic guidance was employed . The use of ancillary studies for the selected cases was reported in 8 studies . ROSE was available in 14 studies …”

Section: Resultsmentioning

confidence: 99%

“…[45][46][47][48][49][50][51][52] The use of ancillary studies for the selected cases was reported in 8 studies. 34,[53][54][55][56][57][58][59] was available in 14 studies. 29,32,37,39,47,51,[59][60][61][62][63][64][65][66] The quality of included studies was assessed according to the QUADAS-2 questionnaire.…”

Section: Selected Studies Characteristics and Quality Assessmentmentioning

confidence: 99%

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Retrospective assessment of the effectiveness of the Milan system for reporting salivary gland cytology: A systematic review and meta‐analysis of published literature

Farahani

Baloch

2018

Diagnostic Cytopathology

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Introduction: Fine needle aspiration (FNA) has been widely utilized in establishing the nature of salivary gland lesions and guiding the clinical management. This study aimed to determine the accuracy of FNA in detecting salivary gland neoplasms and malignancies, employing the "Milan System for Reporting Salivary Gland Cytopathology" (MSRSGC).Method: A systematic search was conducted. The data on FNA and histologic diagnosis were extracted and categorized based on the MSRSGC and risk of malignancy (ROM) was calculated.The risk of publication bias and level of heterogeneity were evaluated. A mixed-effects model was used to estimate FNA accuracy. Meta-regression was conducted to assess the potential effect of different variables on FNA accuracy.Results: Ninety-two studies with a total of 16 456 FNA with surgical follow-up were included.ROM was estimated as 17%, 8%, 34%, 4%, 42%, 58%, and 91%, in nondiagnostic, nonneoplastic, atypia of undetermined significance, benign neoplasm, salivary gland neoplasm of uncertain malignant potential, suspicious for malignancy, and malignant groups, respectively. High level of heterogeneity was detected (P-value <.001). Including cases with definite FNA diagnosis of neoplasm or malignancy, summary estimates of FNA sensitivity, specificity, diagnostic odds ratio, and positive and negative likelihood ratio in detecting neoplasms and malignancies were 96.9%, 95.3%, 636.8, 20.5, and 0.03, and 80.5%, 97.9%, 189.5, 37.8, and 0.2, respectively. Metaregression showed several variables significantly impacting FNA accuracy; however, subgroup analysis did not reduce the level of heterogeneity.Conclusion: FNA can be used as a reliable diagnostic tool in the preoperative evaluation and management of salivary glands lesions. Concise of abstract is using Milan system for reporting salivary gland FNA could increase FNA reliability, facilitate communication, and improve patient care. K E Y W O R D Sdiagnostic accuracy, FNA, meta-analysis, Milan system for reporting salivary gland cytology, salivary gland malignancy, salivary gland neoplasm

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Section: Resultsmentioning

confidence: 99%

Section: Selected Studies Characteristics and Quality Assessmentmentioning

confidence: 99%

Retrospective assessment of the effectiveness of the Milan system for reporting salivary gland cytology: A systematic review and meta‐analysis of published literature

Farahani

Baloch

2018

Diagnostic Cytopathology

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“…Previous studies reported fibroadenoma as the commonest finding in breast lesions followed by breast cancer and fibrocystic disease 12 . Comparison of cytomorphological findings of this study to various literature reports is given in Table 4.…”

Section: Discussionmentioning

confidence: 97%

“…It is minimally invasive, cost-effective, safe, simple, rapid and sensitive as compared to biopsy. 12,13 The main objective of FNAC is to distinguish malignant lesions from benign lesions in order to plan for the treatment protocol and follow-up. 14 In this study, the spectrum of breast lesions on cytomorphological interpretation was benign (33%), inflammatory (21%), suspicious probably benign (2%), suspicious probably malignant (3%), and malignant (41%).…”

Section: Discussionmentioning

confidence: 99%

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Cytomorphological patterns of palpable breast lesions diagnosed on fine needle aspiration cytology in females

et al. 2020

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Breast cancer is the most common malignant tumor and is a leading cause of death worldwide. This study was planned to find out the frequencies of various types of lesions from palpable breasts of female patients through fine needle aspiration cytology. This retrospective study was carried out during December 2017 to May 2018 on 100 female patients presenting with palpable breast mass at University Medical Complex & Research Center, Sargodha, Pakistan. Following written informed consent from patients, a detailed history, patient age, and clinical examination were recorded. The fine needle aspiration cytology was performed and aspirates were processed following the standard methods for cytopathological examination. The cases were grouped according to the five tier reporting format for breast lesion (C1–C5) laid down by the International Academy of Cytologists (IAC) in 2016. The spectrum of breast lesions on cytomorphological interpretation was 54% benign (C2), 2% atypia/suspicious probably benign (C3), 3% suspicious probably malignant (C4) and 41% malignant (C5). Inadequate/insufficient material (C1) was not included in the study. In this study, the specificity, sensitivity, negative and positive predictive value, and diagnostic accuracy of fine needle aspiration cytology were 100%, 91.11%, 98.18%, 100%, and 98.96%, respectively. In benign lesions, maximum cases were of fibroadenoma (24%) followed by fibrocystic disease (4%), lipoma (3%) while benign phyllodes tumor and galactocele were only 1% each. Breast mass was the chief presenting complaint. Breast cancer was commonest among all the morphological patterns of breast lesions followed by fibroadenoma. This study supports that cytological examination using fine needle aspiration cytology is an economical, rapid, easy and valuable diagnostic tool.

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Risk of malignancy associated with cytomorphology subtypes in the salivary gland neoplasm of uncertain malignant potential (SUMP) category in the Milan System: A bi‐institutional study

Chowsilpa

Lose

et al. 2019

Cancer Cytopathology

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BACKGROUND: Salivary gland neoplasm of uncertain malignant potential (SUMP) is a diagnostic category in the Milan System for Reporting Salivary Gland Cytopathology. The objective of this study was to assess the risk of neoplasm (RON) and the risk of malignancy (ROM) in SUMP cases by evaluating them based on their prominent cytomorphology. METHODS:The pathology databases were searched for cases of fine-needle aspiration-diagnosed SUMP at The Johns Hopkins Hospital and Northwestern University from 2013 to 2018. Only cytopathology cases diagnosed as SUMP that had available surgical follow-up were included. RESULTS: Sixty-five patients with SUMP were identified, including 31 men and 34 women who ranged in age from 15 to 87 years (mean age, 55.2 years). Sixty-five cases had histologic follow-up, including 13 (20%) with basaloid features, 13 (20%) with oncocytic features, and 39 (60%) with unspecified features. No cases with clear cell features were found. Overall, the RON in the SUMP category was 95.4% (62 of 65 cases), and the ROM was 33.8% (22 of 65 cases). The RON in SUMPs with basaloid, oncocytic, and unspecified subtypes was 92.3%, 100%, and 94.9%, respectively, whereas the ROM was 38.5%, 7.7%, and 41%, respectively. The most common benign neoplasm was pleomorphic adenoma (23.1%), whereas mucoepidermoid carcinoma (9.2%) was the most common malignant neoplasm. CONCLUSIONS: This study shows that the ROM differs significantly based on cytomorphology subtypes, whereas the overall ROM is approximately the same as the target rate in the Milan System for Reporting Salivary Gland Cytopathology. Moreover, the RON remains high in the SUMP category among different cytomorphology subtypes.Adequate sampling, immunohistochemical staining, and familiarity with metaplastic and reactive changes may improve the diagnosis.

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Accuracy of Fine Needle Aspiration Cytology of Salivary Gland Lesions: Routine Diagnostic Experience in Bangkok, Thailand

Cited by 37 publications

References 39 publications

Retrospective assessment of the effectiveness of the Milan system for reporting salivary gland cytology: A systematic review and meta‐analysis of published literature

Retrospective assessment of the effectiveness of the Milan system for reporting salivary gland cytology: A systematic review and meta‐analysis of published literature

Cytomorphological patterns of palpable breast lesions diagnosed on fine needle aspiration cytology in females

Risk of malignancy associated with cytomorphology subtypes in the salivary gland neoplasm of uncertain malignant potential (SUMP) category in the Milan System: A bi‐institutional study

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