Accuracy of fetal fraction measurements in a single‐nucleotide polymorphism‐based noninvasive prenatal test
Peter Benn,
Jingwen Zhang,
Daniel Lyons
et al.
Abstract:BackgroundNoninvasive prenatal testing (NIPT) for fetal aneuploidy relies on the analysis of fetoplacental cell‐free DNA (cfDNA) found in maternal plasma. A minimum cfDNA fetal fraction (FF) is required for reliable test performance, but some methods may have suboptimal accuracy for FF measurement. This study investigated the accuracy of a single‐nucleotide polymorphism‐ (SNP‐) based NIPT method to assess FF.MethodsFF measurements using SNP‐based NIPT in consecutive samples from singleton male pregnancies were… Show more
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