Accuracy of evaluation and correlation of estimated breeding values among relatives, with evaluation based on information from relatives or from identified loci

Brisbane, J. R.; Gibson, J. Phil

doi:10.1111/j.1439-0388.1995.tb00537.x

Cited by 6 publications

(2 citation statements)

References 15 publications

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“…However a remarkable advantage of MAS is the lower increase of inbreeding with a sex‐limited trait. With BLUP selection, low heritability and a sex‐limited trait, pedigree information plays a determinant role in selecting the best animals, which are likely to be found within the same family, as suggested by B RISBANE and G IBSON (1995). The additional information provided by the bracketed QTL allows selection of animals from different families with consequent reduction of inbreeding.…”

Section: Resultsmentioning

confidence: 99%

Use of marker haplotypes to refine covariances among relatives for breeding value estimation

Pagnacco

Jansen

2001

J Animal Breeding Genetics

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Markers¯anking DNA regions, where quantitative trait loci (QTL) have been previously spotted, can be used to trace the common inheritance of major genes for a better de®nition of covariances among animals. A practical approach to the use of marker data to re®ne the additive relationship matrix used in the traditional best linear unbiased prediction (BLUP) methodology is presented. The technique allows the number of the mixed model equations to be kept to an animal level, blending polygenic pedigree data with marker haplotype information. The advantage of this marker-assisted selection (MAS) approach over BLUP selection has been assessed through a stochastic simulation. A ®nite locus model with 32 independent biallelic loci was generated with normally distributed allelic effects. The heritability of the trait, measured on both sexes and on females only, was set to 0.2 and 0.5. Five-allelic markers 2, 10 and 20 cM apart, bracketed the QTL with the largest effect on the trait, accounting for 17% of the genetic variance. The bracketed QTL had two or eight alleles and its position was unde®ned within the bracket. Results show a moderate 2% advantage of MAS over BLUP in terms of higher genetic response when trait was recorded on both sexes and heritability was 0.2. The bene®t is in the short term, but it lasts longer with polyallelic QTL. When the trait was recorded on females only, MAS produced only a small and insigni®cant genetic gain, but reduced the overall inbreeding in the population. MAS was also inef®cient when heritability was 0.5. ZusammenfassungVerwendung von Marker Haplotypen zur Verbesserung der Kovarianzen zwischen Verwandten in der ZuchtwertschaÈtzung Marker, die DNA-Regionen¯ankieren, in denen Quantitative Trait Loci (QTL) zuvor gefunden wurden, ko È nnen verwendet werden, um die allgemeine Vererbung von Majorgenen zu entschlu È sseln und um Kovarianzen zwischen Tieren besser zu de®nieren. Es wird ein praktikabler Ansatz zur Verwendung von Marker-Daten gezeigt, um die additive Verwandtschaftsmatrix, die in der traditionellen BLUP-Methode benutzt wird, zu verfeinern. Die Technik la Èsst die Zahl der Mixed Model Equations (MME) auf einem Tierlevel und vermischt polygene Pedigreedaten mit Informationen u È ber Markerhaplotypen. Der Vorteil dieses MAS Ansatzes gegenu È ber der BLUP Selektion wurde anhand einer stochastischen Simulation u È berpru È ft. Ein begrenztes Locus-Modell mit 32 unabha Èngigen biallelen Loci wurde mit normalverteilten Alleleffekten erstellt. Die Heritabilita Èt des Merkmals, gemessen sowohl an beiden Geschlechtern als auch nur an den weiblichen Tieren wurde auf 0,2 und 0,5 festgelegt. Marker mit 5 Allelen, die 2, 10 und 20 cM auseinander lagen, teilten den QTL mit dem gro È ûten Effekt auf das Merkmal, unter Beru È cksichtigung von 17% der genetischen Varianz. Der zerlegte QTL hatte zwei oder acht Allele und seine Position war innerhalb der Abschnitte nicht de®niert. Die Ergebnisse zeigen einen moderaten 2-%igen Vorteil der MAS gegenu È ber BLUP in Bezug auf eine ho È here genetisc...

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Section: Resultsmentioning

confidence: 99%

Use of marker haplotypes to refine covariances among relatives for breeding value estimation

Pagnacco

Jansen

2001

J Animal Breeding Genetics

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“…If the population is also undergoing selection on either phenotypes or estimated breeding values (EBV), then the rate of inbreeding increases as shown by BELONSKY and KENNEDY (1988). The rate of inbreeding can be controlled by various methods while maximizing genetic response as demonstrated by QUINTON and SMITH (1995), WRAY andGODDARD (1994), andBRISBANE andGIBSON (1995).…”

Section: Introductionmentioning

confidence: 99%

Including coefficients of inbreeding in BLUP evaluation and its effect on response to selection

Mehrabani-Yeganeh

Gibson

Schaeffer

2000

J Animal Breeding Genetics

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Stochastic simulation was used to study the effect on selection response of accounting for inbreeding versus ignoring it in the construction of the inverse of the relationship matrix used in mixed model equations (MME) to obtain BLUP of breeding values. Three different heritabilities of 0.10, 0.25, and 0.50 and two different family structures were used. Selection of replacement animals was based on best linear unbiased predictors (BLUP) of breeding values using an animal model. Average inbreeding coefficients (F) were in the range of 0.4-0.5 after 11 generations of selection. Even with such high inbreeding levels, no significant differences in selection responses were found between accounting or ignoring F in MME construction over the range of heritabilities and family structures.

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Including genetic relationships in selection decisions: alternative methodologies

Brisbane

Gibson

1995

Theoret. Appl. Genetics

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Investigations are made of variations in an iterative methodology previously introduced for reducing inbreeding by including genetic relationships in selection decisions, using adjusted estimated breeding values (EBV). An alternative computing strategy for maximising the value of the population selection criterion is shown to involve less computation, which results in function values as great or greater than the original method. Alteration of weights for different types of relationships in the adjusted EBV has no detectable effect on genetic gain at a given level of inbreeding. Selection using the adjusted EBV method in one sex and truncation on EBV in the other sex results in less genetic gain at a given level of inbreeding than using adjusted EBV in both sexes, but results in more gain at a given level of inbreeding than three selection strategies that do not include genetic relationships in selection decisions. The advantage of the adjusted EBV method over these three methods is retained when selection is for a sexlimited trait.

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Accuracy of evaluation and correlation of estimated breeding values among relatives, with evaluation based on information from relatives or from identified loci

Cited by 6 publications

References 15 publications

Use of marker haplotypes to refine covariances among relatives for breeding value estimation

Use of marker haplotypes to refine covariances among relatives for breeding value estimation

Including coefficients of inbreeding in BLUP evaluation and its effect on response to selection

Including genetic relationships in selection decisions: alternative methodologies

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