In most cases, exercise is beneficial for cardiovascular disease, but sometimes exercise can trigger sudden death, and different factors influence the common causes of premature death. Although most cases of sudden death have a rapid onset, some of these deaths can be predicted in advance. For example, cardiovascular screening is clinically significant for preventing sudden cardiac death. There are many types of early screening, the most common being electrocardiography (ECG), ambulatory blood pressure, coronary angiography, computerized tomography (CT), PET-CT, and ECG general exercise testing. Some national and regional clubs have made cardiovascular screening a mandatory pre-competition test for athletes to reduce the likelihood of sudden death during competition. However, to date, cardiovascular screening has not been widely available in the general population worldwide, taking into account numerous factors. This article will discuss why cardiovascular screening is unsuitable for use in the general population in terms of low prevalence, differences in screening modalities corresponding to different pathogenesis, and the inaccuracy and high cost of differential cardiac screening methods.