Accuracy of Corneal Thickness by Swept-Source Optical Coherence Tomography and Scheimpflug Camera in Virgin and Treated Fuchs Endothelial Dystrophy

Arnalich‐Montiel, Francisco; Ortiz-Toquero, Sara; Auladell, Clara; Couceiro, Ana

doi:10.1097/ico.0000000000001530

Cited by 11 publications

(13 citation statements)

References 23 publications

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“…Regarding diagnostic devices, the slitlamp microscope alone was the most frequently used diagnostic device in 31 of 61 articles (51%), 6,13–42 whereas 11 articles (18%) used a slitlamp microscope in combination with other devices/methods, such as in vivo confocal microscope (IVCM), 43–47 specular microscope, 48–51 pachymetry, 49,50 AS-OCT, 46 interview, 52 and histological diagnosis (Table 2). 53 Overall, slitlamp examination was used in 45 of 61 articles (74%).…”

Section: Resultsmentioning

confidence: 99%

Systematic Review of the Diagnostic Criteria and Severity Classification for Fuchs Endothelial Corneal Dystrophy

Oie,

Yamaguchi,

Nishida

et al. 2023

Cornea

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Purpose: There are no defined diagnostic criteria and severity classification for Fuchs endothelial corneal dystrophy (FECD), which are required for objective standardized assessments. Therefore, we performed a systematic literature review of the current diagnosis and severity classification of FECD. Methods: We searched the Ovid MEDLINE and Web of Science databases for studies published until January 13, 2021. We excluded review articles, conference abstracts, editorials, case reports with <5 patients, and letters. Results: Among 468 articles identified, we excluded 173 and 165 articles in the first and second screenings, respectively. Among the 130 included articles, 61 (47%) and 99 (76%) mentioned the diagnostic criteria for FECD and described its severity classification, respectively. Regarding diagnosis, slitlamp microscope alone was the most frequently used device in 31 (51%) of 61 articles. Regarding diagnostic findings, corneal guttae alone was the most common parameter [adopted in 23 articles (38%)]. Regarding severity classification, slitlamp microscopes were used in 88 articles (89%). The original or modified Krachmer grading scale was used in 77 articles (78%), followed by Adami's classification in six (6%). Specular microscopes or Scheimpflug tomography were used in four articles (4%) and anterior segment optical coherence tomography in one (1%). Conclusions: FECD is globally diagnosed by the corneal guttae using slitlamp examination, and its severity is predominantly determined by the original or modified Krachmer grading scale. Objective severity grading using Scheimpflug or anterior segment optical coherence tomography can be applied in the future innovative therapies such as cell injection therapy or novel small molecules.

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Section: Resultsmentioning

confidence: 99%

Systematic Review of the Diagnostic Criteria and Severity Classification for Fuchs Endothelial Corneal Dystrophy

Oie,

Yamaguchi,

Nishida

et al. 2023

Cornea

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“…Arnalich-Montiel et al demonstrated that AS-OCT is superior to the Scheimpflug imaging system in visualizing deep corneal tissue, even in eyes with corneal opacity. 14 As an objective grading in FECD, anterior corneal backscatter of Scheimpflug images is reportedly higher in FECD. [15][16][17][18][19] Alnawaiseh et al 18 evaluated corneal light backscatter (densitometry) of the posterior cornea (60 mm from DM including the posterior stroma) and found that corneal light backscatter was greater in FECD than in normal controls and decreased after DSAEK or DMEK.…”

Section: Discussionmentioning

confidence: 97%

Three-Dimensional Assessment of Descemet Membrane Reflectivity by Optical Coherence Tomography in Fuchs Endothelial Corneal Dystrophy

Suzuki

Yamaguchi

Yagi-Yaguchi

et al. 2023

Cornea

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Purpose: This study aimed to evaluate Descemet membrane reflectivity using anterior segment optical coherence tomography (AS-OCT) in eyes with Fuchs endothelial corneal dystrophy (FECD). Methods: We retrospectively assessed 144 eyes of 88 consecutive participants (41 FECD, 15 pseudophakic bullous keratopathies [BKs], and 32 healthy controls, 63.5 ± 16.5 years). FECD was graded 0 to 3 based on the guttae areas using specular microscopy. The sum of AS-OCT reflectivity of the 3-dimensional volume from 10 μm thickness from the endothelial surface of the cornea and residual stromal area was calculated as Dsum(endo) and Dsum(stroma) in the central area of 3- and 6-mm diameters, respectively. The DES ratio was defined as the ratio of Dsum(endo) to Dsum(stroma). The percentage of the guttae area in the specular images was calculated using MATLAB. Dsum(endo) and DES ratio were compared among FECD, BK, and healthy controls. Results: Dsum(endo) in FECD grade 3 was significantly higher than that in healthy control eyes, FECD patients with mild and moderate guttae, and BK (all P ≤ 0.040). The DES ratio in FECD patients with mild to severe guttae (grade 1–3) was significantly higher than that in healthy control eyes and BK (all P ≤ 0.035). The percentage of the guttae area was significantly correlated with Dsum(endo) (R = 0.488, P < 0.001 for 3 mm, R = 0.512, P < 0.001 for 6 mm) and DES ratio (R = 0.450, P < 0.001 for 3 mm, R = 0.588, P < 0.001 for 6 mm). Conclusions: Descemet membrane reflectivity in AS-OCT can be objective biomarkers for assessing guttae and FECD severity from early to end-stage FECD.

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“…We opted to use anterior segment OCT rather than Scheimpflug imaging, as the former is considered to deliver more accurate and reliable measurements of corneal volume (Arnalich‐Montiel et al. ). Previous reports indicate that corneal thinning results from long‐standing, severe inflammation (Meisler et al.…”

Section: Discussionmentioning

confidence: 99%

Meibography and corneal volume optical coherence tomography to quantify damage to ocular structures in children with blepharokeratoconjunctivitis

Al-Hayouti

Daniel

Hingorani

et al. 2019

Acta Ophthalmologica

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Purpose To evaluate non‐contact infrared meibography and anterior segment optical coherence tomography (AS‐OCT) to detect meibomian gland (MG) and corneal changes in children with blepharokeratoconjunctivitis (BKC). Methods We acquired infrared meibography images of upper and lower lids and AS‐OCT corneal scans. One masked observer graded meiboscore, full/partial MG dropout, and measured total corneal volume and differential corneal volume per quadrant and central corneal thickness (CCT). Results We enrolled 63 children, 31 with BKC and 32 without ocular surface inflammation; median (interquartile range) age BKC 10.6 (7.2‐13.9) years, healthy volunteers (HV) 11.4 (9.5‐13.8) years. Likert scale scores for meibography and OCT indicate no to low discomfort. Meiboscores for upper and lower lids as well as the total meiboscore were significantly higher in children with BKC than in HV. Subscores for full and partial MG dropout were also significantly higher in children with BKC than in healthy volunteers. There was no statistically significant difference between upper and lower lid for meiboscore nor full/partial MG dropout scores. The corneal volume in the superior quadrant was significantly higher in children with BKC than in HV, whereas the corneal volume in the nasal and inferior quadrants was significantly lower. Conclusions Non‐contact imaging technologies objectively demonstrate damage to meibomian glands and changes in corneal volume secondary to BKC. The tests are well tolerated by children with mild/moderate ocular surface inflammation and can detect changes without the requirement for routine eversion of the upper lid. These parameters may be useful both for clinical follow‐up and clinical trials.

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Accuracy of Corneal Thickness by Swept-Source Optical Coherence Tomography and Scheimpflug Camera in Virgin and Treated Fuchs Endothelial Dystrophy

Cited by 11 publications

References 23 publications

Systematic Review of the Diagnostic Criteria and Severity Classification for Fuchs Endothelial Corneal Dystrophy

Systematic Review of the Diagnostic Criteria and Severity Classification for Fuchs Endothelial Corneal Dystrophy

Three-Dimensional Assessment of Descemet Membrane Reflectivity by Optical Coherence Tomography in Fuchs Endothelial Corneal Dystrophy

Meibography and corneal volume optical coherence tomography to quantify damage to ocular structures in children with blepharokeratoconjunctivitis

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