Accuracy of core needle biopsy for the diagnosis of osteosarcoma: A retrospective analysis of 73patients

Taupin, T.; Decouvelaere, Anne‐Valérie; Vaz, Gualter; Thiesse, Philippe

doi:10.1016/j.diii.2015.09.013

Cited by 20 publications

(11 citation statements)

References 24 publications

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“…Osteosarcoma is the malignant bone tumor associated with WS [26]. Osteosarcomas in WS patients are more commonly developed in the lower extremities, whereas they predominantly affect the upper extremities in the general population [8,26,27]. It is thus important to diagnose WS at an early stage, and to further investigate patients with clinical signs that may suggest bone or soft-tissue sarcoma.…”

Section: Neoplasiamentioning

confidence: 99%

Radiographic presentation of musculoskeletal involvement in Werner syndrome (adult progeria)

David

Vincent

Arrigoni

et al. 2017

Diagnostic and Interventional Imaging

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Werner syndrome (i.e., adult progeria) is a rare autosomal recessive disorder caused by mutations of the WRN gene, which is characterized by the premature appearance of features associated with normal aging and cancer predisposition. Patients with Werner syndrome can present with musculoskeletal complaints, associated with suggestive radiographic features with a potential prognostic or therapeutic impact. This review illustrates the main radiographic features of Werner syndrome, focusing on the musculoskeletal system, such as soft-tissue calcification, muscular atrophy, osteoporosis, foot deformities, osteitis and osteomyelitis, and bone or soft-tissues malignancies. The identification of these features by radiologists can therefore be useful in the clinical screening of Werner syndrome.

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Section: Neoplasiamentioning

confidence: 99%

Radiographic presentation of musculoskeletal involvement in Werner syndrome (adult progeria)

David

Vincent

Arrigoni

et al. 2017

Diagnostic and Interventional Imaging

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“…And new imaging modality for prebiopsy evaluation and/or guidance during biopsy may lead to more precise location of viable tissues, therefore improving diagnostic yield and accuracy. PET-CT 28,29 , MRI 25,30 and contrast ultrasound 31 have shown promising utility. Moreover, augmented reality-assisted biopsy technique may facilitate more accurate passages towards targeted tissue 32 .…”

Section: Discussionmentioning

confidence: 99%

Reliability of Ultrasound-Guided Percutaneous Core Needle Biopsy in Diagnostics of Pediatric Solid Tumors

Chen

Huang

Feng

et al. 2020

Preprint

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Background: Ultrasound-guided percutaneous core needle biopsy (PCNB) has been used more and more frequently in diagnostics of pediatric solid tumors in our center. It is less invasive than an incisional biopsy. However, reports relating to its reliability in clinical practice are limited. Therefore, we aim to investigate the reliability of this technique in the pediatric population. Methods: A 7-year retrospective study including patients [?] 18 years who underwent ultrasound-guided PCNB in our center was conducted. Children who received PCNB and final surgical treatment were included. Their medical records were reviewed. Final surgical pathological diagnoses were used as the gold standard to assess the diagnostic efficiency of PCNB. Results: A total of 169 children were included in our analysis. 87.0% of patients underwent PCNB for abdominal and pelvic masses. 79.1% of biopsies were performed under local anesthesia. There were 141 malignancies and 28 benign lesions confirmed by surgery. The most common malignancy was neuroblastoma (73), and the most common benign condition was fibromatosis. The diagnostic yield was 94.1%. The success rate of PCNB in determining benign and malignant conditions was 94.3% (150/159). Consistency between PCNB and final diagnoses was found in 143 cases, giving a total accuracy of 89.9%. The accuracy for diagnosing malignancies was 96.8% (122/126), and for benign diseases 87.5% (21/24). The difference was not statistically significant (p=0.0818). Severe complications occurred in 6 patients (3.5%). No evidence of needle tract dissemination was found. Conclusions: Ultrasound-guided PCNB is safe and effective in diagnosing pediatric solid tumors, especially in malignancies. Background: Ultrasound-guided percutaneous core needle biopsy (PCNB) has been used more and more frequently in diagnostics of pediatric solid tumors in our center. It is less invasive than an incisional biopsy. However, reports relating to its reliability in clinical practice are limited. Therefore, we aim to investigate the reliability of this technique in the pediatric population. Methods: A 7-year retrospective study including patients [?] 18 years who underwent ultrasound-guided PCNB in our center was conducted. Children who received PCNB and final surgical treatment were included. Their medical records were reviewed. Final surgical pathological diagnoses were used as the gold standard to assess the diagnostic efficiency of PCNB. Results: A total of 169 children were included in our analysis. 87.0% of patients underwent PCNB for abdominal and pelvic masses. 79.1% of biopsies were performed under local anesthesia. There were 141 malignancies and 28 benign lesions confirmed by surgery. The most common malignancy was neuroblastoma (73), and the most

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“…The new method which used to diagnose osteosarcoma aims at detecting biomarkers including microRNAs, long non-coding RNAs, circulating tumor cells, and circulating tumor DNA. There are a lot of advantages in the new method, called liquid biopsy, when compared to conventional methods, such as, low sample volume, greater accuracy, less expensive, and easy detection [1,15].…”

Section: Diagnosis and Possible Target Therapies For Osteosarcomamentioning

confidence: 99%

Velvet Antler compounds targeting major cell signaling pathways in osteosarcoma - a new insight into mediating the process of invasion and metastasis in OS

Zhang

et al. 2019

Open Chemistry

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Velvet antler is the only renewable bone tissue of mammalian animals, which consists of a variety of growth factors, amino acids and polypeptides. But the mechanism of high-speed proliferation without carcinogenesis is still mystifying. The previous study of this work found that the velvet antler peptides (VAP) could not only inhibit the proliferation and migration of osteosarcoma cell lines MG-63 and U2OS, but also induced U2OS apoptosis and inhibited MG-63 epithelial-mesenchymal transition (EMT) through TGF-β and Notch pathways. These results lead us to conclude that VAP has the potential ability to mediate osteosarcoma cells by regulating related signaling pathways and growth factors. Therefore, finding a new appropriate inhibitor for OS is a valuable research direction, which will give patients a better chance to receive proper therapy. From an applied perspective, this review summarized the effects of velvet antler, genes, growth factors and research progress of relative pathways and genes of osteosarcoma, which are poised to help link regenerative molecular biology and regenerative medicine in osteosarcoma pathogenesis.

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Accuracy of core needle biopsy for the diagnosis of osteosarcoma: A retrospective analysis of 73patients

Abstract: IV.

Cited by 20 publications

References 24 publications

Radiographic presentation of musculoskeletal involvement in Werner syndrome (adult progeria)

Radiographic presentation of musculoskeletal involvement in Werner syndrome (adult progeria)

Reliability of Ultrasound-Guided Percutaneous Core Needle Biopsy in Diagnostics of Pediatric Solid Tumors

Velvet Antler compounds targeting major cell signaling pathways in osteosarcoma - a new insight into mediating the process of invasion and metastasis in OS

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