Accuracy of cone-beam computed tomography, digital mammography and digital breast tomosynthesis for microcalcifications and margins to microcalcifications in breast specimens

Neubauer, Claudia; Yilmaz, Jannina Samantha; Bronsert, Peter; Pichotka, M.; Bamberg, Fabian; Windfuhr-Blum, M; Erbes, Thalia; Neubauer, Jakob

doi:10.1038/s41598-022-21616-3

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…Lately, there has been an increased research interest [3] and clinical evaluation of conebeam CT systems, dedicated to breast imaging. Cone-beam CT avoids tissue overlapping and provides a more sensitive evaluation for dense breasts (mean density d = 1.1 g/cm 3 [43]).…”

Section: Discussionmentioning

confidence: 99%

“…The bone sphere is hard to distinguish, mainly in FBP-reconstructed images. Furthermore, compared to the three other materials, it has the lowest density of 1.4 g/cm 3 (GATE data [28]) (d Al = 2.7 g/cm 3 , d PVC = 1.65 g/cm 3 , d glass = 2.5 g/cm 3 ). This is also shown by the CNR ratios, which for the bone "source", can be above the Rose criterion.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, it presents images with high sensitivity and specificity that lessen the possibility of a false diagnosis or even reduce the need for a breast biopsy [1]. Additionally, quantitative material decomposition, including the quantification of contrast agents, electron density, and virtual monoenergetic images, is also applicable to CBCT [3,4].…”

Section: Introductionmentioning

confidence: 99%

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Novel Detector Configurations in Cone-Beam CT Systems: A Simulation Study

Karali,

Michail,

Fountos

et al. 2024

Crystals

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Cone-beam computed tomography (CBCT) has emerged in recent years as an adequate alternative to mammography and tomosynthesis due to the several advantages over traditional mammography, including its ability to provide 3D images, its reduced radiation dose, and its ability to image dense breasts more effectively and conduct more effective breast compressions, etc. Furthermore, CBCT is capable of providing images with high sensitivity and specificity, allowing a more accurate evaluation, even of dense breasts, where mammography and tomosynthesis may lead to a false diagnosis. Clinical and experimental CBCT systems rely on cesium iodine (CsI:Tl) scintillators for X-ray energy conversion. This study comprises an investigation among different novel CBCT detector technologies, consisting either of scintillators (BGO, LSO:Ce, LYSO:Ce, LuAG:Ce, CaF2:Eu, LaBr3:Ce) or semiconductors (Silicon, CZT) in order to define the optimum detector design for a future experimental setup, dedicated to breast imaging. For this purpose, a micro-CBCT system was adapted, using GATE v9.2.1, consisting of the aforementioned various detection schemes. Two phantom configurations were selected: (a) an aluminum capillary positioned at the center of the field of view in order to calculate the system’s spatial resolution and (b) a breast phantom consisting of spheres of different materials, such that their characteristics are close to the breast composition. Breast phantom contrast-to-noise ratios (CNRs) were extracted from the phantom’s tomographic images. The images were reconstructed with filtered back projection (FBP) and ordered subsets expectation-maximization (OSEM) algorithms. The semiconductors acted satisfactorily in low-density matter, while LYSO:Ce, LaBr3:Ce, and LuAG:Ce presented adequate CNRs for all the different spheres’ densities. The energy converters that are presented in this study were evaluated for their performance against the standard CsI:Tl crystal.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Novel Detector Configurations in Cone-Beam CT Systems: A Simulation Study

Karali,

Michail,

Fountos

et al. 2024

Crystals

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Emerging Clinical Applications for Cone Beam Breast CT: Changing the Breast Imaging Paradigm

Siddall,

Zhang,

O’Connell

2024

Curr Breast Cancer Rep

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Purpose of Review Since its approval by the Unites States Food and Drug Administration (FDA) in 2015, cone-beam breast computed tomography (CBBCT) has gained acceptance among radiologists for breast cancer imaging. This review aims to highlight the advancements and benefits of CBBCT in the diagnostic workup of breast disease. It showcases how CBBCT, including both non-contrast (NC-CBBCT) and contrast-enhanced (CE-CBBCT) protocols, complements and often surpasses the performance of more traditional breast imaging modalities such as mammography and magnetic resonance imaging (MRI). Recent Findings Studies in clinical settings have shown CBBCT’s efficacy in detecting and characterizing breast lesions of differing morphologies, including non-mass enhancement and calcifications—tasks that previously required the use of multiple modalities. In addition, CBBCT significantly enhances patient comfort and efficiency, offering quick acquisition times without the discomfort of breast compression. The technology can be utilized for guiding biopsies, planning surgical interventions, and assessing breast density and tumor characteristics, evidence supporting its integration into clinical practice. Summary CBBCT holds the potential to shift the imaging paradigm in breast cancer care, indicating a promising future for the modality in terms of enhancing diagnostic accuracy, improving patient experience, and influencing treatment outcomes.

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Reference Range of CT Value in NC-CBBCT Based on Female Breast Structure

Wei

Zhong

Kang

et al. 2023

CMIR

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aims: To determine the reference range of CT values in Cone-beam breast computed tomography. background: As a new high-resolution three-dimensional CT imaging technology, the essential reference range of CT values in Cone-beam breast computed tomography (CBBCT) has not been established to date. objective: To determine the reference range of computed tomography (CT) values in CBBCT for breast clinical examination. method: In total, 913 cases (1167 lateral) were subject to CBBCT. CT values of the gland, fat and different quadrants and different distances of CBBCT images were analyzed. The nipple and muscle were also evaluated. result: A total of 672 lateral breasts were included in the normal group for investigation. The reference range of the absolute CT value of chest wall muscle is -136.68~43.36 HU. The reference range of the absolute CT value of nipple is 176.39~334.02 HU. The reference range of the absolute CT value of fat is -190.4~-63.67HU, and of gland is -12.2~51.83HU. conclusion: Our results firstly established the baseline CT values of Non-contrast CBBCT in female breasts, which will benefit for cancer screening and lesion locating. The closer the normal breast fat and gland is to the nipple, the greater the CT value. The older the age, the lower the density. The CT values of fat are unstable in the distance less than 5 cm, and the CT values of glands are relatively stable. The difference between the upper and lower quadrants is significant in the same lateral breast and the same section. other: CT values can be directly used in clinical differential diagnosis of breast lesions.

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Accuracy of cone-beam computed tomography, digital mammography and digital breast tomosynthesis for microcalcifications and margins to microcalcifications in breast specimens

Cited by 4 publications

References 34 publications

Novel Detector Configurations in Cone-Beam CT Systems: A Simulation Study

Novel Detector Configurations in Cone-Beam CT Systems: A Simulation Study

Emerging Clinical Applications for Cone Beam Breast CT: Changing the Breast Imaging Paradigm

Reference Range of CT Value in NC-CBBCT Based on Female Breast Structure

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