Accuracy of cancer diagnostic probe for intra‐surgical checking of cavity side margins in neoadjuvant breast cancer cases: A human model study

Abstract

Background: Background Recently, a real-time system, named cancer diagnostic probe (CDP), has been developed to diagnose the presence of pre-neoplastic/ neoplastic cells in breast cavity side margins. Detecting mechanism is real-time determination of the ROS/H 2 O 2 released from cancer or atypical cells, through reverse Warburg effect and hypoxia glycolysis pathways.Aims: Here, we designed a human model study based on real-time checking of 387 internal margins (IM) from 39 neoadjuvant breast cancer cases by CDP.Materials & Methods: Each lesion was checked by entered needle sensor and electrical scores were recorded. The permanent pathology result of each tested lesion was our gold standard to evaluate CDP scoring. CDP results were compared with permanent pathology of tumour side margins (as a conventional margin evaluation procedure).Results: Results showed that the sensitivity of CDP in scoring the cavity side margins of those cases is 91%. A total of 18 involved IM which had been detected by CDP were declared as free margins in pathology section of tumour side samples.Just five involved IM were missed by CDP.

Human study on cancer diagnostic probe (CDP) for real‐time excising of breast positive cavity side margins based on tracing hypoxia glycolysis; checking diagnostic accuracy in non‐neoadjuvant cases

“…However, direct checking of cavity side margins after tumor excision may prevent tumor bed from remaining cancer residues and lead to decreased risk of reoperation and/or healthcare costs. Aside from the limitations of frozen techniques, evaluating just tumor side borders may not be sufficient to be ensured from clearance of cavity side interface, 27 Hence, a lot of effort has been put into developing new techniques for the direct evaluation of cavity side margins. Cancer diagnostic probe (CDP) showed this ability as a handheld real‐time diagnostic tool with pathological classification.…”

“…This can be used as a great complementary system near or maybe as an alternative procedure instead of a frozen section. Tumor side evaluation (even with slide preparation from the whole surface of the margin) might not provide reassurance about clearance of cavity side margins 27 . Hence, CDP may shed new light in the future as an intra‐operative cavity side margin evaluating system.…”

“…Tumor side evaluation (even with slide preparation from the whole surface of the margin) might not provide reassurance about clearance of cavity side margins. 27 Hence, CDP may shed new light in the future as an intra‐operative cavity side margin evaluating system. Here, we applied CDP in multi‐clinical studies to compare its efficacy with the frozen section.…”