Accuracy of and reasons for frozen sections: A correlative, retrospective study

Sawady, Joram; Berner, Jerome J.; Siegler, Edward E.

doi:10.1016/s0046-8177(88)80080-7

Cited by 52 publications

(30 citation statements)

References 12 publications

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“…Comparisons of accuracy and TAT for frozen sections between centers must consider differences in the types of frozen sections performed in each center [34]. Most of our TP frozen sections are biopsy specimens submitted by neurosurgeons to establish a diagnosis of an unknown pathologic process.…”

Section: Comparisons With Other Tp Frozen Section Programsmentioning

confidence: 99%

Primary frozen section diagnosis by robotic microscopy and virtual slide telepathology: the University Health Network experience

Evans¹,

Chetty²,

Clarke³

et al. 2009

Human Pathology

138

112

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Section: Comparisons With Other Tp Frozen Section Programsmentioning

confidence: 99%

Primary frozen section diagnosis by robotic microscopy and virtual slide telepathology: the University Health Network experience

Evans¹,

Chetty²,

Clarke³

et al. 2009

Human Pathology

138

112

View full text Add to dashboard Cite

“…[16][17][18][19][20] Currently a 5 mm margin is recommended for MIS when treated by routine excision without frozen margin control. Some have demonstrated the accuracy of diagnosing melanoma using standard frozen sections stained with hematoxylin and eosin (H&E), [41][42][43][44][45][46][47] while others have questioned their reliability for margin evaluation. 26,[28][29][30]34 Among experienced pathologists and surgeons, controversy exists regarding the best way to visualize the tumor histologically, a fundamental precept of the Mohs technique.…”

mentioning

confidence: 99%

Mohs Micrographic Surgery for Melanoma: A Case Series, a Comparative Study of Immunostains, an Informative Case Report, and a Unique Mapping Technique

et al. 2002

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MM, especially MIS on the head and neck, often exhibits an asymmetric growth pattern, making it quite suitable for treatment with MMS. The use of MART-1 immunostain may improve the diagnostic accuracy of Mohs surgeons. We believe that HMB-45 should not be used to rule out the diagnosis of MIS in equivocal sections because of its inferior sensitivity. We introduce a new mapping technique as an adjunctive measure to aid in the clinicopathologic evaluation of perilesional skin.

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“…The studies on general surgical cases and otolaryngologic cases show similar findings with a 95 to 98% diagnostic accuracy rate, a 2 to 4% error rate (including less than 2% false negative and less than 1% false positive) and less than 4% of cases being deferred for permanent section evaluation [1][2][3][4][5][6][7][8][9][10][11][12]. Diagnostic errors may occur due to improper sampling, technical flaws, interpretive inaccuracies and in faulty communication.…”

Section: Surgeon's Expectations Of the Intraoperative Assessment Of Mmentioning

confidence: 77%

Intraoperative Consultation (IOC) in Mucosal Lesions of the Upper Aerodigestive Tract

Wenig

2008

Head and Neck Pathol

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Intraoperative consultation (frozen section) plays an important part in the treatment of the head and neck cancer patient. The appropriate use of intraoperative consultations (frozen sections) usually results in a definitive diagnosis with immediate therapeutic impact while the patient is in the operating room. Among the determinations made by frozen section analysis include the evaluation of adequacy of surgical margins of resection; the differentiation between nonneoplastic, benign and malignant proliferations; the evaluation of lymph nodes for the presence of metastatic disease; the determination of specimen identification and specimen adequacy, including the verification of such organs as the parathyroid glands; and the determination of whether a given case requires special diagnostic testing best performed on frozen material, such as for lymphomas. This paper focuses on intraoperative consultation of mucosal lesions of the upper aerodigestive tract, including epithelial dysplasia and squamous cell carcinoma. Other issues that often not diagnosed or at issue at the time of surgery, including the diagnosis of microinvasive carcinoma and differentiating inflammatory lesions from neoplastic lesions are included for completion.

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Accuracy of and reasons for frozen sections: A correlative, retrospective study

Cited by 52 publications

References 12 publications

Primary frozen section diagnosis by robotic microscopy and virtual slide telepathology: the University Health Network experience

Primary frozen section diagnosis by robotic microscopy and virtual slide telepathology: the University Health Network experience

Mohs Micrographic Surgery for Melanoma: A Case Series, a Comparative Study of Immunostains, an Informative Case Report, and a Unique Mapping Technique

Intraoperative Consultation (IOC) in Mucosal Lesions of the Upper Aerodigestive Tract

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