Accuracy of Alcohol Use Disorders Identification Test for Detecting Problem Drinking in 18–35 Year-Olds in England: Method Comparison Study

Foxcroft, David; Smith, L. A.; Thomas, Hayley; Howcutt, Sarah J.

doi:10.1093/alcalc/agu095

Cited by 36 publications

(26 citation statements)

References 20 publications

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“…Subjects in the CTR group were excluded after screening for alcohol dependence or alcohol abuse, but no information regarding number of drinks or AUDIT score was collected. However, several studies indicate that AUDIT and DSM-IV have similar specificity (Dawson et al, 2012; Foxcroft et al, 2015) providing evidence that subjects in the CTR group were likely assigned to the correct group. A second limitation of the current study is the lack of inclusion of other measures that could have been useful to distinguish among the four sample groups.…”

Section: Discussionmentioning

confidence: 99%

Alterations of resting state functional network connectivity in the brain of nicotine and alcohol users

et al. 2017

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Alcohol and nicotine intake result in neurological alterations at the circuit level. Resting state functional connectivity has shown great potential in identifying these alterations. However, current studies focus on specific seeds and leave out many brain regions where effects might exist. The present study uses a data driven technique for brain segmentation covering the whole brain. Functional magnetic-resonance-imaging (fMRI) data were collected from 188 subjects: 51 non-substance consumption controls (CTR), 36 smoking-and-drinking subjects (SAD), 28 drinkers (DRN), and 73 smokers (SMK). Data were processed using group independent component analysis to derive resting state networks (RSN). The resting state functional network connectivity (rsFNC) was then calculated through correlation between time courses. One-way ANOVA tests were used to detect rsFNC differences among the four groups. A total of 50 ANOVA tests were significant after multi-comparison correction. Results delineate a general pattern of hypo-connectivity in the substance consumers. Precuneus, postcentral gyrus, insula and visual cortex were the main brain areas with rsFNC reduction suggesting reduced interoceptive awareness in drinkers. In addition, connectivity reduction between postcentral and one RSN covering right fusiform and lingual gyri showed significant association with severity of hazardous drinking. In smokers, connectivity changes agreed with the idea of a shift towards endogenous information processing, represented by the DMN. Hypo-connectivity between thalamus and putamen was observed in smokers. In contrast, the angular gyrus showed hyper-connectivity with the precuneus linked to smoking and significantly correlated with nicotine dependence severity. In spite of the presence of common effects, our results suggest that particular effects of alcohol and nicotine can be separated and identified. Results also suggest that concurrent use of both substances affects brain connectivity in a complex manner, requiring careful consideration of interaction effects.

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Section: Discussionmentioning

confidence: 99%

Alterations of resting state functional network connectivity in the brain of nicotine and alcohol users

et al. 2017

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“…The AUROC results in our study suggested that the AUDIT-KR was an appropriate diagnostic tool for screening for AUD according to DSM-5 criteria. A previous article from the United Kingdom reported that the AUDIT was useful for AUD screening in both genders, ranging in age from 18 to 35 years according to DSM-5 criteria (males: AUROC, 0.70; 95% CI, 0.60 to 0.78; females: AUROC, 0.73; 95% CI, 0.67 to 0.78) 15). The AUROC results in that article were lower than the results found by our study.…”

Section: Discussionmentioning

confidence: 99%

Validity of Alcohol Use Disorder Identification Test-Korean Revised Version for Screening Alcohol Use Disorder according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition Criteria

et al. 2016

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BackgroundThe Alcohol Use Disorder Identification Test (AUDIT) has been widely used to identify alcohol use disorder (AUD). This study evaluated the validity of the AUDIT-Korean revised version (AUDIT-KR) for screening AUD according to Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) criteria.MethodsThis research was conducted with 443 subjects who visited the Chungnam National University Hospital for a comprehensive medical examination. All subjects completed the demographic questionnaire and AUDIT-KR without assistance. Subjects were divided into two groups according to DSM-5 criteria: an AUD group, which included patients that fit the criteria for AUD (120 males and 21 females), and a non-AUD group, which included 146 males and 156 females that did not meet AUD criteria. The appropriate cut-off values, sensitivity, specificity, and positive and negative predictive values of the AUDIT-KR were evaluated.ResultsThe mean±standard deviation AUDIT-KR scores were 10.32±7.48 points in males and 3.23±4.42 points in females. The area under the receiver operating characteristic curve (95% confidence interval, CI) of the AUDIT-KR for identifying AUD was 0.884 (0.840–0.920) in males and 0.962 (0.923–0.985) in females. The optimal cut-off value of the AUDIT-KR was 10 points for males (sensitivity, 81.90%; specificity, 81.33%; positive predictive value, 77.2%; negative predictive value, 85.3%) and 5 points for females (sensitivity, 100.00%; specificity, 88.54%; positive predictive value, 52.6%; negative predictive value, 100.0%).ConclusionThe AUDIT-KR has high reliability and validity for identifying AUD according to DSM-5 criteria.

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“…College students with drinking problems as indicated by higher AUDIT scores showed impulsive decision making in a discounting task and diminished inhibitory control in a go/no-go task (Murphy and Garavan, 2011). The AUDIT score has been used as an outcome measure to identify young adults who developed alcohol dependence (Foxcroft et al, 2015), and to evaluate at-risk drinking in individuals with comorbid depression (van den Berg et al, 2014) and the interactive effects of cumulative stress and impulsivity on alcohol consumption (Fox et al, 2010). By combining the AUDIT and clinical assessment of alcohol use, we may examine the effects of drinking problems and duration of use on inhibitory control.…”

Section: Introductionmentioning

confidence: 99%

Association of Drinking Problems and Duration of Alcohol Use to Inhibitory Control in Nondependent Young Adult Social Drinkers

Zhang

Chao

et al. 2016

Alcoholism Clin & Exp Res

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Background Deficits in inhibitory control have been widely implicated in alcohol misuse. However, the literature does not readily distinguish the effects of drinking problems and chronic alcohol use. Here, we examined how years of drinking and the Alcohol Use Disorders Identification Test (AUDIT) score each influences the cerebral responses to inhibitory control in non-dependent drinkers. Methods Fifty-seven adult drinkers and 57 age and gender matched non-drinkers participated in one 40-minute fMRI scan of the stop signal task. Data were pre-processed and modeled using SPM8. In a regression model, we contrasted stop and go success trials for individuals and examined activities of response inhibition each in link with the AUDIT score and years of alcohol use in group analyses. We specified the effects of duration of use by contrasting regional activations of drinkers and age-related changes in non-drinkers. In mediation analyses, we investigated how regional activities mediate the relationship between drinking problems and response inhibition. Results Higher AUDIT score but not years of drinking was positively correlated with prolonged stop signal reaction time (SSRT) and diminished responses in the cerebellum, thalamus, frontal and parietal regions, independent of years of alcohol use. Further, activity of the thalamus, anterior cingulate cortex, and pre-supplementary motor area significantly mediates the association, bidirectionally, between the AUDIT score and SSRT. The duration of alcohol use was associated with decreased activation in the right inferior frontal gyrus extending to superior temporal gyrus, which was not observed for age-related changes in non-drinkers. Conclusions The results distinguished the association of drinking problems and years of alcohol use to inhibitory control in young adult non-dependent drinkers. These new findings extend the imaging literature of alcohol misuse and may have implications for treatment to prevent the escalation from social to dependent drinking. More research is needed to confirm age-independent neural correlates of years of alcohol use.

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Accuracy of Alcohol Use Disorders Identification Test for Detecting Problem Drinking in 18–35 Year-Olds in England: Method Comparison Study

Cited by 36 publications

References 20 publications

Alterations of resting state functional network connectivity in the brain of nicotine and alcohol users

Alterations of resting state functional network connectivity in the brain of nicotine and alcohol users

Validity of Alcohol Use Disorder Identification Test-Korean Revised Version for Screening Alcohol Use Disorder according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition Criteria

Association of Drinking Problems and Duration of Alcohol Use to Inhibitory Control in Nondependent Young Adult Social Drinkers

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