Accuracy of admission and clinical diagnosis of tumours as revealed by 2000 autopsies

Szende, Béla; Kendrey, G; Lapis, K; Roe, F. J. C.; P, Lee

doi:10.1016/0959-8049(96)00006-8

Cited by 12 publications

(9 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study we observed a significantly higher number of distant (extrathoracic) and total number of metastatic sites with increasing stages (p = 0.004 and 0.05, respectively), (Table 4). Despite increasing use of sophisticated non-invasive methods for staging, diagnostic inaccuracy still occurs in up to 20% of patients compared to autopsy findings (12,14).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the declining autopsy rates attributable to changes in the legal basis and the general attitude in the population severely hamper autopsy studies now and are likely to do so in the future (9 -11), making it interesting to describe such data while this is still possible. Previous large autopsy series are mostly collected from geographic regions, but unfortunately, without pretreatment or uniform clinical characteristics (12). Discrepancies between clinical diagnosis or even death certificates are still common in up to 20% of patients presented for autopsy (13,14).…”

Section: Original Articlementioning

confidence: 99%

See 1 more Smart Citation

Metastatic Pattern in Non-resectable Non-small Cell Lung Cancer

Stenbygaard

Sørensen²,

Larsen³

et al. 1999

Acta Oncologica

View full text Add to dashboard Cite

This study describes the metastatic pattern at autopsy in patients with non-resectable non-small cell lung cancer (NSCLC) and evaluates the impact of various pretreatment variables and treatment outcomes on the metastatic spread. In eight phase II chemotherapy trials from 1985 through 1993, 337 patients were treated and 51 autopsies were performed (autopsy rate 15%). The male/female ratio was 31/20, median age 56 years (range 36-71), response rate to chemotherapy 8%, and median survival 88 days (range 3-899). Histologic types included adenocarcinoma, 31 cases (60%), squamous cell carcinoma, 9 cases (18%), large cell carcinoma, 9 cases (18%), and unclassified NSCLC, 2 cases (4%). Patients who were autopsied had a shorter median survival than patients without autopsy (p = 0.002, log-rank test). Most commonly involved metastatic sites found at autopsy were mediastinal lymph nodes (84%), pleura (51%), liver (47%), bone (34%), brain (32%), pericardium (29%), adrenals (29%). The median number of involved organs was 5 (range 1-16), with a median of 3 intrathoracic sites (range 1-8) and 2 extrathoracic sites (range 0-11). Patients who initially had metastatic NSCLC also had significantly more metastatic sites at autopsy both extrathoracic (p = 0.004) and totally (p = 0.03) compared to patients with locally advanced disease. No other relation to pretreatment variables was found.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Original Articlementioning

confidence: 99%

Metastatic Pattern in Non-resectable Non-small Cell Lung Cancer

Stenbygaard

Sørensen²,

Larsen³

et al. 1999

Acta Oncologica

View full text Add to dashboard Cite

show abstract

“…After performing 300 echopsies followed by complete autopsies, we have improved our original results to reach a concordance rate of 83% between the two techniques for the main diagnoses. Correlation is excellent for all the organs and systems; our worst results are obtained for diseases of the gastrointestinal tract, but these are estimated to cause only 14% of deaths 4 and should therefore have little influence on the global accuracy of the technique. Moreover, we have recently started to use an automatic instrument for sample taking [Pro‐Mag I 2,5 Automatic Biopsy instrument, Wacreees (MD‐Tech, Gainesville, FL, USA)], coupled to the Tru‐cut needle, that greatly simplifies and improves sampling.…”

mentioning

confidence: 81%

Ultrasonographic autopsy

Fariña¹,

Millana²,

Fernández-Aceñero³

2004

Histopathology

View full text Add to dashboard Cite

“…These differences may be attributed to differences in data collection methodology and at least partly to the relatively high autopsy rate for hospital deaths in Hungary which leads to a higher likelihood of diagnosing post-mortem LC, than in other countries with lower autopsy rates [European Health Info Gateway, Bogos 2019]. This hypothesis is supported by several studies which suggest that post-mortem diagnosed LC may account for a clinically relevant proportion of all LC cases [McFarlane et al, 1986, Kendrey et al, 1996, Marel et al, 2015, Egerváry et al, 2000. McFarlane et al conducted a review of post-mortem reports at a university hospital and found that 28% of primary lung cancers detected during autopsy had not been diagnosed while the patient was still alive [McFarlane et al, 1986].…”

Section: Introductionmentioning

confidence: 97%

“…McFarlane et al conducted a review of post-mortem reports at a university hospital and found that 28% of primary lung cancers detected during autopsy had not been diagnosed while the patient was still alive [McFarlane et al, 1986]. A Hungarian study based on 2,000 autopsies performed at two university hospitals found that 59% of LC cases were newly detected during autopsy, raising attention to the common misdiagnosis of the disease [Szende B et al, 1996]. In 2000, Egerváry et al examined 250 consecutive autopsies in a specialized pulmonology center in Hungary and found that the false negative rate for LC diagnosis was 9%, however, Marel et al reported a much higher proportion of undiagnosed LC (44%) in a 2-year study comparing autopsy findings with clinical data in 2015 [Egerváry et al, 2000, Marel et al, 2015.…”

Section: Introductionmentioning

confidence: 99%

Underlying reasons for post-mortem diagnosed lung cancer cases – A robust retrospective comparative study from Hungary (HULC study)

Kiss

Bogos

Tamási

et al. 2022

Preprint

View full text Add to dashboard Cite

Objective The Hungarian Undiagnosed Lung Cancer (HULC) study aimed to explore the potential reasons for missed LC diagnosis by comparing healthcare and socio–economic data among patients with post –mortem diagnosed LC with those who were diagnosed with LC during their lives. Methods This nationwide, retrospective study used the databases of the Hungarian Central Statistical Office (HCSO) and National Health Insurance Fund (NHIF) to identify patients who died between January 1, 2019 and December 31, 2019 and were diagnosed with lung cancer post-mortem (population A) or during their lifetime (population B). Patient characteristics, socio –economic factors, and healthcare resource utilization (HCRU) data were compared between the diagnosed and undiagnosed patient population. Results During the study period, 8,435 patients were identified from the HCSO database with LC as the cause of death, of whom 1,203 (14.24%) had no LC –related ICD code records in the NHIF database during their lives (post-mortem diagnosed LC population). Post –mortem diagnosed LC patients were significantly older than patients diagnosed while still alive (mean age 71.20 vs. 68.69 years, p<0.001), with a more pronounced age difference among female patients (difference: 4.57 years, p<0.001), and had significantly fewer GP and specialist visits, X –ray and CT scans within 7 to 24 months and 6 months before death, although the differences in GP and specialist visits within 7 –24 months did not seem clinically relevant. Patients diagnosed with LC while still alive were more likely to be married (47.62% vs. 33.49%), had higher educational attainment, and had more children, than patients diagnosed with LC post –mortem. Conclusions Post-mortem diagnosed lung cancer accounts for 14.24% of total lung cancer mortality in Hungary. This study provides valuable insights into patient characteristics, socio –economic factors, and HCRU data potentially associated with a high risk of lung cancer misdiagnosis.

show abstract

Accuracy of admission and clinical diagnosis of tumours as revealed by 2000 autopsies

Cited by 12 publications

References 13 publications

Metastatic Pattern in Non-resectable Non-small Cell Lung Cancer

Metastatic Pattern in Non-resectable Non-small Cell Lung Cancer

Ultrasonographic autopsy

Underlying reasons for post-mortem diagnosed lung cancer cases – A robust retrospective comparative study from Hungary (HULC study)

Contact Info

Product

Resources

About