Accuracy of a New Non-Invasive Oxygen Saturation Monitor

Sarnquist, Frank H.; Todd, Christine; Whitcher, Charles E.

doi:10.1097/00000542-198009001-00163

Cited by 27 publications

(6 citation statements)

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“…A commonly accepted limitation of the two-wavelength oximetry technique is the tendency to overestimate the true blood oxygen saturation particularly at lower oxygen saturations. 28 This could explain the higher venular oxygen saturation measurements in normal and glaucoma patients reported in these studies compared with our study. The relative difference in the venular …”

Section: Discussioncontrasting

confidence: 49%

Oxygen saturation measurements of the retinal vasculature in treated asymmetrical primary open-angle glaucoma using hyperspectral imaging

Mordant

Alabboud

Muyo

et al. 2014

Eye

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Purpose To determine whether there are differences in retinal vascular oxygen saturation measurements, estimated using a hyperspectral fundus camera, between normal eyes and treated eyes of subjects with asymmetrical primary open-angle glaucoma (POAG). Methods A noninvasive hyperspectral fundus camera was used to acquire spectral images of the retina at wavelengths between 556 and 650 nm in 2-nm increments. In total, 14 normal eyes and both eyes of 11 treated POAG subjects were imaged and analyzed using algorithms that use the spectral variation of the optical densities of blood vessels to estimate the oxygen saturation of blood within the retinal vasculature. In the treated POAG group, each of the eyes were categorized, based on the mean deviation of the Humphrey visual-field analyzer result, as either more-advanced or less-advanced, glaucomatous eyes. Unpaired t-tests (twotailed) with Welch's correction were used to compare the mean oxygen saturation between the normal subjects and the treated POAG subgroups. Results In less-advanced and moreadvanced-treated POAG eyes, mean retinal venular oxygen saturations (48.2 ± 21.6% and 42.6 ± 18.8%, respectively) were significantly higher than in normal eyes (27.9 ± 9.9%; P ¼ 0.03 and 0.01, respectively). Arteriolar oxygen saturation was not significantly different between normal eyes and treated POAG eyes. ConclusionsThe increased oxygen saturation of the retinal venules in advancedtreated POAG eyes may indicate reduced metabolic consumption of oxygen in the inner retinal tissues.

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Section: Discussioncontrasting

confidence: 49%

Oxygen saturation measurements of the retinal vasculature in treated asymmetrical primary open-angle glaucoma using hyperspectral imaging

Mordant

Alabboud

Muyo

et al. 2014

Eye

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“…Using the device, the effect of multiple scattering was successfully compensated for, as was previously reported by Shimada et al [ 10 ]. The accuracy of measurements by OXIMET has been reported by Yoshiya et al [ 11 ] and Sarnquist et al [ 12 ]. The 1980 report by Yoshiya et al [ 11 ] has the honor of being the first publication in English to introduce pulse oximetry as reported by E. C. Jr. Pierce at the 34 th E.A.…”

Section: The Development Of Pulse Oximeters In Japan: Good Competitors Nihon Kohden and Minolta Cameramentioning

confidence: 71%

“…A large Japanese trading company tried to sell Minolta’s OXIMET-1471 pulse oximeter in the US, and in connection with this, they offered use of the machine for evaluation to an anesthesiologist (Dr. Charles Whitcher) at Stanford University in 1977 and it was used clinically [ 12 ]. The development team at Minolta focused on scientific analysis of the tendency to overestimate at low oxygenation levels, but they were not particularly interested in making improvements to make the machine easier to use on patients in a clinical setting.…”

Section: Pulse Oximeters: the Invention That Changed The Paradigm Of Patient Safety Around The World—in Summary And In Closing This Specimentioning

confidence: 99%

Tribute to Dr. Takuo Aoyagi, inventor of pulse oximetry

et al. 2021

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Introduction Dr. Takuo Aoyagi invented pulse oximetry in 1974. Pulse oximeters are widely used worldwide, most recently making headlines during the COVID-19 pandemic. Dr. Aoyagi passed away on April 18, 2020, aware of the significance of his invention, but still actively searching for the theory that would take his invention to new heights. Method Many people who knew Dr. Aoyagi, or knew of him and his invention, agreed to participate in this tribute to his work. The authors, from Japan and around the world, represent all aspects of the development of medical devices, including scientists and engineers, clinicians, academics, business people, and clinical practitioners. Results While the idea of pulse oximetry originated in Japan, device development lagged in Japan due to a lack of business, clinical, and academic interest. Awareness of the importance of anesthesia safety in the US, due to academic foresight and media attention, in combination with excellence in technological innovation, led to widespread use of pulse oximetry around the world. Conclusion Dr. Aoyagi’s final wish was to find a theory of pulse oximetry. We hope this tribute to him and his invention will inspire a new generation of scientists, clinicians, and related organizations to secure the foundation of the theory.

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“…The phenomenon of overestimating the true oxygen saturation has been reported in studies on other types of photometric oximeters. Sarnquist et al 49 reported that pulse oximeters overestimate the actual oxygen saturation, with an average reading of 70% at 50% actual oxygen saturation. This overestimation by pulse oximeters is thought to be caused by the scattering of red or infrared light in the blood vessels.…”

Section: Discussionmentioning

confidence: 99%