Accuracy of a new bedside method for estimation of circulating blood volume

Christensen, P.; J, Waever Rasmussen; S, Winther Henneberg

doi:10.1097/00003246-199310000-00023

Cited by 21 publications

(19 citation statements)

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“…CO left in the rebreathing system after 10 min of controlled ventilation, measured by spectrophotometry, was found to be in the order of 0.2–0.6% and was thus ignored. Blood‐ (BV) and plasma volumes (PV) were calculated from determination of V RBC , Hb and Hct values (9, 14–16). To assess the real PV within the animal during CPB, the volumes were corrected for the actual fluid volume present in the extracorporeal circuit at the different time intervals.…”

Section: Methodsmentioning

confidence: 99%

Fluid extravasation during cardiopulmonary bypass in piglets – effects of hypothermia and different cooling protocols

Farstad

Heltne

Rynning

et al. 2003

Acta Anaesthesiol Scand

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Section: Methodsmentioning

confidence: 99%

Fluid extravasation during cardiopulmonary bypass in piglets – effects of hypothermia and different cooling protocols

Farstad

Heltne

Rynning

et al. 2003

Acta Anaesthesiol Scand

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“…Concentration-dependent parameters exhibit large within-day biological variations (Hilderink et al 2017) and do not indicate the absolute values. An accurate method for measuring the total Hbmass and total BV could provide a potentially useful clinical tool for monitoring BV and fluid and blood transfusion management in surgical and intensive care practices (Fukui and Shigemi 1989;Christensen et al 1993;Jones and Wardrop 2000). Precise knowledge of Hbmass and BV contribute to the diagnosis of blood disorders, such as anemia, polycythemia vera, or hemodilution, in patients with chronic heart failure (Adlbrecht et al 2008;Ahlgrim et al 2014).…”

Section: Reliability and Validitymentioning

confidence: 99%

“…The estimation of hemoglobin mass (Hbmass) and blood volume (BV) is relevant in the clinic (Christensen et al. ; Jones and Wardrop ; Fouad‐Tarazi et al. ; Ahlgrim et al.…”

Section: Introductionmentioning

confidence: 99%

“…The estimation of hemoglobin mass (Hbmass) and blood volume (BV) is relevant in the clinic (Christensen et al 1993;Jones and Wardrop 2000;Fouad-Tarazi et al 2007;Ahlgrim et al 2014;Karlsen et al 2016) and for exercise physiology. However, currently no method for determination of hemoglobin mass is used frequently in clinical settings.…”

Section: Introductionmentioning

confidence: 99%

“…In commonly used CO rebreathing protocols the CO is administered as a bolus into a rebreathing curcuit (Christensen et al 1993;Burge and Skinner 1995;Schmidt and Prommer 2005). Two versions of the CO rebreathing method are used.…”

Section: Introductionmentioning

confidence: 99%

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Determination of hemoglobin mass in humans by measurement of CO uptake during inhalation of a CO-air mixture: a proof of concept study

Falz

Busse

2018

Physiol Rep

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Measuring hemoglobin mass (Hbmass) using the carbon monoxide (CO) bolus rebreathing method is frequently used in research but has yet to be widely used in the clinical practice. The estimation of an adequate CO bolus may be difficult in patients with unknown Hbmass. In the present pilot study, a progressive inhalation technique for CO that leads to a linear individual adjusted COHb increase was evaluated. Sixteen healthy test subjects participated in the study (preliminary investigation: six; main study: ten). The reliability and validity of the new method were evaluated using multiple measurements of Hbmass with and without a defined blood donation and compared to a CO bolus method. The participants inhaled a CO‐air mixture (CO concentration: 1500 ppm) for a specific breathing duration. The CO uptake and COHb change were determined simultaneously. The typical error (reliability) in the repeated measurements was 2.4% (CI ± 4.7). The mean difference between the new method and the bolus method was 34 g (±41; P = 0.026). The measured hemoglobin loss in 490 mL of blood was 74 g (±35), and the calculated hemoglobin loss was 77 g (±4) (mean difference 3 g ± 34; P = 0.820). The new method was reliable and valid in a proof of concept study with healthy subjects. The total amount of CO and as a result the COHb increase is individually adjustable. Future studies in clinical settings are needed to determine if the method could be used in disease‐specific pathologies associated with changes in Hbmass.

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Accuracy of carboxyhe-moglobin dilution method for the measurement of circulating blood volume

Ohki

Kunimoto

Isa

et al. 2000

Can J Anesth/J Can Anesth

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Accuracy of a new bedside method for estimation of circulating blood volume

Cited by 21 publications

References 0 publications

Fluid extravasation during cardiopulmonary bypass in piglets – effects of hypothermia and different cooling protocols

Fluid extravasation during cardiopulmonary bypass in piglets – effects of hypothermia and different cooling protocols

Determination of hemoglobin mass in humans by measurement of CO uptake during inhalation of a CO-air mixture: a proof of concept study

Accuracy of carboxyhe-moglobin dilution method for the measurement of circulating blood volume

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