In this paper, based on the teaching status of microcomputer principle and interface technology course, a hybrid teaching method based on MOOC "Microcomputer Principle and Interface Technology" course is proposed. The teaching method combines the MOOC platform with the traditional classroom, and makes full use of the MOOC teaching resources to achieve efficient classroom learning. Students need to learn MOOC content in advance, and teachers need to prepare lessons according to the MOOC learning situation of the students. It has been proved by practice that this teaching method makes the lectures in the classroom more prominent, the learning efficiency is improved, the students' grades are generally improved, and the overall teaching effect is good.