Accuracy assessment of bolus and basal rate delivery of different insulin pump systems used in insulin pump therapy of children and adolescents

Evaluation of the Accuracy of Current Tubeless Pumps for Continuous Subcutaneous Insulin Infusion

“…In the present analysis, increasing accuracy with larger insulin doses was observed for the new pumps for bolus as well as basal rate delivery, confirming several other investigations. [9][10][11] The mean deviation of boluses from target was less than 5% for all bolus sizes in all pumps.…”

“…An adequate test setting for tubeless pumps is still under debate, especially as conflicting results are reported for OP from different working groups using different experimental designs. [4][5][6][7][8][9][10][11] In our previous tests, OP was only compared to durable pumps and showed inferior accuracy, giving rise to doubts about the experimental set-up. However, since the same delivery patterns, (large and recurrent variation between 1-h windows), were only observed in one of the two new pumps tested with the same setup, and as parts of the newly obtained results were comparable to those of durable pumps, these methodological doubts are now diminished.…”

“…The established tubeless pump Omnipod ® (Eros version, Insulet Corporation, Acton, MA) (OP) was previously tested 7,10 and these data were used for comparative analysis. Adjusting for multiple testing, p-values <0.025 were regarded as statistically significant.…”

“…For a comparative analysis of current tubeless pumps, previously published data for a third and established tubeless pump were included along with a new evaluation of bolus and basal rate delivery, as well as occlusion detection time. 7,10,17 The frequency of bolus values within a range of ±15% of the target was significantly greater with ACS compared to A6 and OP for 0.2 U and 1 U boluses (p<0.001) and OP was more accurate than A6 (0.2 U: p<0.001; 1 U: p=0.007) ( Figure 3). For 10 U bolus deliveries, there was no significant difference.…”

“…3 Although evidence regarding clinical relevance is scarce, accuracy and reliability of insulin delivery by insulin pumps are considered important and have been tested by different study groups in recent times. [4][5][6][7][8][9][10][11] In this context, there have been comparisons of tubeless pumps, also known as patch pumps, and durable pumps with one tubeless pump often showing inferior accuracy. 5,7,10,11 However, the selection of tubeless pumps is more limited compared to durable pumps, leading to the first available tubeless pump being most frequently used as a comparator.…”