Accuracy and uniformity of the nomenclature of biogenic amines and polyamines in metabolomics studies: A preliminary study

Abstract

Metabolomics is one of the newest areas in biochemistry dedicated to investigating small biomolecules in biofluids, tissues, and cells. Cutting edge instruments used in metabolomics studies make it possible to identify thousands of biomolecules and determine their interactions with biological networks. This tremendous area has increased the significance of accurate chemical nomenclature of compounds. Therefore, the classification of the organic molecules has become one of the most important issues in the field. Biogenic amines are nitrogenous compounds of low molecular weight formed by the decarboxylation of amino acids or by the amination and the transamination of aldehydes and ketones during normal metabolic processes. This letter covers the topic of nomenclature with respect to the current usage of biogenic amines in scientific literature. We use metabolomics as an example of field reporting data on trace levels of molecules that may be miscategorized in primary literature. We suggest that the incorrect classification of molecules will influence science education adversely because resources used for teaching are drawn from primary literature references that may contain errors.

Profile Characterization of Biogenic Amines in Glioblastoma Patients Undergoing Standard-of-Care Treatment

“…Biogenic amines are an important class of metabolites as they play critical roles in cell metabolism, cell growth, and intracellular communication [ 7 ]. They are defined as nitrogenous organic compounds—primary (R-NH 2 ), secondary (R 2 -NH), or tertiary (R 3 -N) amine structures—with known physiologic effects [ 8 , 8 ]. In the nervous system, they function in numerous processes, including protein synthesis and neurotransmission.…”