Accuracy and response time of dual biomarker model of insulin‐like growth factor binding protein‐1/ alpha fetoprotein (Amnioquick duo+) in comparison to placental alpha‐microglobulin‐1 test in diagnosis of premature rupture of membranes

Eleje, George Uchenna; Ezugwu, Euzebus Chinonye; Eke, Ahizechukwu C.; Ikechebelu, Joseph Ifeanyichukwu; Ezeama, Chukwuemeka Okwudili; Ezebialu, Ifeanyichukwu U.; Ojiegbe, Nnabuike O.; Obiora, Chukwudi Celestine; Okafor, CI; Udigwe, Gerald Okanandu; Nwosu, Betrand Obi; Ezugwu, Frank Okechukwu

doi:10.1111/jog.13296

Cited by 9 publications

(9 citation statements)

References 33 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…23 Several factors have been considered to explain these conflicting results, including the detec- Although there are no data, including a cost-effectiveness analysis, supporting the use of AmnioQuick Duo+ instead of PAMG-1, a previous study has reported that AmnioQuick Duo+ has a faster response time. 14 In the present study, noninvasive assessment by AmnioQuick Duo+ accurately identified genuine PROM regardless of the duration of rupture or gestational age at rupture. AmnioQuick Duo+ also identified women with PROM who did not go on to deliver within the next 7 days.…”

Section: Discussionsupporting

confidence: 51%

“…Although there are no data, including a cost‐effectiveness analysis, supporting the use of AmnioQuick Duo+ instead of PAMG‐1, a previous study has reported that AmnioQuick Duo+ has a faster response time . In the present study, noninvasive assessment by AmnioQuick Duo+ accurately identified genuine PROM regardless of the duration of rupture or gestational age at rupture.…”

Section: Discussionmentioning

confidence: 46%

“…On the basis of other studies, the ultimate determination of whether or not the women had PROM at first presentation was made after delivery. PROM was diagnosed if any two of the following criteria were fulfilled: delivery within 48 hours to 7 days (depending on gestational age); clinical evidence of chorioamnionitis; perceptibly ruptured membranes at time of delivery; and adverse perinatal/neonatal outcomes strongly associated with prolonged PROM.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Performance indices of AmnioQuick Duo+ versus placental α‐microglobulin‐1 tests for women with prolonged premature rupture of membranes

Eleje

Ezugwu

Ezebialu

et al. 2018

Intl J Gynecology & Obste

View full text Add to dashboard Cite

Objective To compare AmnioQuick Duo+ versus the placental α‐microglobulin‐1 (PAMG‐1) test for diagnosis of prolonged premature rupture of membranes (PROM). Methods A multicenter prospective cohort study included women with suspected PROM at six tertiary institutions in southern Nigeria between January 1 and December 31, 2015. The inclusion criteria were features of PROM lasting at least 24 hours and a pregnancy duration of more than 24 weeks. AmnioQuick Duo+ (Biosynex, Strasbourg, France) and PAMG‐1 (AmniSure International, Boston, USA) tests were used to diagnose PROM, which was confirmed after delivery by any two of the following criteria: delivery within 48 hours to 7 days, chorioamnionitis, membranes perceptibly ruptured at delivery, and adverse perinatal outcomes considerably associated with prolonged PROM. Results Of 100 women assessed for eligibility, 99 were included. Sensitivity, specificity, and accuracy were, respectively, 97.3%, 100%, and 95.9% for AmnioQuick Duo+, and 93.2%, 100%, and 90.4% for PAMG‐1. The differences were not significant and the diagnostic discordant rate between the two tests was 3.1%. In equivocal cases (i.e., negative pooling test result), AmnioQuick Duo+ and PAMG‐1 performed equally (diagnostic accuracy, 100% vs 97.7%; P>0.99). Conclusion For diagnosis of PROM, AmnioQuick Duo+ was found to be non‐inferior and comparable in accuracy to the PAMG‐1 test, with a diagnostic discordance rate of 3.1%.

show abstract

Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 46%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Performance indices of AmnioQuick Duo+ versus placental α‐microglobulin‐1 tests for women with prolonged premature rupture of membranes

Eleje

Ezugwu

Ezebialu

et al. 2018

Intl J Gynecology & Obste

View full text Add to dashboard Cite

show abstract

“…Gestational age was assessed according to the last menstrual period, PPROM was diagnosed by clinical standards using speculoscopy to assess amniotic fluid leakage from the cervix and then analyzed using Amnioquick ® , a quick test based on the detection of IGFBP-1 (insulin-like growth factor binding protein-1) in high concentrations in amniotic fluid, with a cut-off of 5 ng/mL to avoid interference with contaminants (semen, urine, or blood) [20]. Women with a proven diagnosis of PPROM were hospitalized and referred to our fetal medicine unit for further evaluation and treatment.…”

Section: Methodsmentioning

confidence: 99%

Maternal Serum Interleukin-6: A Non-Invasive Predictor of Histological Chorioamnionitis in Women with Preterm-Prelabor Rupture of Membranes

et al. 2018

View full text Add to dashboard Cite

Objective: To assess the added value of maternal serum levels of IL-6 in women with preterm-prelabor rupture of membranes (PPROM) as a non-invasive test for the prediction of histological chorioamnionitis (HCA). Methods: This was a prospective cohort study of pregnant women between 20 + 0 and 36 + 6 weeks of gestation with a confirmed diagnosis of PPROM. Logistic regression models were created for the prediction of HCA and compared by assessing the improvement in their Naegelkerke R² as a measure of goodness of fit. Predictive performance of all models was assessed by receiver operating characteristics curve (ROC) analysis and compared by the DeLong method. Results: From 47 women with PPROM, 31 (66%) developed HCA. Maternal serum IL-6 ≥19.5 pg/dL was the best cut-off point for the prediction of HCA (OR = 15; 95% CI: 3.6–61; p < 0.01). A model comprising maternal characteristics and IL-6 ≥19.5 pg/dL showed an area under the curve of 0.85 (95% CI: 0.74–0.95), significantly improving the previous models of IL-6 ≥19.5 pg/dL (R²: 23.3 vs. 34.1%; p = 0.01) or maternal characteristics (R²: 8.4 vs. 34.1%; p < 0.01). Conclusions: A model comprising maternal serum levels of IL-6 plus maternal characteristics proves to be a good non-invasive predictor of HCA.

show abstract

“…Few studies have performed a direct comparison simultaneously between the two immunochromatographic tests, as we did in the present study . With the aim of facilitating an understanding and comparative analysis with our research, we present these previous studies in detail in Table .…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of Insulin‐like growth factor binding protein‐1, placental alpha‐microglobulin‐1, phenol and pH for the diagnosis of preterm premature rupture of membranes between 20 and 36 weeks

Galletta

Bittar

Rodrigues

et al. 2019

J of Obstet and Gynaecol

View full text Add to dashboard Cite

Aim: Preterm premature rupture of membranes (PPROM) is responsible for approximately one-third of premature births worldwide, and although the diagnosis is often straightforward, this condition can still present difficulties. The purpose of this research was to compare the accuracy of several PPROM diagnostic tests. Methods: A total of 94 pregnant women with clinical suspicion of PPROM who were between 20 and 36 weeks of pregnancy were examined by vaginal speculum, and tests were performed for phenol, pH, insulin-like growth factor binding protein-1 (IGFBP-1) and placental alpha-microglobulin-1 (PAMG-1). All patients were followed up until the diagnosis was fully defined, and a diagnosis of PROM was confirmed by a definitive evolution of the clinical symptoms (visualization of vaginal amniotic fluid or persistence of oligohydramnios). Results: After excluding the cases that could not be definitively diagnosed, a good diagnostic performance of the immunochromatographic tests was observed that was superior to that of the clinical tests. Similar accuracies were observed for IGFBP-1 (98.7%) and PAMG-1 (93.9%). However, while the IGFBP-1 test differed from a vaginal pH ≥7 (88.9%) and the phenol test (85.7%), this did not occur for the PAMG-1 test. The performance of the tests was modified only by the presence of bleeding (with lower specificity rates for pH and phenol), without interference of gestational age or maternal morbidities. Conclusion: Immunochromatographic tests are good tools but should be used sparingly in resource-poor settings because they are expensive, and there is no significant difference between PAMG-1 and traditional tests.Comparative analysis of PPROM markers patients signed an informed consent form after which they were enrolled in the study.

show abstract

Accuracy and response time of dual biomarker model of insulin‐like growth factor binding protein‐1/ alpha fetoprotein (Amnioquick duo+) in comparison to placental alpha‐microglobulin‐1 test in diagnosis of premature rupture of membranes

Cited by 9 publications

References 33 publications

Performance indices of AmnioQuick Duo+ versus placental α‐microglobulin‐1 tests for women with prolonged premature rupture of membranes

Performance indices of AmnioQuick Duo+ versus placental α‐microglobulin‐1 tests for women with prolonged premature rupture of membranes

Maternal Serum Interleukin-6: A Non-Invasive Predictor of Histological Chorioamnionitis in Women with Preterm-Prelabor Rupture of Membranes

Comparative analysis of Insulin‐like growth factor binding protein‐1, placental alpha‐microglobulin‐1, phenol and pH for the diagnosis of preterm premature rupture of membranes between 20 and 36 weeks

Contact Info

Product

Resources

About