Accuracy and precision of using partial-mouth recordings to study the prevalence, extent and risk associations of untreated periodontitis

Alawaji, Yasmine N.; Mostafa, Nesrine; Carvalho, Ricardo Marins de; Alshammari, Abdulsalam; Aleksejūnienė, Jolanta

doi:10.1016/j.sdentj.2021.12.005

Cited by 4 publications

(8 citation statements)

References 25 publications

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“…A majority of studies limited the inclusion of subjects if they had ≥6 teeth remaining. Few studies had strict eligibility criteria such as subjects being required to have ≥16-24 teeth present [24][25][26], limited to subjects with periodontitis [25], or untreated individuals [27,28], which can limit their external validity.…”

Section: Study Selectionmentioning

confidence: 99%

“…e measurement of these risk determinants varied among studies. Diabetes mellitus was either defined as present/absent [13,14] or based on self-reported glycemic control [28]. Obesity was defined as present/absent [28] or based on Body Mass Index [13,14].…”

Section: Periodontitis-related Risk Associationsmentioning

confidence: 99%

“…Diabetes mellitus was either defined as present/absent [13,14] or based on self-reported glycemic control [28]. Obesity was defined as present/absent [28] or based on Body Mass Index [13,14]. Current smoking was defined as currently smoking any number of cigarettes daily [28] or smoking ≥100 cigarettes during the lifetime [13].…”

Section: Periodontitis-related Risk Associationsmentioning

confidence: 99%

“…Obesity was defined as present/absent [28] or based on Body Mass Index [13,14]. Current smoking was defined as currently smoking any number of cigarettes daily [28] or smoking ≥100 cigarettes during the lifetime [13].…”

Section: Periodontitis-related Risk Associationsmentioning

confidence: 99%

“…Two studies analyzed the precision of estimating periodontitis extent and/or severity and did not find clear patterns based on age cohorts [9,27]. One study [28]…”

Section: Risk Associations With Periodontitismentioning

confidence: 99%

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Accuracy of Estimating Periodontitis and Its Risk Association Using Partial-Mouth Recordings for Surveillance Studies: A Systematic Review and Meta-Analysis

Alawaji

Alshammari

Aleksejūnienė

2022

International Journal of Dentistry

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Objectives. Our aim is to conduct an up-to-date systematic review and meta-analysis pertaining to the accuracy of using the partial-mouth recording protocol (PRP) in surveillance studies to estimate the periodontitis prevalence, extent, severity, and its risk associations. Methods. Medline and Embase databases were searched for studies which assessed the periodontitis prevalence, severity, extent, or its risk associations using PRPs versus full-mouth recording protocols (FRPs); searches were conducted up until May 26, 2021. The risk of bias and the applicability of the studies were assessed using the QUADAS-2 tool. Both qualitative data synthesis and quantitative data synthesis were performed, and comparisons were done for the accuracy and precision of PRPs for different periodontitis outcomes. The study’s protocol was registered through the International Platform of Registered Systematic Review and Meta-analysis Protocols (registration number: INPLASY202160032). Results. A total of 14 studies were included. The studies had a considerable degree of heterogeneity, along with a moderate risk of bias and applicability concerns. Several factors influenced the accuracy or precision of using PRPs, including the age, distribution of periodontitis in the studied population, PRP selection, total PRP sites, the threshold for minimum sites with CAL, and the severity of periodontitis case definitions. Overall, the PRP with the highest accuracy and precision mainly included (1) a full-mouth protocol at the following partial sites: mesiobuccal-midbuccal-distolingual (MB-B-DL), mesiobuccal-distolingual (MB-DL), mesiobuccal-midbuccal-distobuccal (MB-B-DB), mesiobuccal-distobuccal (MB-DB), and 84 sites using the random site selection method (RSSM) and (2) random-half-mouth (RHM) protocols. Conclusions. The PRPs with the highest overall accuracy and precision in estimating the periodontitis prevalence, extent, severity, and risk associations included the full-mouth assessment at the following partial sites: MB-B-DL, MB-DL, MB-B-DB, MB-DB, and 84 sites using RSSM and RHM protocols.

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Section: Study Selectionmentioning

confidence: 99%

Section: Periodontitis-related Risk Associationsmentioning

confidence: 99%

Section: Periodontitis-related Risk Associationsmentioning

confidence: 99%

Section: Periodontitis-related Risk Associationsmentioning

confidence: 99%

“…Two studies analyzed the precision of estimating periodontitis extent and/or severity and did not find clear patterns based on age cohorts [9,27]. One study [28]…”

Section: Risk Associations With Periodontitismentioning

confidence: 99%

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Accuracy of Estimating Periodontitis and Its Risk Association Using Partial-Mouth Recordings for Surveillance Studies: A Systematic Review and Meta-Analysis

Alawaji

Alshammari

Aleksejūnienė

2022

International Journal of Dentistry

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Serum lipoprotein subfractions are associated with the periodontal status: Results from the population‐based cohort SHIP‐TREND

Kapp,

Holtfreter,

Kocher

et al. 2023

J Clinic Periodontology

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AimTo investigate the medium‐term associations of serum protein subfractions derived from proton nuclear magnetic resonance (1H‐NMR) spectroscopy with periodontitis and tooth loss.Materials and MethodsA total of 3031 participants of the cohort Study of Health in Pomerania (SHIP‐TREND) were included. In addition to conventional serum testing, serum lipoprotein contents and subfractions were analysed by 1H‐NMR spectroscopy. Confounder‐adjusted associations of lipoprotein variables with periodontitis and the number of missing teeth variables were analysed using mixed‐effects models with random intercepts for time across individuals, accounting for multiple testing.ResultsWhile only spurious associations between lipoprotein levels from conventional blood tests were found—that is, triglycerides were associated with mean clinical attachment level (CAL) and low‐density lipoprotein cholesterol/high‐density lipoprotein cholesterol (LDL‐C/HDL‐C) ratio with the number of missing teeth ‐ several associations emerged from serum lipoprotein subfractions derived from 1H‐NMR analysis. Specifically, elevated LDL triglycerides were associated with higher levels of mean probing depth (PD), mean CALs, and increased odds of having <20 teeth. HDL‐4 cholesterol levels were inversely associated with mean PD. Systemic inflammation (C‐reactive protein) might mediate the effects of LDL and HDL triglyceride contents on periodontitis severity.ConclusionsSeveral associations between serum lipoprotein subfractions and periodontitis were observed. As the underlying biochemical mechanisms remain unclear, further research is needed.

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Multiple Imputation for Partial Recording Periodontal Examination Protocols

Preisser

Shing

Qaqish

et al. 2023

JDR Clinical & Translational Research

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Aim: Partial-mouth recording protocols often result in underestimation of population prevalence and extent of periodontitis. We posit that multiple imputation of measures such as clinical attachment loss for nonselected tooth sites in partial-mouth samples can reduce bias in periodontitis estimates. Methods: Multiple imputation for correlated site-level dichotomous outcomes in a generalized estimating equations framework is used to impute site-level binary indicators for clinical attachment loss exceeding a fixed threshold in partial-mouth samples. Periodontitis case definitions are applied to the imputed “complete” dentitions, enabling estimation of prevalence and other summaries of periodontitis for partial-mouth samples as if for full-mouth examinations. A multiple imputation-bootstrap procedure is described and applied for point and variance estimation of these periodontitis measures. The procedure is evaluated with pseudo-partial-mouth samples based on random site selection protocols of 28 to 84 periodontal sites repeatedly generated from full-mouth periodontal examinations of 3,621 participants in the 2013 to 2014 National Health and Nutrition Examination Survey (NHANES) survey. Results: Multiple imputation applied to partial-mouth samples overestimated periodontitis mean extent, defined as the number of sites with clinical attachment loss 3 mm or greater, by 9.5% in random site selection protocols with 84 sites and overestimated prevalence by 5% to 10% in all the evaluated protocols. Conclusions: In the 2013 to 2014 NHANES data, multiple imputation of site-level periodontal indicators provides less biased estimates of periodontitis prevalence and extent than has been reported from estimates based on the direct application of full-mouth case definitions to partial-mouth samples. Multiple imputation provides a promising solution to the longstanding, vexing problem of estimation bias in partial-mouth recording, with potential application to a wide array of case definitions, periodontitis measures, and partial recording protocols. Knowledge Transfer Statement: Partial-mouth sampling, while a resource-efficient strategy for obtaining oral disease estimates, often results in underestimation of periodontitis metrics. Multiple imputation for nonselected periodontal sites produces pseudo-full-mouth data sets that may be analyzed and combined to produce estimates with small bias.

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Accuracy and precision of using partial-mouth recordings to study the prevalence, extent and risk associations of untreated periodontitis

Cited by 4 publications

References 25 publications

Accuracy of Estimating Periodontitis and Its Risk Association Using Partial-Mouth Recordings for Surveillance Studies: A Systematic Review and Meta-Analysis

Accuracy of Estimating Periodontitis and Its Risk Association Using Partial-Mouth Recordings for Surveillance Studies: A Systematic Review and Meta-Analysis

Serum lipoprotein subfractions are associated with the periodontal status: Results from the population‐based cohort SHIP‐TREND

Multiple Imputation for Partial Recording Periodontal Examination Protocols

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