“…IgG is the predominant serum immunoglobulin and has a wide range of functions. The European rabbit (O. cuniculus) has played an important role in immunological research (reviewed in Pinheiro et al, 2011) and is unique in having only one IGHG copy (Knight et al, 1985;Hamers, 1987;Ros et al, 2004;Gertz et al, 2013). The assessment of wild populations and domestic breeds' IgG genetic diversity was previously carried out by serological analyses based on two polymorphisms located to the hinge region (d11/d12) and CH2 domain (e14/e15) (Hamers & Hamers-Casterman, 1965;Dubiski, 1969;Mage, 1981;Esteves et al, 2002Esteves et al, , 2006.…”