Accuracy and consequences of reported target height

Ceconi, Viola; Grigoletto, Veronica; Pellegrin, Maria Chiara; Faleschini, Elena; Barbi, Egidio; Tornese, Gianluca

doi:10.1111/apa.15690

Cited by 4 publications

(4 citation statements)

References 5 publications

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“…Moreover, neither group exceeded their predicted height. The difference between FH and TH was only 1,5 cm in the treated group and 2 cm in the untreatead group, hence, considering that TH is often overestimated (26) there is a possibility that the children actually reached their TH.…”

Section: Final Height In Treated Versus Untreated Groupmentioning

confidence: 89%

“…While interestingly, the difference between FH and TH was insignificant comparing the treated with untreated iCPP girls. Considering that TH was calculated from the heights reported by the parents, which are notoriously overestimated (26), it is almost certain that the actual TH is lower than the calculated TH. And also, the near FH was measured, thus it cannot be excluded that these children would gain at least 1 cm in the following years, therefore the actual FH might be equal or even greater than the mid-parental height in the group of iCPP.…”

Section: Discussionmentioning

confidence: 99%

“…The difference between two groups was significant: FH in children with iCPP was only 1,5 cm below TH while in the nCPP group it was considerably lower at 9 cm below TH. Taking into consideration that TH reported from parental heights is often overestimated (26), it is not unlikely that children with iCPP actually reached their TH in contrast with children with nCPP that were further below their TH. The median difference between FH and PAH was also negative, meaning neither group attained its predicted height.…”

Section: Final Height In Idiopathic Versus Nonidiopathic Cpp Groupmentioning

confidence: 99%

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Final adult height in children with central precocious puberty – a retrospective study

et al. 2022

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Background/AimsCentral precocious puberty (CPP) is due to premature activation of the hypothalamic-pituitary-gonadal axis. It predominantly affects girls. CPP leads to lower final height (FH), yet the treatment benefit in girls between 6 and 8 years is equivocal. Our main goal was to evaluate the effects of gonadotropin-releasing hormone analog (GnRHa) on FH and identify factors that predict FH.MethodsIn a retrospective study, children with CPP (12 boys, 81 girls) that reached FH were included. Their clinical data at diagnosis and up to their final height was compared by descriptive statistics among idiopathic (iCPP) (n=68) and non-idiopathic CPP (nCPP) and between GnRHa treated (n=48) and untreated (n=15) girls with iCPP. The treatment effect of body weight (BW) adjusted GnRHa dosing was evaluated. Univariate linear regression and step-wise multivariable regression including 48 girls with iCPP treated with GnRHa were performed to identify predicting factors for FH.ResultsChildren with idiopathic CPP (iCPP) reached higher FH (p=0.002) than children with non-idiopathic CPP. After the diagnosis, the treated group gained 7.0 cm more than the untreated group. Yet, attributable to individualized decision-making, the FH in both groups was comparable (161.5 cm in treated, 161.0 cm in untreated girls with iCPP), although the onset of menarche was 2.5 years earlier among untreated girls. BW-adjusted dosing suppressed peak luteinizing hormone (LH) below 4.5 IU/L in 95% of children; however, bone age further advanced during therapy in 38% of patients. Predicting factors revealed by multivariable regression were bone age at diagnosis, BMI SDS at diagnosis, LH basal, age at start and cessation of treatment, predicted adult height and target height. (R2 = 0.72).ConclusionChildren with nCPP had worse FH outcome compared to iCPP despite similar CPP onset and therapeutic characteristics. Treatment by GnRHa using BW-adjusted dosing was effective in delaying menarche onset and reaching target height in girls with iCPP. Multiple factors affecting FH outcome indicated individualized decision-making regarding therapeutic intervention remains challenging. In the treated patients, among the factors that can be influenced, height at treatment cessation most significantly influenced the outcome.

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Section: Final Height In Treated Versus Untreated Groupmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Final Height In Idiopathic Versus Nonidiopathic Cpp Groupmentioning

confidence: 99%

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Final adult height in children with central precocious puberty – a retrospective study

et al. 2022

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“…Family history may not be enough to identify all children having a parent with SS if we consider that parents -especially those of children referred for short stature -tend to overestimate their height. [7][8][9][10][11] This study aimed to verify the prevalence of different de nitions of FSS on a cross-sectional cohort of children referred for SS when their height and that of both parents were measured.…”

Section: Introductionmentioning

confidence: 99%

Definition and prevalence of familial short stature

Grigoletto

Occhipinti

Pellegrin

et al. 2020

Preprint

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Objective A significant portion of familial short stature (FSS) cases may not be recognized in clinical practice if the parents’ height is not adequately investigated. This study aimed to verify the prevalence of different definition of FSS on a cross-sectional cohort of children referred for short stature (SS) when their height and that of both parents were measured. Methods We consecutively enrolled 65 individuals referred for SS when both parents were present. We defined “target height related short stature” (TH-SS) when child height SDS was ≤-2 and included in the range of TH (i.e. TH SDS ± 1.5) and “autosomal dominant short stature” (AD-SS) when child and at least one parent heights were ≤-2 SDS. Results On 65 children referred for SS, 48 individuals had a height ≤-2 SDS. Based on measured parents’ heights, 24 children had TH-SS and 16 children AD-SS; 12 children were identified by both TH-SS and AD-SS, while 12 children with TH-SS did not have any of parents with SS. When considering reported parents’ heights, 3 out of 24 children with TH-FSS and 9 out of 16 with AD-FSS would have been missed. Conclusion This study underlines that adequate measurement and consideration of both parents’ height should be part of the clinical evaluation of every children with SS and new definitions should be used to detect and adequately approach the cases of FSS, since the identification of a causative gene in AD-SS can support treatment and follow-up decisions.

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Definition and prevalence of familial short stature

et al. 2021

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Objective To verify the prevalence of novel definitions of familial short stature on a cross-sectional cohort of children referred for short stature when their height and that of both parents were measured. Methods We consecutively enrolled 65 individuals referred for short stature when both parents were present. We defined “target height-related short stature” (TH-SS) when child’s height is ≤ − 2 SDS and included in the range of target height; suspected “autosomal dominant short stature” (AD-SS) when child height and at least one parent height are ≤ − 2 SDS; “constitutional familial short stature” (C-FSS) when a child with TH-SS does not have any parents with height ≤ − 2 SDS. Results Of 65 children referred for SS, 48 individuals had a height ≤ − 2 SDS. Based on the parents’ measured heights, 24 children had TH-SS, 16 subjects AD-SS, and 12 individuals C-FSS. If we had considered only the parents’ reported height, 3 of 24 children with TH-SS, 9 of 16 with AD-SS, and 10 of 12 with C-FSS would have been lost. Conclusion We suggest novel definitions to adequately detect and approach the cases of FSS since C-FSS (25%) might not need any specific investigation, while on the contrary, AD-SS (33%) should undergo genetic evaluation. Moreover, this study underlines that adequate measurement and consideration of children’s and parents’ heights (individually and together) are crucial in the clinical evaluation of every child with short stature.

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Accuracy and consequences of reported target height

Cited by 4 publications

References 5 publications

Final adult height in children with central precocious puberty – a retrospective study

Final adult height in children with central precocious puberty – a retrospective study

Definition and prevalence of familial short stature

Definition and prevalence of familial short stature

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