Accupuncture-like transcutaneous electrical nerve stimulation therapy success using a commercially available unit 8 years post-radiation for xerostomia: a case report

Iovoli, Austin J.; Singh, Anurag K.

doi:10.1017/s1460396917000024

Cited by 6 publications

(5 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diseases. e types of epileptic seizures can be divided into partial seizures, general seizures, and difficult-to-classify seizure types [8]. e socalled partial seizure, also called local seizure, refers to changes in specific symptoms when the seizure begins, and neurons in the cerebral hemisphere are initially activated, including simple partial seizures, complex partial seizures, and second full seizures.…”

Section: Classification Of Epilepsymentioning

confidence: 99%

Clinical Study on Electronic Medical Neuroelectric Stimulation Based on the Internet of Things to Treat Epilepsy Patients with Anxiety and Depression

Zhang¹,

Wang²,

Wang³

et al. 2021

Journal of Healthcare Engineering

View full text Add to dashboard Cite

With the continuous development and improvement of the level of medical technology in our country in recent years, the treatment of epilepsy has been constantly updated and developed. Nerve electrical stimulation is considered to be a very effective method for treating epilepsy with anxiety and depression. There are many traditional methods for the treatment of epilepsy. For example, vagus nerve stimulation (VNS) has been applied earlier, and the therapeutic effect has been confirmed, but it will cause serious complications and is easier to be uncomfortable; deep brain stimulation for epilepsy is still in the immature stage, and there is no final conclusion. Therefore, this article proposes a clinical study on the treatment of patients with epilepsy with anxiety and depression based on the electronic medical nerve stimulation of the Internet of Things. First of all, this article uses the literature method to study the causes of epilepsy and previous treatment methods. Then, we designed an experimental study of epilepsy with depression based on the Internet of Things electronic medical neuroelectric stimulation therapy and selected the core quality of life questionnaire, SDS, and SAS as observation indicators. Finally, the comparison of epilepsy symptoms and depression and anxiety between the control group and the observation group before and after treatment was analyzed. The results of the experiment showed that, among the 50 subjects in the study, the observation group that used electrical nerve stimulation therapy had 5 people who stopped seizures after treatment, accounting for 10%, while in the control group of traditional drug treatment methods, after treatment, only one person stopped the seizure, accounting for 2%. In addition, the SAS and SDS scores of the observation group were also lower than those of the control group. Therefore, the use of nerve electrical stimulation to treat epilepsy with anxiety and depression symptoms has better performance and can help patients recover as soon as possible.

show abstract

Section: Classification Of Epilepsymentioning

confidence: 99%

Clinical Study on Electronic Medical Neuroelectric Stimulation Based on the Internet of Things to Treat Epilepsy Patients with Anxiety and Depression

Zhang¹,

Wang²,

Wang³

et al. 2021

Journal of Healthcare Engineering

View full text Add to dashboard Cite

show abstract

“…Recognizing that the Codetron TENS unit used in all prospective studies (including this one) is no longer in production and that time in clinical practices is limited, our group has described successfully treating a patient with xerostomia by using a protocol for patients to selfadminister ALTENS treatment at home, with a commercially available and cheap device (roughly $300). 16 To further improve the convenience of treatment for these patients, our group would like to further evaluate the efficacy of unmonitored home use of ALTENS by initiating a multiinstitutional study enabling other treatment centers to loan ALTENS units to HNC survivors with xerostomia.…”

Section: Future Directionsmentioning

confidence: 99%

Two- Versus Four-Times Weekly Acupuncture-Like Transcutaneous Electrical Nerve Stimulation for Treatment of Radiation-Induced Xerostomia: A Pilot Study

Iovoli

Ostrowski

Rivers

et al. 2020

The Journal of Alternative and Complementary Medicine

Self Cite

View full text Add to dashboard Cite

Background: Xerostomia occurs in the majority of patients undergoing chemoradiation therapy for head and neck cancer (HNC). Acupuncture-like transcutaneous electrical nerve stimulation (ALTENS) treatment has been studied as an encouraging modality to improve salivary function and related symptoms. The purpose of this study was to compare ALTENS treatment by using a four-times weekly schedule for 6 weeks versus a twice-weekly schedule for 12 weeks with a validated xerostomia scale at 15 months from the start of ALTENS treatment. Materials and Methods: This single-center randomized study was conducted in 30 patients treated with radiotherapy with or without chemotherapy for HNC between 2014 and 2017, who had at least grade 1 or 2 symptomatic dry mouth (xerostomia) according to CTEP NCI Common Terminology Criteria for Adverse Events (CTCAE version 4.0). These patients were randomly assigned to receive ALTENS four-times weekly for 6 weeks or two-times weekly for 12 weeks. The University of Michigan 15-item Xerostomia-related Quality of Life Scale (XeQoLS) was administered at 6, 9, 15, and 21 months from the start of ALTENS treatment. A random-effects generalized linear model was used to model the overall XeQoLS score at the 15-month endpoint; adjusted for a random time effect, a fixed treatment arm, and interaction of time and treatment. Comparison between arms was based on a 0.05 nominal significance level. Results: XeQoLS decreased for all patients (although not statistically for each arm) from a mean of 22 and 21 at baseline (in the four times per week and twice weekly arms) to 12 in both arms at 15 months, with no difference between arms (p = 0.68). There were no attributable grade 1-3 adverse events. Arms were balanced for age, gender, race, and baseline xerostomia. Conclusions: This study demonstrates that both ALTENS regimens are safe, well tolerated, and appear to be equally effective. We now routinely make ALTENS units available for home use.

show abstract

“…After the publication of the previous review, there has been only one additional report of a RCT that compared two different ALTENS protocols without placebo control (Iovoli et al., 2020). In addition, from a previous case report, the authors proposed ALTENS for home use in the future (Iovoli & Singh, 2017). It would be interesting the see the future development of the TENS protocol for managing radiation‐induced dry mouth.…”

Section: Discussionmentioning

confidence: 99%

Non‐pharmacologic interventions for management of radiation‐induced dry mouth: A systematic review

Khamdi,

Matangkasombut,

Lam‐Ubol

2023

Oral Diseases

View full text Add to dashboard Cite

ObjectivesRadiation‐induced dry mouth negatively impacts patients' oral health and quality of life. Currently, evidence‐based recommendation for non‐pharmacologic interventions is still lacking.This study aimed to systematically review clinical trials evaluating the efficacy of non‐pharmacologic interventions in cancer patients with radiation‐induced dry mouth.MethodsRandomized controlled trials from 2000 were searched from 4 databases, including MEDLINE, Cochrane, Embase via OVID, and SCOPUS, up to December 16th, 2022 (PROSPERO registration CRD42022378405). The risk of bias was assessed using the revised Cochrane risk of bias assessment tool.ResultsTwenty‐one studies were included: 11 on artificial saliva, 4 on electrical nerve stimulation (TENS), 2 on acupuncture, and one study each on low‐level laser therapy, stem cells, chewing gum, and probiotics. Overall bias was low, medium, and high in 33%, 48%, and 19% of the studies, respectively. Certain artificial saliva products and TENS were shown to improve dry mouth symptoms and salivary flow rate (SFR). One study showed that stem cell transplantation significantly increased SFR.ConclusionsThe evidence suggested that certain artificial saliva products and TENS are promising management. However, the evidence was still limited due to heterogeneity of interventions and outcome measurements. Thus, future studies using standard measurements and long‐term follow‐up are warranted.

show abstract

Accupuncture-like transcutaneous electrical nerve stimulation therapy success using a commercially available unit 8 years post-radiation for xerostomia: a case report

Cited by 6 publications

References 7 publications

Clinical Study on Electronic Medical Neuroelectric Stimulation Based on the Internet of Things to Treat Epilepsy Patients with Anxiety and Depression

Clinical Study on Electronic Medical Neuroelectric Stimulation Based on the Internet of Things to Treat Epilepsy Patients with Anxiety and Depression

Two- Versus Four-Times Weekly Acupuncture-Like Transcutaneous Electrical Nerve Stimulation for Treatment of Radiation-Induced Xerostomia: A Pilot Study

Non‐pharmacologic interventions for management of radiation‐induced dry mouth: A systematic review

Contact Info

Product

Resources

About