1986
DOI: 10.1016/0304-4165(86)90129-7
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Accumulations of cyclic AMP and inositol phosphates in guinea pig cerebral cortical synaptoneurosomes: enhancement by agents acting at sodium channels

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Cited by 17 publications
(6 citation statements)
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“…In accordance with other studies the use of filtered versus unfiltered synaptoneurosomal preparations gave comparable results (Hollingsworth et al, 1986;Gusovsky and Daly, 1988). The unfiltered preparation of synaptoneurosomes was used in our studies.…”
Section: Synaptoneurosome-enriched Preparation From Rat Brain Cortexsupporting
confidence: 91%
“…In accordance with other studies the use of filtered versus unfiltered synaptoneurosomal preparations gave comparable results (Hollingsworth et al, 1986;Gusovsky and Daly, 1988). The unfiltered preparation of synaptoneurosomes was used in our studies.…”
Section: Synaptoneurosome-enriched Preparation From Rat Brain Cortexsupporting
confidence: 91%
“…Even if all agents known to produce an overall membrane depolarization via Na+ influx, and in particular the Na+ ionophore monensin, stimulate the metabolism of Ips (Gusovsky et al, , 1987Habermann and Laux, 1986;Hollingsworth et al, 1986;Guiramand et al, 19898, 1991), the involvement of Na+ influx as a common step in the mechanism of activation of the phosphoinositide breakdown by Glu and depolarizing agents is unlikely. Indeed, the replacement of external Na' by various compounds provokes a depolarization of the synaptoneurosomal membrane, associated with an increase in accumulation of IPS .…”
Section: The Putative Common Step In the Action Of Glu And Depolarizimentioning
confidence: 99%
“…It is now generally accepted that several cell-surface receptors are linked to phosphoinositidase C and that products of polyphosphoinositide hydrolysis are important intracellular messengers (for review, see Berridge & Irvine, 1989). In addition to the well-documented studies of receptor-mediated phosphoinositide breakdown, it is apparent that depolarization induced by elevated extracellular K+ or veratrine can also stimulate phosphoinositide hydrolysis in several tissues, particularly those of a neuronal nature (Kendall & Nahorski, 1984Bone & Michell, 1985;Baird & Nahorski, 1986, 1989, 1990Court et al, 1986;Eva & Costa, 1986;Hollingsworth et al, 1986;Gusovsky et al, 1986;Habermann & Laux, 1986;Gurwitz & Sokolovsky, 1987;Audigier et al, 1988;Sasaguri & Watson, 1988;McDonough et al, 1988). In several of these studies, indirect effects of depolarization can be eliminated and responses can be shown to be secondary to Ca2l entry via voltage-sensitive channels.…”
Section: Introductionmentioning
confidence: 99%