Accumulation of tissue advanced glycation end products correlated with glucose exposure dose and associated with cardiovascular morbidity in patients on peritoneal dialysis

Jiang, Jianping; Chen, Pingyan; Chen, Jianghua; Yu, Xueqing; Xie, Di; Mei, Changlin; Xiong, Fei; Shi, Wei; Zhou, Wei; Liu, Xusheng; Sun, Shan; Zhang, Ping; Yang, Xiao; Zhang, Yixiang; Zhang, Yanmin; Liang, Xinling; Zhang, Zhimin; Lin, Qian; Yu, Yan; Miyata, Toshio; Tian, Jianwei; Liang, Min; Luo, Weihong; Xu, Xin; Hou, Fanfan

doi:10.1016/j.atherosclerosis.2012.06.022

Cited by 64 publications

(63 citation statements)

References 36 publications

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“…Increased oxidative stress has been linked to accelerated atherosclerosis and CVD in dialysis patients (34)(35)(36). One study found increased levels of asymmetrical dimethylarginine (37), a compound reflecting oxidative stress, in patients who experienced cardiovascular events or who died (14).…”

Section: Discussionmentioning

confidence: 99%

Oxidative Dna Damage and Mortality in Hemodialysis and Peritoneal Dialysis Patients

Watanabe

Qureshi

et al. 2015

Perit Dial Int

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Section: Discussionmentioning

confidence: 99%

Oxidative Dna Damage and Mortality in Hemodialysis and Peritoneal Dialysis Patients

Watanabe

Qureshi

et al. 2015

Perit Dial Int

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“…Several studies support the theory that serum AGEs may not be a good indicator of AGE dependent tissue damage (101)(102)(103).…”

Section: Age Evaluation Methodsmentioning

confidence: 84%

Glycation: Implication in Perceived Age and Dermatology

2014

RoJCED

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Perceived age comprises different facial features and it is associated with multiple external factors, one of which is high levels of serum glucose. Modern Western diet is associated with systemic elevated sugar levels. Excess sugars react with proteins, forming protein-bounded sugars involved in the process named glycation and resulting in the formation of advanced glycation end products or AGEs. This article reviews the pathophysiological mechanisms involved in glycation and AGEs' impact on tissues and organs of both healthy and diabetic individuals. Dietary advice must be an important part of medical consultation, emphasizing the benefi ts of a hypoglycemic diet. Future research aimed at discovering universal molecules that could interfere with AGE's will be a major breakthrough in the management of diabetes and aging related conditions.

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“…Under normal conditions, EPCs grown in the bone marrow are in a state of dormancy; vascular injury, heart failure or myocardial infarction, limb ischemia and hypoxia, or cytokine or drug stimulation induces the migration of EPCs to the lesion, promoting angiogenesis and injury repair in the affected area. Studies have shown that the cells produce an excess of oxidative stress products under high glucose conditions, which is far beyond the elimination and repair capacity of the body (Stadler et al, 2004;Jiang et al, 2012). Excessive accumulation of ROS causes disorders in the normal cell growth cycle, leading to the induction of apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Effect of procyanidine on VEGFR-2 expression and transduction pathway in rat endothelial progenitor cells under high glucose conditions

Y¹,

Wj²,

Zhu³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. The protective effect of procyanidine and its oligomers against high glucose-mediated oxidative stress injury in endothelial progenitor cells (EPCs), and effect of procyanidin on vascular endothelial growth factor receptor-2 (VEGFR-2) expression and downstream signal pathway were analyzed in vitro. Rat bone marrow mononuclear cells were isolated, cultured under normal and high glucose (HG) conditions, and the changes in cell morphology observed. The EPCs were identified, and the oxidative stress products produced by EPCs (under normal and HG conditions) were quantified. Subsequently, an appropriate number of EPCs were cultured with and without procyanidin (OPC), and the MDA concentration and relative expression of VEGFR-2, AKT, IkB-a, and nuclear factor (NF)-kB were detected 1, 3, 5, and 7 days post-culture. We observed minor (round, translucent, gradually adhering) and significant (fusiform morphology/ pebble distribution) cell morphological changes 3 and 7 days post-culture, respectively. Apoptosis and oxidative stress product release in EPCs cultured with HG increased significantly compared to the control group (P < 0.05). The oxidative stress product generation and relative expression of VEGFR-2, AKT, IkB-a, and NF-kB were not significantly affected by OPC addition in normal glucose conditions (P > 0.05); alternately, products generated as a result of oxidative stress were significantly reduced, the relative expression of VEGFR-2, AKT, and NF-kB protein was upregulated, and that of IkB-a was downregulated (P < 0.05) in HG + OPC EPCs. Therefore, procyanidin may promote cell proliferation by alleviating oxidative damage to EPCs under HG conditions, and upregulating VEGFR-2 expression and its downstream signal pathway.

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Accumulation of tissue advanced glycation end products correlated with glucose exposure dose and associated with cardiovascular morbidity in patients on peritoneal dialysis

Cited by 64 publications

References 36 publications

Oxidative Dna Damage and Mortality in Hemodialysis and Peritoneal Dialysis Patients

Oxidative Dna Damage and Mortality in Hemodialysis and Peritoneal Dialysis Patients

Glycation: Implication in Perceived Age and Dermatology

Effect of procyanidine on VEGFR-2 expression and transduction pathway in rat endothelial progenitor cells under high glucose conditions

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