Accumulation of oxidative stress-related gene polymorphisms and the risk of coronary heart disease events in patients with type 2 diabetes – An 8-year prospective study

Katakami, Naoto; Kaneto, Hideaki; Matsuoka, Taka‐aki; Takahara, Mitsuyoshi; Osonoi, Takeshi; Saitou, Miyoko; Kawai, Koichi; Ishibashi, Fukashi; Kashiwagi, Atsunori; Kawamori, Ryuzo; Shimomura, Iichiro; Yamasaki, Yoshimitsu

doi:10.1016/j.atherosclerosis.2014.05.936

Cited by 20 publications

(24 citation statements)

References 40 publications

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“…NADPH oxidase is one of the chief sources of O 2 - in vascular cells, monocytes and neutrophils [83, 86]. The P22phox subunit is its main catalytic subunit [86] with two polymorphisms implicated in CAD pathogenesis, namely C242T (rs4673) and A640G.…”

Section: Gene Polymorphisms Of the Ros Production Systemmentioning

confidence: 99%

“…studies with CAD in T2DM (Table 2 ) were done in two different Asian subsets of patients, and 3 studies [83-85] were conducted on a similar pool of patients by the same author. The results were again contradictory, however, the largest study [85] demonstrated no association.…”

Section: Gene Polymorphisms Of the Ros Production Systemmentioning

confidence: 99%

“…MPO is a member of the heme peroxidase superfamily which produces strong oxidant hypochlorous acid HOCl  and is positioned in lysosomes of monocytes and neutrophil cells [83, 91]. A large study [92] conducted on a mixed population examined rs2107545, Val717Ile and rs2071409 polymorphism association with CAD, confirming rs2107545 and rs2071409 association with with CAD prevalence.…”

Section: Myeloperoxidase (Mpo) Polymorphismsmentioning

confidence: 99%

“…The promoter polymorphism -463 G/A (rs2333227) GG genotype was associated with higher MPO activity and was suggested to be a risk factor for T2DM [91]. A few studies have so far tested a possible association of the MPO rs2333227 polymorphism with CAD in T2DM (Table 2 ) [83-85]. The studies were done on a similar large cohort by the same author who found no association with CAD.…”

Section: Myeloperoxidase (Mpo) Polymorphismsmentioning

confidence: 99%

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Oxidative Stress Genes, Antioxidants and Coronary Artery Disease in Type 2 Diabetes Mellitus

Tibaut¹,

Petrovič

2016

CHAMC

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The worldwide increasing prevalence of obesity and sedentary lifestyle is the main cause of the rising incidence of T2DM. Due to chronic macrovascular and microvascular complications, T2DM represent a huge socioeconomic burden in the world. Oxidative stress is a key pathogenic mechanism implicated in diabetic coronary artery disease (CAD). Polymorphisms of oxidative stress genes are known to influence oxidative stress levels and are therefore thought to impact CAD pathogenesis. Identifying higher risk groups would be rational, since it would allow better sample selection and thus better results in antioxidant trials. In this review, we summarize the evidence of oxidative stress gene polymorphisms related to the pathogenesis of CAD. Moreover, we provide a review of antioxidants tested in subjects with CAD.

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Section: Gene Polymorphisms Of the Ros Production Systemmentioning

confidence: 99%

Section: Gene Polymorphisms Of the Ros Production Systemmentioning

confidence: 99%

Section: Myeloperoxidase (Mpo) Polymorphismsmentioning

confidence: 99%

Section: Myeloperoxidase (Mpo) Polymorphismsmentioning

confidence: 99%

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Oxidative Stress Genes, Antioxidants and Coronary Artery Disease in Type 2 Diabetes Mellitus

Tibaut¹,

Petrovič

2016

CHAMC

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“…The MnSOD Val16Ala polymorphism (rs4880), in exon 2 of the human MnSOD gene located on chromosome 6q25, is considered the most interesting polymorphism in the MnSOD gene because the substitution of the T allele for the C allele could result in reduced MnSOD activity and less-efficient transport of MnSOD into the mitochondrial matrix (Shimoda-Matsubayashi et al 1996; Sutton et al 2003). The MnSOD Val16Ala polymorphism has been shown to be associated with diabetes and diabetic complications, but the findings are inconsistent (Katakami et al 2014; Möllsten et al 2007, 2009; Tian et al 2011). …”

Section: Introductionmentioning

confidence: 99%

U-Shaped Association between Plasma Manganese Levels and Type 2 Diabetes

Shan

Chen

Sun

et al. 2016

Environ Health Perspect

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Background:Manganese is both an essential element and a known toxicant, and it plays important roles in many mechanisms in relation to type 2 diabetes (T2D). However, epidemiological studies of this relationship are rare.Objective:We investigated the association between plasma manganese and newly diagnosed T2D as well as whether the association could be modified by manganese superoxide dismutase (MnSOD) polymorphisms.Methods:We conducted a case–control study of 3,228 participants in China: 1,614 T2D patients and 1,614 controls. Concentrations of plasma magnesium were measured, and all participants were genotyped for the MnSOD Val16Ala polymorphism (rs4880).Results:A U-shaped association was observed between plasma manganese and T2D, with increased odds ratios (ORs) in relation to either low or high plasma manganese levels. Compared with the middle tertile, the multivariate-adjusted ORs [95% confidence intervals (CIs)] of T2D associated with the lowest tertile and the highest tertile of plasma manganese were 1.89 (1.53, 2.33) and 1.56 (1.23, 1.97), respectively. In spline analysis, the U-shaped association was consistently indicated, with the lowest odds of T2D at the plasma manganese concentration of 4.95 μg/L. Minor allele frequencies (C allele) of the MnSOD Val16Ala polymorphism (rs4880) in the normal glucose tolerance (NGT) and the T2D groups were 13.57% and 14.50%, respectively. The MnSOD rs4880 polymorphism was not associated with T2D, and no interaction was found between plasma manganese and the MnSOD rs4880 polymorphism in relation to T2D.Conclusions:Our results suggested a U-shaped association between plasma manganese and T2D; both low and high levels of plasma manganese were associated with higher odds of newly diagnosed T2D. The U-shaped association was not modified by the MnSOD rs4880 polymorphism.Citation:Shan Z, Chen S, Sun T, Luo C, Guo Y, Yu X, Yang W, Hu FB, Liu L. 2016. U-shaped association between plasma manganese levels and type 2 diabetes. Environ Health Perspect 124:1876–1881; http://dx.doi.org/10.1289/EHP176

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