Accumulation of natriuretic peptides is associated with protein energy wasting and activation of browning in white adipose tissue in chronic kidney disease

Luce, Mathilde; Barba, Christophe; Mey, Anne; Roussel, Damien; Bres, Émilie; Benoit, Bérengère; Pastural, Myriam; Granjon, Samuel; Szelag, Jean Christophe; Laville, Maurice; Arkouche, Walid; Bouchara, Anaïs; Nyam, Elsa; Fouque, Denis; Soulage, Christophe O.; Koppe, Laetitia

doi:10.1016/j.kint.2020.03.027

Cited by 19 publications

(18 citation statements)

References 48 publications

(65 reference statements)

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“…As described above, an important trigger of cachexia is the imbalance of anabolic and catabolic processes, especially in adipose tissue. Luce et al 75 attributed CKD‐associated energy wastage to browning activation due to the direct effects of the uremic environment on adipocytes, which was closely associated with the accumulation of NPs in adipose tissue. The authors found increased resting energy expenditure in a CKD mouse model, along with increased levels of ANP and UCP1 expression.…”

Section: Resultsmentioning

confidence: 99%

Regulatory role of atrial natriuretic peptide in brown adipose tissue: A narrative review

Tian

et al. 2022

Obesity Reviews

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Summary Atrial natriuretic peptide (ANP) has been considered to exert an essential role as a cardiac secretory hormone in the regulation of hemodynamic homeostasis. As the research progresses, the role of ANP in the crosstalk between heart and lipid metabolism has become an interesting topic that is attracting the interest of researchers. The regulation of ANP in lipid metabolism shows favorable effects, particularly the activation of brown adipose tissue (BAT). The complex regulatory network of ANP on BAT has not been fully outlined. This narrative review critically evaluated the existing literature on the regulatory effects of ANP on BAT. In general, we have summarized the expression of ANP and its receptors in various human tissues, analyzed the progress of research on the relationship between the ANP and BAT, and described several potential pathways of ANP to BAT. Exogenous ANP, natriuretic peptide receptor C (NPRC) deficiency, cold exposure, bariatric surgery, and cardiac or renal insufficiency could all contribute to BAT expression by increasing circulating ANP levels.

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Section: Resultsmentioning

confidence: 99%

Regulatory role of atrial natriuretic peptide in brown adipose tissue: A narrative review

Tian

et al. 2022

Obesity Reviews

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“…We also showed that fluid accumulation contributed to a loss in fat mass (beta = −0.35, p < 0.0001). The underlying mechanism of such association may potentially be explained by the experiment of Luce et al, who reported that natriuretic peptides activated lipolysis and browning of fat by increasing the synthesis of uncoupling protein 1 in mouse model [ 47 ]. Therefore, fluid overload, which was often accompanied by elevation of natriuretic peptides and hypoalbuminemia, may play a role in pathogenesis of protein energy wasting.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Volume Overload on the Longitudinal Change of Adipose and Lean Tissue Mass in Incident Chinese Peritoneal Dialysis Patients

Chan

Kam

et al. 2022

Nutrients

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Patients treated with peritoneal dialysis (PD) experience complex body composition changes that are not adequately reflected by traditional anthropometric parameters. While lean and adipose tissue mass can be readily assessed by bioimpedance spectroscopy (BIS), there is concern about the potential confounding effect of volume overload on these measurements. This study aimed to assess the influence of fluid status (by echocardiography) on body composition parameters measured by BIS and to describe the longitudinal changes in adipose and lean tissue mass. We conducted a prospective observational study in a tertiary hospital. Incident Chinese PD patients underwent baseline echocardiography and repeated BIS measurements at baseline and 12 months later. Among 101 PD patients, lean tissue index (LTI) or fat tissue index (FTI) was not associated with echocardiographic parameters that reflected left ventricular filling pressure (surrogate of volume status). Sixty-eight patients with repeated BIS had a significant increase in body weight and FTI, while LTI remained similar. Gains in fat mass were significantly associated with muscle wasting (beta = −0.71, p < 0.0001). Moreover, progressive fluid accumulation independently predicted decrease in FTI (beta = −0.35, p < 0.0001) but not LTI. Body composition assessments by BIS were not affected by fluid status and should be considered as part of comprehensive nutrition assessment in PD patients.

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“…Binding of NPs to NPR-A results in generation of cyclic guanosine monophosphate (cGMP) from guanosine triphosphate, which further activates protein kinase G (PKG) and mammalian target of rapamycin (mTOR) targeting cells to perform effect (Fig. 2 A) [ 5 , 112 , 113 ]. This atypical serin/threonine protein kinase, mTOR controls numerous cellular functions related to cell growth and homeostasis including protein synthesis, metabolism, survival, and proliferation [ 114 ].…”

Section: Sacubitril/valsartan (Entresto®) and Browningmentioning

confidence: 99%

Cooling down with Entresto. Can sacubitril/valsartan combination enhance browning more than coldness?

Turnic

Novakovic

Ramenskaya

et al. 2022

Diabetol Metab Syndr

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Background It is a growing importance to induce a new treatment approach to encourage weight loss but also to improve maintenance of lost weight. It has been shown that promotion of brown adipose tissue (BAT) function or acquisition of BAT characteristics in white adipose tissue (terms referred as “browning”) can be protective against obesity. Main text Amongst numerous established environmental influences on BAT activity, cold exposure is the best interested technique due to its not only effects on of BAT depots in proliferation process but also de novo differentiation of precursor cells via β-adrenergic receptor activation. A novel combination drug, sacubitril/valsartan, has been shown to be more efficient in reducing cardiovascular events and heart failure readmission compared to conventional therapy. Also, this combination of drugs increases the postprandial lipid oxidation contributing to energy expenditure, promotes lipolysis in adipocytes and reduces body weight. To date, there is no research examining potential of combined sacubitril/valsartan use to promote browning or mechanisms in the basis of this thermogenic process. Conclusion Due to the pronounced effects of cold and sacubitril/valsartan treatment on function and metabolism of BAT, the primary goal of further research should focused on investigation of the synergistic effects of the sacubitril/valsartan treatment at low temperature environmental conditions.

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Accumulation of natriuretic peptides is associated with protein energy wasting and activation of browning in white adipose tissue in chronic kidney disease

Cited by 19 publications

References 48 publications

Regulatory role of atrial natriuretic peptide in brown adipose tissue: A narrative review

Regulatory role of atrial natriuretic peptide in brown adipose tissue: A narrative review

The Impact of Volume Overload on the Longitudinal Change of Adipose and Lean Tissue Mass in Incident Chinese Peritoneal Dialysis Patients

Cooling down with Entresto. Can sacubitril/valsartan combination enhance browning more than coldness?

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