Accumulation of mixed mineral dusts in the lungs of rats during chronic inhalation exposure

McMillan, C.H.; Jones, A. D.; Johnston, A.M.; Douglas, Analise; Cowie, Hilary

doi:10.1016/s0013-9351(89)80036-2

Cited by 10 publications

(1 citation statement)

References 8 publications

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“…In some chronic inhalation exposures to mixed dusts in rats the conclusion was reached that transfer to the lymph nodes accounted for most of the postexposure clearance for some of the tested dusts (McMillan et al, 1989).…”

Section: Discussionmentioning

confidence: 99%

Pleural Mesothelioma in a Woman Whose Documented Past Exposure to Asbestos was From Smoking Asbestos-Containing Filtered Cigarettes: The Comparative Value of Analytical Transmission Electron Microscopic Analysis of Lung and Lymph-Node Tissue

Dodson

Hammar

2006

Inhalation Toxicology

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Asbestos has had many commercial applications, including its use as a major component in various types of filters. Between 1952 and 1956, crocidolite asbestos was used as a component of filters for cigarettes, reportedly greatly reducing tars and nicotine from mainstream smoke. This case report quantifies asbestos burden in lung and lymph node tissue in a 67-yr-old woman who succumbed to mesothelioma. Her only historically documented exposure to asbestos was from smoking crocidolite asbestos-containing filtered cigarettes between 1952 and 1956. Tissue digestion analysis by analytical transmission electron microscopy (ATEM) identified crocidolite fibers in lungs and thoracic lymph nodes. Combined ATEM data of lung and lymph node tissue clarified the patient's exposure to asbestos and particularly to crocidolite asbestos and thus to the presence of an entity recognized as the causal agent for mesothelioma.

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Section: Discussionmentioning

confidence: 99%