Accumulation of low molecular weight (bleomycin detectable) iron in bone marrow cells of rats after benzene exposure

Pandya, K. P.; Rao, G. Sasibhushana; Khan, Sikandar G.; Krishnamurthy, R.

doi:10.1007/bf01972997

Cited by 15 publications

(5 citation statements)

References 20 publications

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“…Saleh et al ( 2007 ) has been observed an increase in MDA levels (p < 0.01) of albino rats exposed to 0.5 ml/kg body weight benzene but observed a decrease in the levels of SOD and catalase concentration than control group. Benzene administration to albino rats increased their MDA levels in the same way as reported in other studies (Ahmad et al 1994 ; Pandya et al 1990 ). Also, Kumar and Singh ( 2003 ) observed increase in level of MDA and catalase in benzene, toluene and xylene treated rat in comparison to control.…”

Section: Discussionsupporting

confidence: 86%

Haemato-biochemical, mutagenic, and histopathological changes in Oreochromis niloticus exposed to BTX

Sayed

Idriss

Abdel-Ghaffar

et al. 2023

Environ Sci Pollut Res

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The study of the DNA damage response in erythrocytes after exposure to volatile organic compounds (VOCs) can present evidence for its potential effect as genotoxic- biomarkers for environmental pollution. Although VOCs are dangerous pollutants, still little is known about hemotoxic, cytotoxic, and genotoxic effects of such pollutants on fish. We optimized an assay method for apoptosis and DNA damage in erythrocytes of adult tilapia fish after 15 days exposure to benzene (0.762 ng/L), toluene (26.614 ng/L), and xylene (89.403 ng/L). The highest level of apoptosis and DNA damage were recorded in benzene-exposed fish, as was the highest level of histopathological alterations in gills, liver, and kidney. The imbalance of the antioxidants profile explained the stress-case reported in exposed fish. These results suggest that hemotoxic, cytotoxic, genotoxic, and tissue damage were recorded after exposure to BTX in Oreochromis niloticus.

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Section: Discussionsupporting

confidence: 86%

Haemato-biochemical, mutagenic, and histopathological changes in Oreochromis niloticus exposed to BTX

Sayed

Idriss

Abdel-Ghaffar

et al. 2023

Environ Sci Pollut Res

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“…The results showed that MDA level was higher in benzene group (p < 0.01) compared to control group (Figure 1). This confirms the findings of Pandya et al (1990) and Ahmad et al (1994) who reported that benzene administration increased the level of MDA in albino rats. Also, Emara and El-Bahrawy (2008) reported that benzene exposure significantly increased plasma MDA levels and decreased total antioxidant activity.…”

Section: Effect Of Zn and Se On Mda And Scavenging Enzymessupporting

confidence: 92%

Protective effects of zinc and selenium against benzene toxicity in rats

et al. 2011

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The presented study investigates the protective role of zinc (Zn) and selenium (Se) in attenuating benzene-induced toxicity in rats. Male Sprague-Dawley rats were injected with benzene (0.5 mL/kg body weight ip) and received a diet supplement containing Zn and Se. Several hematological and biochemical parameters (representing antioxidant status) were estimated. Histopathological examinations were performed. Results showed that food intake and body weight gain of benzene-injected rats were significantly lower than that of the control rats. Benzene-injected rats showed increased plasma malondialdehyde (MDA) and decreased activity of: glutathione peroxidase (GSH-Px), catalase, superoxide dismutase (SOD) enzymes, as well as reduced glutathione (GSH) when compared to the control group. Histopathological investigations revealed structural changes in benzene-injected rats' liver. Supplementation with Zn and Se resulted in a significant decrease in MDA, elevation in GSH, GSH-Px, SOD and catalase levels. This study shows that Zn and Se supplementation can improve the activity of antioxidant enzymes in rats and decrease the histological anomalies induced by benzene toxicity as well.

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“…Rats injected with benzene showed an increase in MDA levels (p<0.01) accompanied with a decrease in the levels of scavenging enzymes SOD, catalase, glutathione peroxidase (GSH-Px) and GSH concentration than control group (table 5). The data are similar to those from other reports which indicated that benzene administration increased the level of MDA in albino rats (Pandya et al, 1990& Ahmad et al, 1994. Also Chen, (1992) observed that in the workers exposed to benzene the content of serum MDA increased and the activities of erythrocyte SOD and erythrocyte GSH-Px were decreased.…”

Section: Resultssupporting

confidence: 92%