Accumulation of gallium-67 within mature and immature teratoma in pediatric patients: investigation for the uptake mechanism

Abstract

A high-uptake ratio of (67)Ga in benign teratoma was indicated. A close correlation between gallium scan and CT helps to ascertain whether (67)Ga uptake results from malignant and/or immature elements, or mature tissue components.

What recent primary studies tell us about ovarian teratomas in children: a scoping review

“…Obtaining the correct pathology report is of crucial importance in this case. Performing a central pathomorphological examination can be helpful as it was mentioned by some of the studies [2,15,19,20,22,24,26,33].…”

“…A high-uptake ratio of gallium-67 in benign teratoma was indicated in one manuscript. A study by Gu et al revealed that GFAP (glial fibrillary acidic protein) is highly expressed in the nerve tissue of mature teratomas and is low in that of immature ones [33,34].…”

Molecular Imaging in Gynecology: Beyond Cancer

“…In a 2015 study of 26 patients, for example, MRI proved superior to [ 18 F]FDG PET for distinguishing between benign (mature) and malignant (immature) teratomas (45). A previous study with [ 67 Ga]Ga SPECT provided similar results (46). The dense and fibrous nature of Brenner tumors-an ovarian lesion that can be benign or malignant-facilitates ready visualization via MRI, making it the current diagnostic gold standard (47).…”