Accumulation of Fascin+ cells during experimental autoimmune neuritis

Abstract

BackgroundExperimental autoimmune neuritis (EAN) is a well-known animal model of human demyelinating polyneuropathies and is characterized by inflammation and demyelination in the peripheral nervous system. Fascin is an evolutionarily highly conserved cytoskeletal protein of 55 kDa containing two actin binding domains that cross-link filamentous actin to hexagonal bundles.MethodsHere we have studied by immunohistochemistry the spatiotemporal accumulation of Fascin + cells in sciatic nerves of EAN rats.ResultsA robust accumulation of Fascin + cell was observed in the peripheral nervous system of EAN which was correlated with the severity of neurological signs in EAN.ConclusionOur results suggest a pathological role of Fascin in EAN.Virtual slidesThe virtual slides for this article can be found here: http://www.diagnosticphatology.diagnomx.eu/vs/6734593451114811

Intraneural pseudocyst (so-called ganglion) in an unusual retroperitoneal periadnexal location?

“…Although we have not found any evidences of an active inflammatory reaction (like lymphocytes etc.) one cannot exclude that some parts of S-100 immunopositivity may be due to the presence of dendritic cells, which are involved in autoimmune inflammatory processes within the nerve (autoimmune neuritis for instance) [ 17 ]. We may also hypothesize that an autoimmune inflammatory process terminated long ago could have lead to a cyst formation by creating osmotic pressure within the nerve.…”

Roles of Fascin in Dendritic Cells

“…Additionally, fascin is overexpressed in various metastatic tumors and aberrantly expressed in different cancer types, where it is considered a marker and therapeutic target for cancer metastasis [23][24][25]. Fascin expression has been associated with tumor cell migration, invasion, metastasis, and adaptive immune response [24][25][26].…”