Accumulation of DI‐2‐Ethylhexyl Phthalate (DEHP) in Whole Blood, Platelet Concentrates, and Platelet‐Poor Plasma

Contreras, T. J.; Sheibley, R H; Valeri, C. R.

doi:10.1111/j.1537-2995.1974.tb04481.x

Cited by 68 publications

(30 citation statements)

References 24 publications

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“…It is well established that DEHP leaches out of these bags and other medical devices into blood components, that the concentration increases with storage, and that DEHP is converted to MEHP, a more toxic metabolite (1)(2)(3)(4)(5)(6).…”

Section: A Conclusionmentioning

confidence: 99%

“…However, for some time it has been known that the plasticizer di(2-ethylhexyl) phthalate (DEHP), which is added to poly(vinyl chloride) (PVC) plastics to increase flexibility, can leach from the plastic during exposure to blood and blood components (1)(2)(3)(4)(5)(6). PVC plastic is used in a great variety of medical devices, such as tubing for whole blood collection, bags for collection and storage of red cells, platelet concentrates (PC), or plasma, hemodialysis setups, tubing for intravenous injections, cytapheresis, plasma exchange and plasmapheresis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Distribution of Di(2-Ethylhexyl) Phthalate and Products in Blood and Blood Components

Rock¹,

Labow²,

Tocchi³

1986

Environmental Health Perspectives

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In order to impart flexibility, plastic medical devices incorporate liquid plasticizers into their structure. Data from several laboratories, including ours, have shown that these compounds leach from blood bags and tubing during collection of blood, storage of various blood components and during kidney dialysis and cell and plasma apheresis procedures. After the plasticizer di(2-ethylhexyl) phthalate leaches from poly(vinyl chloride) blood packs, it is converted by a plasma enzyme to a more toxic metabolite, mono(2-ethylhexyl) phthalate.Blood fractionation products from outdated plasma contain mono(2-ethylhexyl) phthalate, the highest level being found in normal serum albumin.Recently, we have reported that di(2-ethylhexyl) phthalate actually binds to the red blood cell membrane and reduces its osmotic fragility. Current methods of red cell storage, which permit utilization up to 35 days after collection, are not possible without this membrane stabilization. Platelets are now stored for 5 days in the Fenwal PL 732 polyolefin bag. Although stated to be essentially free of liquid plasticizers, a significant level of leaching from this bag into the extracts of stored platelet concentrates was observed.

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Section: A Conclusionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Distribution of Di(2-Ethylhexyl) Phthalate and Products in Blood and Blood Components

Rock¹,

Labow²,

Tocchi³

1986

Environmental Health Perspectives

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“…Plasticizers were also found in human plasma (372), platelet concentrations (373), and human tissue (374,375).…”

Section: Generalmentioning

confidence: 99%

Priority toxic pollutants in human urine :

Fatiadi¹

1983

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“…Studies have shown that this DEHP leaches into citrate-phosphate-dextrose-adenine (CPDA-1) anticoa gulated whole blood in amounts up to 30 mg/U during the 35-day storage time. The rate of DEHP leaching into platelet concentrates stored 3 days at 22°C with constant agitation is even higher (14.6 mg/U) [1], This material may be hazardous. The report by Jaegar and Rubin [2] demonstrated that these plasticizers do remain in human tissue, and might have some toxic effects.…”

Section: Introductionmentioning

confidence: 99%

Survival of Red Cells Stored for 21 and 35 Days in a Non-Di-(2-Ethylhexyl)Phthalate Plastic Container

Myhre¹,

Johnson²,

Marcus³

et al. 1987

Vox Sanguinis

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Whole blood and red cells were stored using citrate-phosphate-dextrose (CPD) and citrate-phosphatedextrose- adenine (CPDA-1) anticoagulants in polyvinylchloride bags made flexible with di-(2-ethylhexyl)phthalate (DEHP) or tri-(2-ethylhexyl)trimellitate (TOTM) plasticizers. After storage the posttransfusion viability of these cells was tested in autologous donors. Cells stored in TOTM-plasticized film had a survival rate less than 75% when stored for 35 days, while other systems had a survival greater than this. When compared with the red cells stored in CPD-DEHP-plasticized film, the viability of whole blood and red cells stored in CPDA-TOTM showed a statistically significant decrease (p = <0.01). Therefore, red cell storage in TOTM-plasticized PVC with current anticoagulant should be limited to 21 days.

show abstract

Accumulation of DI‐2‐Ethylhexyl Phthalate (DEHP) in Whole Blood, Platelet Concentrates, and Platelet‐Poor Plasma

Cited by 68 publications

References 24 publications

Distribution of Di(2-Ethylhexyl) Phthalate and Products in Blood and Blood Components

Distribution of Di(2-Ethylhexyl) Phthalate and Products in Blood and Blood Components

Priority toxic pollutants in human urine :

Survival of Red Cells Stored for 21 and 35 Days in a Non-Di-(2-Ethylhexyl)Phthalate Plastic Container

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