Accumulation of chlorobiphenyls in chicken fat and liver after feeding Aroclor 1254 directly or fat from swine fed Aroclor 1254

Hansen, Larry G.; Tuinstra, L.G.M.Th.; Kan, C.A.; Strik, Johan J. T. W. A.; Koeman, J.H.

doi:10.1021/jf00116a017

Cited by 21 publications

(6 citation statements)

References 16 publications

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“…The contamination of controls may have resulted from exposure of the birds to contaminated feed dust or fecal material originating from treatment birds housed in adjacent cages. Other studies that have fed PCBs via contaminated pellets to chickens also reported low levels of cross‐contamination of controls, which resulted from exposure to feed dusts [19,20]. In addition, a small amount of [ 12 C]PCB153 was detected in pellet samples of diet 2 (0.0005 ± 0.0003 μg·g −1 ).…”

Section: Resultsmentioning

confidence: 93%

Quantifying maternal and dietary sources of 2,2′,4,4′,5,5′‐hexachlorobiphenyl deposited in eggs of the ring dove (Streptopelia risoria)

Drouillard

Norstrom

2001

Enviro Toxic and Chemistry

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The influence of maternal versus dietary sources of polychlorinated biphenyls (PCBs) deposited to eggs of ring doves (Streptopelia risoria) was investigated. Mature birds that lay a clutch of two eggs every 12 to 15 d were fed a diet of pellets spiked with 2,2',4,4',5,5'-hexacholorobiphenyl (unlabelled isotope designated as [12C]PCB153) for 25 d. The birds were subsequently switched to a diet containing isotopically labeled [U-13C12]PCB153 at similar concentrations for an additional 63 d. The toxicokinetics of [12C]PCB153 and [13C]PCB153 were followed in egg and carcass samples with time. Isotopic ratios of PCB153 in yolk lipids were identical to those in carcass lipids after introduction of diet 2, and they did not resemble those of the food at the time of egg formation. The data indicate that the PCB composition of eggs directly reflects the composition of maternal tissues, not the diet, at the time of yolk formation. Egg yolk:carcass lipid concentration ratios for the two isotopes were significantly less than one, averaging 0.33+/-0.02 (mean +/- standard error). Lipid normalized egg:maternal tissue contaminant concentration ratios for persistent organochlorine chemicals in the literature were reviewed for other avian species. The results provide a preliminary data set that suggests egg:maternal tissue contaminant concentration ratios vary among species, particularly among species that invest different quantities of lipids to a clutch of eggs. The results support the hypothesis that dilution of contaminants in egg lipids relative to maternal lipids is related to the reproductive strategy employed by the species.

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Section: Resultsmentioning

confidence: 93%

Quantifying maternal and dietary sources of 2,2′,4,4′,5,5′‐hexachlorobiphenyl deposited in eggs of the ring dove (Streptopelia risoria)

Drouillard

Norstrom

2001

Enviro Toxic and Chemistry

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“…The uptake from the surrounding water into fish was studied by Broyles & Noveck (1979) who found a 1000-fold bioconcentration. Swine accumulated 6-CB in adipose tissue in a dose-related manner (Hansen et al 1981), and the lard of these animals fed to chickens resulted in 6-CB accumulation in the adipose tissue of the latter species (Hansen et al 1983). Toxicokinetics of 6-CB in mice (Morales et al 1979) and monkeys (Sipes et a/.…”

Section: Resistance To Metabolismmentioning

confidence: 99%

The Use of 2,4,5,2′,4′,5′‐Hexachlorobiphenyl (6‐CB) as an Unmetabolizable Lipophilic Model Compound

Mühlebach¹,

Wyss²,

Bickel³

1991

Pharmacology & Toxicology

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2,4,5,2',4'5'-Hexachlorobiphenyl (6-CB)--a polychlorinated biphenyl (PCB) congener resistant to metabolism in most species--has become a major residue in the biosphere including human adipose tissue. Its use as a model of unmetabolizable lipophilic compounds and as a tool in toxicokinetics in the last two decades is reviewed. This extremely water-insoluble compound is transported in plasma by albumin and lipoproteins. Binding to these plasma proteins appears to be important for uptake and release processes in different tissues. The redistribution kinetics of 6-CB as well as its pronounced adipose tissue storage and a very slow excretion with the faeces has been established in long-term animal studies. Excretion is strongly influenced by an increasing or diminishing adipose storage compartment size. Other minor pathways of elimination, e.g., via hair, become also important in the absence of metabolism and renal excretion. 6-CB has revealed the possibility of an almost quantitative transfer of the maternal body burden to the offspring via milk. The use of 6-CB in studies with tissue preparations in vitro is providing insight into transport mechanisms of uptake and release.

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“…Retention of PCBs is highly species specific: nonhuman primates, for example, retained PCBs more efficiently than rodents (EPA 1980). PCB patterns, especially in warm-blooded animals, only vaguely resemble the mixture from which they originated (Hansen et al . 1983;Ernst 1984).…”

Section: Apiroliomentioning

confidence: 99%

Polychlorinated biphenyl hazards to fish, wildlife, and invertebrates : a synoptic review

Eisler¹

1986

161

146

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Accumulation of chlorobiphenyls in chicken fat and liver after feeding Aroclor 1254 directly or fat from swine fed Aroclor 1254

Cited by 21 publications

References 16 publications

Quantifying maternal and dietary sources of 2,2′,4,4′,5,5′‐hexachlorobiphenyl deposited in eggs of the ring dove (Streptopelia risoria)

Quantifying maternal and dietary sources of 2,2′,4,4′,5,5′‐hexachlorobiphenyl deposited in eggs of the ring dove (Streptopelia risoria)

The Use of 2,4,5,2′,4′,5′‐Hexachlorobiphenyl (6‐CB) as an Unmetabolizable Lipophilic Model Compound

Polychlorinated biphenyl hazards to fish, wildlife, and invertebrates : a synoptic review

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