Accumulation of calcium and phosphate stimulated by carboxylic antibiotics into mitochondria

Estrada-O, Sergio; Céspedes, Carlos de; E, Calderón

doi:10.1007/bf01516075

Cited by 6 publications

(3 citation statements)

References 31 publications

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“…32 For monensin and nigericin, ionotropy results from catecholamine release. 6,25 Monensin causes the translocation of atrial secretory granules, although it has no effect on the granule secretory process. 12 This process is independent of calcium concentration because calcium depletion does not affect secretory granule translocation.…”

Section: Discussionmentioning

confidence: 99%

Toxicosis in Cattle from Concurrent Feeding of Monensin and Dried Distiller's Grains Contaminated with Macrolide Antibiotics

et al. 1999

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Consumption of monensin-containing feed contaminated with macrolide antibiotic residues resulted in the death of cattle from multiple feedlots in south-central Kansas. Cattle were fed milo dried distiller's grains (DDG) with solubles from a common source in conjunction with the ionophore antibiotic, monensin. Deaths occurred as early as 72-96 hours after feeding and were preceded by either no premonitory signs or 1 or more of the following: anorexia, depression, dyspnea, locomotor deficits, and recumbency. Significant gross lesions were pulmonary and mesenteric edema, hepatomegaly, and generalized myocardial and skeletal muscle pallor that was confirmed histologically as acute myodegeneration and necrosis. Other significant histologic lesions included centrolobular hepatocellular necrosis, congestion, and pulmonary interstitial and alveolar edema with fibrin exudation. Animals that survived beyond 6 weeks had poor weight gain and coalescing foci of myocardial fibrosis with residual myocardial degeneration. Analysis of trace mineral supplements for monensin were within the manufacturer's label range. The DDG samples from affected feedlots had 50-1,500 ppm of erythromycin, clarithromycin, and related macrolide antibiotic analogues, which originated in the alcohol residue. In a preliminary feeding trial, cattle fed this contaminated DDG in combination with monensin had clinical signs and died with gross and histologic findings comparable to those of the field cases. Even though rations supplemented with the contaminated DDG contained approved levels of monensin, the clinical and postmortem findings were consistent with those expected for monensin toxicosis. The presence of macrolide antibiotic residues in the contaminated feed appeared to affect the biotransformation of otherwise nontoxic levels of monensin, leading to clinical ionophore toxicosis.

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Section: Discussionmentioning

confidence: 99%

Toxicosis in Cattle from Concurrent Feeding of Monensin and Dried Distiller's Grains Contaminated with Macrolide Antibiotics

et al. 1999

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“…Alkali ion transport across membranes by the enniatin ionophores has been studied much less extensively than that of valinomycin [24,[29][30][31][32]361.…”

Section: Enniatinsmentioning

confidence: 99%

Second febs—ferdinand springer lecture membrane active complexones. chemistry and biological function

Ovchinnikov

1974

FEBS Letters

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“…An alternative to the passive interchange between internal K+ and external safranine is to use nigericin to mobilize the K+ in respiring mitochondria, effectively translating the self-limiting energized safranine-proton exchange into an active interchange between safranine and K+. This has been illustrated for Ca2+ uptake (Estrada-O. et al, 1972;Harris, 1978), and Fig.…”

Section: Safranine Uptake and K+ Movementmentioning

confidence: 73%

Uptake of safranine by cardiac mitochondria. Competition with calcium ions and dependence on anions

Harris¹,

Baum²

1980

Biochemical Journal

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Some characteristics of the energized uptake of safranine by rat heart mitochondria were studied. When monitored by changes in differential absorbance (between 524 and 554 nm) of a whole suspension in safranine-containing medium, the changes seen are not linearly related to the quantity of the safranine moving. It happens coincidentally that the changes observed are nearly linearly related to the logarithm of the ratio between the accumulated safranine and its residual concentration in the medium; this explains why the changes of absorbance have been found by other authors to be linearly related to the logarithms of the ratio of internal/external concentrations of such other cations as are permeable. The uptake process appears to compete for energy with Ca2+ uptake and vice versa. Energized safranine uptake has an anion requirement, which is seen when movement of endogenous Pi has been inhibited; the small residual safranine uptake obtained when energy is provided in the presence of mersalyl may be attributable to internal Pi. However, a limited anion-independent energized uptake of safranine, in exchange for internal K+, may be elicited in the presence of nigericin. Adding ATP to the energized system in the presence of an inhibitor of Pi movement elicits an additional uptake of safranine that is oligomycin-sensitive and that probably arises on account of generation of internal Pi by hydrolysis of the entering ATP.

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Accumulation of calcium and phosphate stimulated by carboxylic antibiotics into mitochondria

Cited by 6 publications

References 31 publications

Toxicosis in Cattle from Concurrent Feeding of Monensin and Dried Distiller's Grains Contaminated with Macrolide Antibiotics

Toxicosis in Cattle from Concurrent Feeding of Monensin and Dried Distiller's Grains Contaminated with Macrolide Antibiotics

Second febs—ferdinand springer lecture membrane active complexones. chemistry and biological function

Uptake of safranine by cardiac mitochondria. Competition with calcium ions and dependence on anions

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