Accumulation of arginine-rich cell-penetrating peptides in tumors and the potential for anticancer drug delivery in vivo

Nakase, Ikuhiko; Konishi, Yusuke; Ueda, Masashi; Saji, Hideo; Futaki, Shiroh

doi:10.1016/j.jconrel.2012.01.016

Cited by 136 publications

(118 citation statements)

References 46 publications

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“…The current researches on the relationship between arginine and growth of xenografted tumor have no unified conclusion with the observation for phenomenon (Wu et al, 2014). Some researches indicate that arginine has antitumor effect, while others think arginine could promote tumor growth; and if the antitumor effect exists, the mechanism is still inconclusive (Nakase et al, 2012).…”

Section: Introductionmentioning

confidence: 94%

Effects of intravenous arginine on the healing of human skin graft donor sites: A randomized controlled trial

Lin

et al. 2015

Bangladesh J Pharmacol

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We expounded the effect of intravenous arginine on the healing of human skin graft donor sites. This randomized study was double blind and controlled by placebos from October 2012 to May 2015. Nine patients were selected into the arginine group and 10 were selected into the control group. There was no significance in age, weight, BMI, CRP, albumin and total plasma protein in arginine and control groups. Angiogenesis, re-epithelialization and neutrophil influx of wound healing were measured. The concentrations of plasma amino acid were measured to evaluate our intervention. In our study, plasma arginine and ornithine concentrations in arginine group were the highest after arginine-treated at 2 days. Supplementation of intravenous arginine could not affect on healing of human skin graft donor sites, improve angiogenesis, reepithelialization or neutrophil influx in rats. Article Info

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Section: Introductionmentioning

confidence: 94%

Effects of intravenous arginine on the healing of human skin graft donor sites: A randomized controlled trial

Lin

et al. 2015

Bangladesh J Pharmacol

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“…The conjugation with CPP's can be used to deliver bioactive molecules, including proteins, nucleic acids, and nanoparticles, into cells. That is why CPP's are promising vehicles for intracellular delivery [54]. Also, a recent study reported that lunasin inhibited colony formation by isolated melanoma of a small population of Cancer-Initiating Cells (CICs) in soft agar and reduced oncosphere formation in vitro and substantially inhibited tumor growth in mouse xenografts.…”

Section: Peasmentioning

confidence: 99%

Bioactive Peptides from Legumes as Anticancer Therapeutic Agents

González-Montoya¹

2017

Int J Cancer Clin Res

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Food proteins are a source of nutraceutical and bioactive peptides that promote health and prevent diseases. Legume seed proteins have been widely studied to produce peptides (protein fragments) with a diversity of biological activities. Generally, these Bioactive Peptides (BPs) are encrypted in proteins but can be released by modifications or cleavage from original protein by means of enzymes during gastrointestinal transit or processes as fermentation, germination, heating and pressure. Storage proteins, lectins and protease inhibitors have been reported to be sources of BPs. These peptides are capable of generating a physiological effect against cancer cells and can induce cell death by different mechanisms like apoptosis, affecting the tubulin-microtubule equilibrium and inhibiting angiogenesis. Finally, anticancer therapy based on legume-derived peptides could play a significant role in the pharmaceutical and nutraceutical industry due to the benefits as functional ingredients which improve the life quality of patients or reduce the risk of cancer.

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“…Fortunately, significant research efforts have been directed towards targeting cancer drugs to tumors using specialized drug carriers, and peptides have become an important component of these targeting approaches 3,90 .…”

Section: Peptides As Anticancer Drug Targeting Carriersmentioning

confidence: 99%

“…In addition, advances in peptide manufacturing have reduced the cost of manufacturing peptides and have enabled small companies to participate in the development of peptides that can be used as therapeutic drugs, the substrates of disease sitespecific stimuli, such as protease and/or structural components of nano-sized carriers that can bind to specific targets with high affinity and can facilitate cellular delivery of cargoes such as cytotoxic drugs and imaging agents 3,89,90 .…”

Section: Peptides As Anticancer Drug Targeting Carriersmentioning

confidence: 99%

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IJPSR

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Accumulation of arginine-rich cell-penetrating peptides in tumors and the potential for anticancer drug delivery in vivo

Cited by 136 publications

References 46 publications

Effects of intravenous arginine on the healing of human skin graft donor sites: A randomized controlled trial

Effects of intravenous arginine on the healing of human skin graft donor sites: A randomized controlled trial

Bioactive Peptides from Legumes as Anticancer Therapeutic Agents

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