Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure

Leone, Anna; Moncada, Salvador; Vallance, Patrick; Calver, Alison; Collier, Joe

doi:10.1016/0140-6736(92)90865-z

Cited by 1,887 publications

(384 citation statements)

References 24 publications

Supporting

Mentioning

373

Contrasting

Unclassified

Order By: Relevance

“…The roles of methionine, homocysteine and arginine in metabolism of asymmetric dimethylarginine. Met-methionine,synthase (NOS) [4]. It originates from L-arginine (Arg) present in body proteins and may undergo hydrolysis to L-citruline and dimethylamine with involvement of dimethylaminohydrolase (DDAH).…”

Section: Introductionmentioning

confidence: 99%

Homocysteine and asymmetric dimethylarginine concentrations in the plasma of Alzheimer’s disease patients with varying degrees of dementia

Dorszewska¹,

Florczak-Wyspiańska²,

Oczkowska³

et al. 2013

AAD

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Homocysteine and asymmetric dimethylarginine concentrations in the plasma of Alzheimer’s disease patients with varying degrees of dementia

Dorszewska¹,

Florczak-Wyspiańska²,

Oczkowska³

et al. 2013

AAD

View full text Add to dashboard Cite

show abstract

“…Pada kondisi yang mengalami perlemakan dan menilai ekspresi ADMA patologis, kadar ADMA meningkat di jaringan sehingga hepar. Data perlemakan dan ekspresi ADMA hepar diolah ADMA bisa dijadikan marker penyakit seperti kondisi dan dianalisis melalui uji homogenitas variances, one way perlemakan hepar (3,4).…”

Section: Amerika Pada Tahun 2006 Membuktikan Secara In Vitrounclassified

Ekstrak Rosela Menurunkan Perlemakan dan Ekspresi ADMA Hepar akibat Diet Aterogenik pada Tikus

Fathoni

Indra

Supranowo

2014

JKB

View full text Add to dashboard Cite

ABSTRAKRosela memiliki anthocyanin sebagai antioksidan polifenol yang berpotensi mencegah progresivitas penyakit akibat stres oksidasi. Diet aterogenik dan stres oksidasi memicu serangan radikal bebas pada komponen lemak dan protein sehingga terjadi perlemakan hepar dan peningkatan ekspresi ADMA (Asymmetric dimethylarginine). Penelitian ini bertujuan mengetahui pengaruh pemberian ekstrak rosela strain Hibiscus sabdariffa terhadap perlemakan hepar dan ekspresi ADMA hepar pada tikus Rattus norvegicus yang diberi diet aterogenik. Studi eksperimental menggunakan post test only control group pada Rattus norvegicus strain Wistar jantan yang dibagi dalam empat kelompok, yaitu kelompok kontrol positif (diet aterogenik), kelompok1 (ekstrak rosela 150mg/kgBB/hari + diet aterogenik), kelompok 2 (ekstrak rosela 300mg/kgBB/hari + diet aterogenik), dan kelompok kontrol negatif (tanpa pemberian diet aterogenik dan ekstrak rosela). Hasil penelitian menunjukkan bahwa ekstrak rosela mampu menurunkan perlemakan hepar yang berdasar pemeriksaan histopatologi berupa jumlah sel yang mengalami perlemakan lebih sedikit (p=0,000). Ekspresi ADMA dari gambaran imunohistokimia menunjukkan ekspresi yang lebih sedikit pada kelompok dengan diberi ekstrak rosela (p=0,000). Dapat disimpulkan pemberian ekstrak rosela menghambat perlemakan hepar akibat diet aterogenik dan ekspresi ADMA akibat diet aterogenik pada tikus, dengan dosis optimum rosela 300 mg/kgBB/hari.

show abstract

“…Clinical and experimental evidence suggest that the elevation of ADMA may cause a low production of NO (11,(14)(15)(16)(17)29,30). Synthesis of NO can be blocked by inhibition of nitric oxide synthase (NOS) activities with guanidino-substituted analogues of L-arginine such as ADMA (28).…”

mentioning

confidence: 99%

“…Nitric oxide also plays a role in regulating renal sodium excretion and renin release (30). Nitric oxide, synthesised from Larginine, contributes to the regulation of blood pressure and to host defence (29). As an endogenous vasodilator it contributes to renal arteriolar tone and modulates relaxation of the mesangium, thus contributing to regulation of glomerular microcirculation.…”

mentioning

confidence: 99%

“…Synthesis of NO can be blocked by inhibition of nitric oxide synthase (NOS) activities with guanidino-substituted analogues of L-arginine such as ADMA (28). Accumulation of endogenous ADMA, leading to impaired NO synthesis, might contribute to the hypertension and immune dysfunction associated with chronic renal failure (29). Reduced bioavailability of NO, increased systemic blood pressure, endothelial cell injury and dysfunction are thought to play an important role in progressive kidney damage (7).…”

mentioning

confidence: 99%

See 1 more Smart Citation

The Effects of Asymmetric Dimethylarginine (ADMA), Nitric Oxide (NO) and Homocysteine (Hcy) on Progression of Mild Chronic Kidney Disease (CKD): Relationship Between Clinical and Biochemical Parameters

Atamer¹,

Ecder²,

Atamer³

et al. 2012

Chronic Kidney Disease

View full text Add to dashboard Cite

Chronic Kidney Disease 198 and plasma synthesized from endothelial cells (Figure 1). It is shown that high ADMA level increases the cardiovascular incident risk by 34% and mortality risk by 52% (4-8). Increased ADMA concentration has a high prevalence in hyperhomocysteinemia, coronary artery diseases, hypercholesterolemia, diabetes mellitus, hypertension, preeclampsia, peripheral arterial occlusive disease, impaired renal function and other diseases (7,9,10). Reduced nitric oxide (NO)-dependent vasodilation is regarded as an early indicator of atherosclerotic diseases (7,14). It is documented that adult patients with renal failure have 2-6 times higher ADMA than healthy subjects due to reduced renal excretion and reduced enzymatic degradation (15). NO is synthesized from L-arginine via NO synthase enzyme. NO inhibition decreases endothelial derived vasodilation and increases vascular resistance. Reduced NO availability can occur in patients with CKD. Moreover CKD can contribute to the accelaration of hypertension and cardiovascular complications. It appears that the increase in endogenic NO inhibitors like ADMA plays a major role in this process (11,(15)(16)(17). It has been shown that Hcy stimulates ADMA formation and plasma ADMA levels elevate in humans and animals by hyperhomocysteinemia (18)(19)(20). Increased serum Hcy level in adult CKD patients is an independent risk factor for cardiovascular system mortality. Elevated ADMA and hyperhomocysteinemia may be due to decreased renal excretion (18)(19)(20)(21)(22). It is reported that ADMA formation may be related with Hcy metabolism (18,19). It was found that there is a significant interaction of serum fibrinogen and CKD with respect to risk of both fatal/nonfatal coronary events and death (20-24).

show abstract

Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure

Cited by 1,887 publications

References 24 publications

Homocysteine and asymmetric dimethylarginine concentrations in the plasma of Alzheimer’s disease patients with varying degrees of dementia

Homocysteine and asymmetric dimethylarginine concentrations in the plasma of Alzheimer’s disease patients with varying degrees of dementia

Ekstrak Rosela Menurunkan Perlemakan dan Ekspresi ADMA Hepar akibat Diet Aterogenik pada Tikus

The Effects of Asymmetric Dimethylarginine (ADMA), Nitric Oxide (NO) and Homocysteine (Hcy) on Progression of Mild Chronic Kidney Disease (CKD): Relationship Between Clinical and Biochemical Parameters

Contact Info

Product

Resources

About