Accumulation of 2,3,7,8‐tetrachlorodibenzo‐<i>p</i>‐dioxin by rainbow trout (<i>Onchorhynchus mykiss</i>) at environmentally relevant dietary concentrations

Jones, Paul D.; Kannan, Kurunthachalam; Newsted, John I.; Tillitt, Donald E.; Williams, Lisa L.; Giesy, John P.

doi:10.1002/etc.5620200215

Cited by 26 publications

(1 citation statement)

References 27 publications

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“…Effects of chronic, sublethal TCDD exposure on reproductive success of fish are a growing concern. While this has not been studied extensively, some studies suggest that sublethal exposure to TCDD impairs gonad development, ovulation and survival of offspring (recruitment) (Giesy et al, 2002; Jones et al, 2001; Tietge et al, 1998; Walker et al, 1994; Walter et al, 2000). …”

Section: Tcdd Toxicity In Adult and Juvenile Feral Fishmentioning

confidence: 99%

Reproductive and developmental toxicity of dioxin in fish

King‐Heiden

Mehta

Xiong

et al. 2012

Molecular and Cellular Endocrinology

145

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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD or dioxin) is a global environmental contaminant and the prototypical ligand for investigating aryl hydrocarbon receptor (AHR)-mediated toxicity. Environmental exposure to TCDD results in developmental and reproductive toxicity in fish, birds and mammals. To resolve the ecotoxicological relevance and human health risks posed by exposure to dioxin-like AHR agonists, a vertebrate model is needed that allows for toxicity studies at various levels of biological organization, assesses adverse reproductive and developmental effects and establishes appropriate integrative correlations between different levels of effects. Here we describe the reproductive and developmental toxicity of TCDD in feral fish species and summarize how using the zebrafish model to investigate TCDD toxicity has enabled us to characterize the AHR signaling in fish and to better understand how dioxin-like chemicals induce toxicity. We propose that such studies can be used to predict the risks that AHR ligands pose to feral fish populations and provide a platform for integrating risk assessments for both ecologically relevant organisms and humans.

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Section: Tcdd Toxicity In Adult and Juvenile Feral Fishmentioning

confidence: 99%

Reproductive and developmental toxicity of dioxin in fish

King‐Heiden

Mehta

Xiong

et al. 2012

Molecular and Cellular Endocrinology

145

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Use of tissue and sediment‐based threshold concentrations of polychlorinated biphenyls (PCBs) to protect juvenile salmonids listed under the US Endangered Species Act

Meador

Collier

Stein

2002

Aquatic Conservation

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Under the Endangered Species Act, the National Marine Fisheries Service has authority to protect listed species from any adverse actions that may jeopardize the population's ability to recover and increase to sustainable levels. Listed salmon species in the northwest United States are known to travel through urban areas in their migration from river to ocean. Species such as the chinook salmon (Oncorhynchus tshawytscha) often spend several weeks in these urban estuaries where they can be highly exposed to urban‐related contaminants that reside in the sediments and accumulate in their prey species. The concern is that these contaminants are bioaccumulated to levels that may impact the ability of individual salmon to grow and mature normally. This paper provides a framework for determining the tissue and sediment concentrations of polychlorinated biphenyls (PCBs) that are likely protective against adverse effects in listed salmonid species. The relevant ecotoxicological literature was examined and 15 studies were selected that met the pre‐established criteria outlined here. For each study, the lowest tissue concentration (residue) of total PCBs associated with a biological response was selected. The tissue concentration associated with the 10th percentile of these 15 studies was chosen to represent the residue effect threshold (RET) above which wild juvenile salmonids would be expected to exhibit adverse sublethal effects from accumulated PCBs. This value (2.4 μg PCBs g−1 lipid) is expressed in terms of the lipid‐normalized concentration because of the large effect lipid can have on the expressed toxicity and the substantial variability in lipid content observed in salmonids over their life cycle. A sediment concentration that is expected to produce the RET was then determined using the biota‐sediment accumulation factor approach. The sediment effect threshold, which varies with the total organic carbon content in sediment, is the level above which adverse effects may be expected in juvenile salmonids due to accumulation of PCBs from environmental exposure. Bioaccumulation of PCBs was examined in one river system as a model for determining an appropriate bioaccumulation factor for wild juvenile chinook salmon. Evaluation of exposure to potentially deleterious concentrations of PCBs based on tissue residues is the preferred approach; however, the sediment effect threshold may also be used in cases where bioaccumulation has been characterized in an estuary. The threshold values presented here are intended as interim guidelines that should be modified as more data become available. Additionally, because of the uncertainty around many of the factors and assumptions that comprise the single threshold effect values, it is recommended that future studies be employed to help determine a range of acceptable values that would afford protection under various environmental and biological conditions. Published in 2002 by John Wiley & Sons, Ltd.

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Retention and maternal transfer of environmentally relevant polybrominated dibenzo‐p‐dioxins and dibenzofurans, polychlorinated dibenzo‐p‐dioxins and dibenzofurans, and polychlorinated biphenyls in zebrafish (Danio rerio) after dietary exposure

Arnoldsson

Haldén

Norrgren

et al. 2012

Enviro Toxic and Chemistry

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High levels of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), mono- and non-ortho-polychlorinated biphenyls (PCBs), and polybrominated dibenzo-p-dioxins (PBDDs) are found in fish from coastal areas in the Baltic Sea, which may cause ecotoxicological effects. To increase our understanding of the persistency of the emerging pollutants polybrominated dibenzo-p-dioxins and dibenzofurans (PBDD/Fs), fish feed was spiked with 21 PBDD/Fs, 17 PCDD/Fs, and 30 PCBs and fed to zebrafish (Danio rerio). Concentrations in fish and eggs were examined during a 6- or 12-week uptake period, and a 6-week elimination period. Steady-state was reached for 2-, 3-, 7-, and/or 8-substituted tri- and tetra-BDD/Fs; 2,3,7,8-tetra-BDD (2,3,7,8-TeBDD) was the most strongly retained. Steady-state was not reached for tetra- to hexa-CDDs. Non-2,3,7,8 congeners showed little or no retention. Most PCBs had high retention and did not reach steady state. Half-lives decreased in the order PCBs > PCDD/Fs > PBDD/Fs. Concentrations of 2,3,7,8-substituted penta- to octa-CDD/Fs decreased with their degree of chlorination, suggesting that the rate-limiting factor for uptake is low bioavailability. Maternal transfer was observed for all retained compounds, with most transfer factors <1, indicating that transfer rates are affected by the poor water solubility of the compounds. The limited retention of the major PBDD congeners found in Baltic Sea fish suggests that they are exposed to high or very high concentrations via either food or water.

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Accumulation of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin by rainbow trout (Onchorhynchus mykiss) at environmentally relevant dietary concentrations

Cited by 26 publications

References 27 publications

Reproductive and developmental toxicity of dioxin in fish

Reproductive and developmental toxicity of dioxin in fish

Use of tissue and sediment‐based threshold concentrations of polychlorinated biphenyls (PCBs) to protect juvenile salmonids listed under the US Endangered Species Act

Retention and maternal transfer of environmentally relevant polybrominated dibenzo‐p‐dioxins and dibenzofurans, polychlorinated dibenzo‐p‐dioxins and dibenzofurans, and polychlorinated biphenyls in zebrafish (Danio rerio) after dietary exposure

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