Accumulation of 19 environmental phenolic and xenobiotic heterocyclic aromatic compounds in human adipose tissue

Wang, Lei; Asimakopoulos, Alexandros G.; Kannan, Kurunthachalam

doi:10.1016/j.envint.2015.02.015

Cited by 167 publications

(88 citation statements)

References 42 publications

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“…However, this is the only study that has been done and published so far concerning the BPA measurement in human hair in order to estimate a chronic and long-term exposure to it. The log K ow value for BPA is 3.64, which suggests the potential BPA bioaccumulation in lipophilic tissues (Wang et al, 2015a). Due to the complexity of the matrix and to the obstacles to obtain the samples, only few studies have demonstrated the high frequency of the BPA detection in adipose tissue in relevant concentration levels of up to 20.9 ng/g so far (Fernandez et al, 2007;Wang et al, 2015aWang et al, , 2015b.…”

Section: Introductionmentioning

confidence: 99%

Estimation of in vivo and in vitro exposure to bisphenol A as food contaminant

Milić

Četojević-Simin

Milanović

et al. 2015

Food and Chemical Toxicology

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Section: Introductionmentioning

confidence: 99%

Estimation of in vivo and in vitro exposure to bisphenol A as food contaminant

Milić

Četojević-Simin

Milanović

et al. 2015

Food and Chemical Toxicology

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“…Due to its lipophilicity, TCS can easily pass through biological barriers and can be accumulated in living organisms [6,8]. A number of studies have revealed the presence of TCS in human tissues, such as in fat, the liver, brain and also in blood or breast milk [9][10][11][12]. Alarming concentrations of TCS have been detected in fish (13-88 ng/g) and human (0.23 ng/g) brains [10,13].…”

Section: Introductionmentioning

confidence: 99%

Triclosan-Evoked Neurotoxicity Involves NMDAR Subunits with the Specific Role of GluN2A in Caspase-3-Dependent Apoptosis

et al. 2018

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Triclosan (TCS) is an antimicrobial agent that is used extensively in personal care and in sanitising products. A number of studies have shown the presence of TCS in different human tissues such as blood, adipose tissue, the liver, brain as well as in breast milk and urine. N-Methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels that are widely expressed in the central nervous system and which play key roles in excitatory synaptic transmission. There is, however, no data on the involvement of NMDAR subunits in the apoptotic and neurotoxic effects of TCS. Our experiments are the first to show that TCS used at environmentally relevant concentrations evoked NMDA-dependent effects in neocortical neurons in primary cultures, as MK-801, an uncompetitive NMDA receptor antagonist, reduced the levels of TCS-induced ROS production as well as caspase-3 activity and LDH release. TCS caused a decrease in protein expression of all the studied NMDA receptor subunits (GluN1, GluN2A, GluN2B) that were measured at 3, 6 and 24 h post-treatment. However, at 48 h of the experiment, the level of the GluN1 subunit returned to the control level, and the levels of the other subunits showed a tendency to increase. In TCS-treated neocortical cells, protein profiles of NMDAR subunits measured up to 24 h were similar to mRNA expression of GluN1 and GluN2A, but not to GluN2B mRNA. In this study, cells transiently transfected with GluN1, GluN2A or GluN2B siRNA exhibited reduced levels of LDH release, which suggests the involvement of all of the studied NMDAR subunits in the neurotoxic action of TCS. According to our data, GluN1 and GluN2A were mainly responsible for neuronal cell death as evidenced by neutral red uptake, whereas GluN2A was involved in TCS-induced caspase-3-dependent apoptosis. We suggest that TCS-evoked apoptosis and neurotoxicity could be related to transient degradation of NMDAR subunits in mouse neurons. Furthermore, recycling of NMDAR subunits in response to TCS is possible. Because transfections with specific siRNA did not completely abolish the effects of TCS as compared to cells transfected with negative siRNA in this study, other NMDAR-independent mechanisms of TCS action are also possible.

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“…24 Recently, we reported an elevated accumulation of parabens and their metabolites in marine mammals, fish, and birds. 25,26 These studies provide insight into the bioaccumulation potential of parabens.…”

Section: ■ Introductionmentioning

confidence: 99%

Trophic Magnification of Parabens and Their Metabolites in a Subtropical Marine Food Web

Xue

Liu

et al. 2017

Environ. Sci. Technol.

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Despite the widespread use of parabens in a range of consumer products, little is known about bioaccumulation of these chemicals in aquatic environments. In this study, six parabens and four of their common metabolites were measured in abiotic (water, sediment) and biotic (fish including sharks, invertebrates, plants) samples collected from a subtropical marine food web in coastal Florida. Methyl paraben (MeP) was found in all abiotic (100%) and a majority of biotic (87%) samples. 4-Hydroxy benzoic acid (4-HB) was the most abundant metabolite, found in 97% of biotic and all abiotic samples analyzed. The food chain accumulation of MeP and 4-HB was investigated for this food web. The trophic magnification factor (TMF) of MeP was estimated to be 1.83, which suggests considerable bioaccumulation and biomagnification of this compound in the marine food web. In contrast, a low TMF value was found for 4-HB (0.30), indicating that this compound is metabolized and excreted along the food web. This is the first study to document the widespread occurrence of parabens and their metabolites in fish, invertebrates, seagrasses, marine macroalgae, mangroves, seawater, and ocean sediments and to elucidate biomagnification potential of MeP in a marine food web.

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Accumulation of 19 environmental phenolic and xenobiotic heterocyclic aromatic compounds in human adipose tissue

Cited by 167 publications

References 42 publications

Estimation of in vivo and in vitro exposure to bisphenol A as food contaminant

Estimation of in vivo and in vitro exposure to bisphenol A as food contaminant

Triclosan-Evoked Neurotoxicity Involves NMDAR Subunits with the Specific Role of GluN2A in Caspase-3-Dependent Apoptosis

Trophic Magnification of Parabens and Their Metabolites in a Subtropical Marine Food Web

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