Accumulation and metabolism of arsenic in mice after repeated oral administration of arsenate

Hughes, Michael F.; Kenyon, Elaina M.; Edwards, Brenda C.; Mitchell, Carol T.; Razo, Luz M. Del; Thomas, David J.

doi:10.1016/s0041-008x(03)00249-7

Cited by 140 publications

(79 citation statements)

References 43 publications

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“…Tumorous and non-tumorous tissue from livers of adult male mice exposed in utero to iAs show aberrant patterns for expression of genes involved in cell differentiation and proliferation . Because arsenicals are cleared from tissues with half times of a few days (Hughes et al, 2003), persistent alterations of gene expression in the tissues of mature mice may reflect changes in gene programming caused by early life exposure to iAs or a metabolite. An altered pattern of methylation of DNA induced by exposure to iAs or a metabolite in utero is one plausible mechanism for an effect on gene expression.…”

Section: Discussionmentioning

confidence: 99%

Arsenicals in maternal and fetal mouse tissues after gestational exposure to arsenite

et al. 2006

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Exposure of pregnant C3H/HeNCR mice to 42.5-or 85-ppm of arsenic as sodium arsenite in drinking water between days 8 and 18 of gestation markedly increases tumor incidence in their offspring. In the work reported here, distribution of inorganic arsenic and its metabolites, methyl arsenic and dimethyl arsenic, were determined in maternal and fetal tissues collected on gestational day 18 of these exposure regimens. Tissues were collected from three females and from associated fetuses exposed to each dosage level. Concentrations of total speciated arsenic (sum of inorganic, methyl, and dimethyl arsenic) were higher in maternal tissues than in placenta and fetal tissues; total speciated arsenic concentration in placenta exceeded those in fetal tissues. Significant dosage-dependent (42.5 ppm versus 85 ppm of arsenite in drinking water) differences were found in total speciated arsenic concentrations in maternal lung (p < 0.01) and liver (p < 0.001). Total speciated arsenic concentrations did not differ significantly between dosage levels for maternal blood or for fetal lung, liver, and blood, or for placenta. Percentages of inorganic, methyl, or dimethyl arsenic in maternal or fetal tissues were not dosage-dependent. Over the range of total speciated arsenic concentrations in most maternal and fetal tissues, dimethyl arsenic was the most abundant arsenical. However, in maternal liver at the highest total speciated arsenic concentration, inorganic arsenic was the most abundant arsenical, suggesting that a high tissue burden of arsenic affected formation or retention of methylated species in this organ. Tissue concentration-dependent processes could affect kinetics of transfer of inorganic arsenic or its metabolites from mother to fetus.

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Section: Discussionmentioning

confidence: 99%

Arsenicals in maternal and fetal mouse tissues after gestational exposure to arsenite

et al. 2006

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“…Animal studies have shown that after administration of iAs, it is distributed to all tissues, with high concentrations in the kidney, lung, urinary bladder, skin, blood and liver [56,57]. Several weeks after administration, As is translocated to hair, nails and skin because of the high affinity of trivalent arsenicals to bind to cystein-components present in the proteins in these tissues [11].…”

mentioning

confidence: 99%

Arsenic in the human food chain, biotransformation and toxicology – Review focusing on seafood arsenic

Molin

Ulven

Meltzer

et al. 2015

Journal of Trace Elements in Medicine and Biology

194

105

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“…ICP-MS analysis of organ samples in our study showed the deposition of As in the above organs, which reflects As toxicity in those organs. Increased kidney weight could result from the methylation of As that was reabsorbed from the renal proximal tubules before it could be excreted in the urine [26]. The liver is known to concentrate As following exposure and play an important role in the metabolism of As, which may induce liver damage, thus identifying this organ as a target for As toxicity [27].…”

Section: Discussionmentioning

confidence: 99%

Immunotoxic and Genotoxic Effects of Arsenic and Ameliorative Potential of Quercetin and Probiotics in Wistar Rat

Alahmari¹

2017

AJLS

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Abstract:Arsenic is a significant environmental public health concern. The aim of the present study is to investigate the possible immunotoxic and genotoxic roles of arsenic and the ameliorative effects of quercetin and probiotics as natural antioxidants. This study was performed on male adult Wistar rats divided into six groups: control, NaAsO 2 -treated, quercetintreated, probiotic-treated, NaAsO 2 and quercetin-treated, and NaAsO 2 and probiotics-treated. Blood samples collected from all animals were prepared for some oxidative, immunological and genetic aspects. Administration of arsenic decreased body and spleen weight, reduced serum antioxidant defense parameters and DNA content, increased liver, kidney, and brain weights, plasma malondialdehyde (MDA), myeloperoxidase (MPO), and serum cytokines (IL-1β, IL-6, TNF-α and IFN-γ). Adding quercetin to arsenic was effective in restoring the altered values of cytokines (IL-1β and IL-6), MPO, MDA, catalase (CAT) and reduced glutathione (GSH) induced by arsenic, whereas the presence of probiotics was effective in reducing genotoxicity and improving the changes of cytokines (TNF-α and IFN-γ) and superoxide dismutase (SOD). Quercetin and probiotics are excellent antioxidant therapies, through their ability to suppress reactive oxygen species ROS production, which may contribute to arsenic toxicity.

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Accumulation and metabolism of arsenic in mice after repeated oral administration of arsenate

Cited by 140 publications

References 43 publications

Arsenicals in maternal and fetal mouse tissues after gestational exposure to arsenite

Arsenicals in maternal and fetal mouse tissues after gestational exposure to arsenite

Arsenic in the human food chain, biotransformation and toxicology – Review focusing on seafood arsenic

Immunotoxic and Genotoxic Effects of Arsenic and Ameliorative Potential of Quercetin and Probiotics in Wistar Rat

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