Accumulation and chemical forms of cadmium and its effect on essential metals in rat spleen and pancreas

Suzuki, Kazuo; Ohnuki, Riko; Yaguchi, Kumiko; Yamada, Yasuko

doi:10.1080/15287398309530380

Cited by 7 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cd in pancreas of rats is generally bound to metallothionein (MT). However, MT in pancreas is extremely susceptible to oxidative reactions as compared to MT in the liver, spleen, and kidneys [13]. Cd toxicity involves the reduction of glutathione and sulfhydryl groups, resulting in the enhanced production of various reactive oxygen species (ROS) such as superoxide ion, hydrogen peroxide, and hydroxyl radicals [14].…”

Section: Introductionmentioning

confidence: 99%

Curcumin Protection Against Cadmium-Induced Oxidative Stress in Pancreas of Swiss Albino Mice

Sharma

Anu

2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: This study was planned to explore the protective efficacy of Curcuma longa (curcumin) against cadmium chloride (CdCl2)-induced oxidative stress in pancreatic tissue of albino mice.Methods: A total of 40 albino mice were equally divided into eight groups (five mice for each). The mice were kept on standard feed and water ad libitum. Control Groups 1 and 5 mice were given equal amount of distilled water, Groups 2 and 6 mice received 1 mg/kg body weight of CdCl2 on alternate days, and Group 3 and 7 received 1 mg/kg body weight of CdCl2 on alternate days and 100 mg/kg body weight of curcumin every day. Groups 4 and 8 received 100 mg/kg body weight of curcumin daily and were kept as positive control. Autopsies were done on 15 and 45 days post-treatment. The pancreas was collected from each mouse and homogenized for biochemical study.Results: The results of the present study revealed that Cd-induced oxidative stress depleted the antioxidant scavenger system and curcumin showed free radical scavenging potential. The activities of antioxidant enzymes, i.e., superoxide dismutase, catalase, glutathione peroxidase were observed to be significantly decreased, and methylenedioxyamphetamine concentration was increased in CdCl2-treated group which was restored to normal level after curcumin treatment.Conclusion: It can be concluded that curcumin acts as a powerful and beneficial antioxidant against oxidative stress by scavenging the free radicals produced by CdCl2.

show abstract

Section: Introductionmentioning

confidence: 99%

Curcumin Protection Against Cadmium-Induced Oxidative Stress in Pancreas of Swiss Albino Mice

Sharma

Anu

2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

show abstract

Effect of diet on urinary and fecal excretion of cadmium, copper, and zinc from rats preaccumulated heavily with cadmium

Suzuki

Miyamoto

Tanaka

et al. 1984

Arch. Environ. Contam. Toxicol.

View full text Add to dashboard Cite

Coaccumulation of Cadmium and Zinc in Tissues of Sentinel Mallards (Anas platyrhynchos) Using a Former Dredge-Disposal Impoundment

Levengood

Skowron

2007

Arch Environ Contam Toxicol

View full text Add to dashboard Cite

Six- to eight-month-old female farm-raised mallards (Anas platyrhynchos) were used to examine the accumulation of and association among cadmium (Cd), zinc (Zn), and copper (Cu) from an impoundment constructed to contain sediments dredged from a lake contaminated by a zinc smelter. Cd was not detectable in the livers t of farm-raised mallards (day 0), although sentinel mallards accumulated hepatic Cd in the first 7 days after release. By day 14, mean concentrations of Cd in kidneys (= 2.82 mg/kg wet weight) had increased 3.4-fold. The mean pancreatic Cd concentration increased 59% between days 7 and 14. Renal Zn increased nominally, whereas pancreatic Zn increased 63% in sentinel ducks after release. Hepatic Zn increased significantly in the first week of release. Renal and pancreatic Cu concentrations did not change significantly, whereas concentrations of Cu in livers of ducks increased 50% in the 7 days after release before decreasing by nearly the same degree. Concentrations of Cd and Zn were correlated in livers of sentinel mallards on days 7 and 14. Cd and Cu were not correlated in the tissues of any cohort. Cu and Zn were correlated in the livers of farm-raised mallards, in the pancreases of sentinel mallards at day 7, and in the kidneys of the ducks in all three treatments. The relationship between Cd and Zn in tissues of ducks in our study was complicated by simultaneous exposure to increased and heterogeneous concentrations of Cd and Zn, both of which can induce metallothionein and compete for this and other ligands.

show abstract

Accumulation and chemical forms of cadmium and its effect on essential metals in rat spleen and pancreas

Cited by 7 publications

References 14 publications

Curcumin Protection Against Cadmium-Induced Oxidative Stress in Pancreas of Swiss Albino Mice

Curcumin Protection Against Cadmium-Induced Oxidative Stress in Pancreas of Swiss Albino Mice

Effect of diet on urinary and fecal excretion of cadmium, copper, and zinc from rats preaccumulated heavily with cadmium

Coaccumulation of Cadmium and Zinc in Tissues of Sentinel Mallards (Anas platyrhynchos) Using a Former Dredge-Disposal Impoundment

Contact Info

Product

Resources

About