Accumulating awareness on the clinical significance and relevance of frailty in cirrhosis: Time to dig deeper into mechanistic basis!

Abstract

Given the multifactorial nature and complex pathogenesis in relation to liver cirrhosis, it is justified to stratify progression risk and to prognosticate mortality in terms of various pathological pertubations alongside laboratory markers. In other words, conventional scoring systems, such as the model for end-stage liver disease (MELD) or Child-Turcotte-Pugh (CTP) classification, may fail to capture specific derangements across multiple physiological pillars, which include but not limited to musculoskeletal, endocrine, neurological,