Accumulated promoter methylation as a potential biomarker for esophageal cancer

Peng, Xiangyu; Xue, Hengchuan; Lu, Lichong; Shi, Peiyi; Wang, Jianping; Wang, Jianming

doi:10.18632/oncotarget.13510

Cited by 26 publications

(18 citation statements)

References 37 publications

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“…The same authors proved that the tumor suppressor miR-101 could reverse the PRDM16 hypomethylation status thus suppressing its expression through direct epigenetic regulation, finally leading to mitochondrial disruption and apoptosis [257]. Similarly, PRDM16 hypomethylation was also described in glioblastoma [258] whereas a study suggested that PRDM16 hypermethylation level might be used as a potential biomarker for the diagnosis of esophageal cancer [259]. Altogether, these findings indicate that PRDM16 methylation status, both hypermethylation and hypomethylation, is often affected in distinct cancers, where this gene can play alternatively a role as an oncogene or as a tumor suppressor gene.…”

Section: Prdm16mentioning

confidence: 95%

Multifaceted Role of PRDM Proteins in Human Cancer

Casamassimi

Rienzo

Zazzo

et al. 2020

IJMS

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The PR/SET domain family (PRDM) comprise a family of genes whose protein products share a conserved N-terminal PR [PRDI-BF1 (positive regulatory domain I-binding factor 1) and RIZ1 (retinoblastoma protein-interacting zinc finger gene 1)] homologous domain structurally and functionally similar to the catalytic SET [Su(var)3-9, enhancer-of-zeste and trithorax] domain of histone methyltransferases (HMTs). These genes are involved in epigenetic regulation of gene expression through their intrinsic HMTase activity or via interactions with other chromatin modifying enzymes. In this way they control a broad spectrum of biological processes, including proliferation and differentiation control, cell cycle progression, and maintenance of immune cell homeostasis. In cancer, tumor-specific dysfunctions of PRDM genes alter their expression by genetic and/or epigenetic modifications. A common characteristic of most PRDM genes is to encode for two main molecular variants with or without the PR domain. They are generated by either alternative splicing or alternative use of different promoters and play opposite roles, particularly in cancer where their imbalance can be often observed. In this scenario, PRDM proteins are involved in cancer onset, invasion, and metastasis and their altered expression is related to poor prognosis and clinical outcome. These functions strongly suggest their potential use in cancer management as diagnostic or prognostic tools and as new targets of therapeutic intervention.

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Section: Prdm16mentioning

confidence: 95%

Multifaceted Role of PRDM Proteins in Human Cancer

Casamassimi

Rienzo

Zazzo

et al. 2020

IJMS

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“…Underlying genetic alterations, including promoter methylation, copy number variations (CNVs) and chromosomal instability (CIN), have been reported to regulate histone modification-associated gene expression. For instance, low PRDM16 expression levels in non-small cell lung cancer and esophageal cancer were reported to be correlated with its promoter methylation (49,50). A high frequency of CNVs at 1p36.32 harboring the PRDM16 gene was observed in GC, suggesting that changes in gene CNVs also have vital roles in regulating gene expression (51).…”

Section: Univariate Analysis Multivariate Analysis ------------------mentioning

confidence: 99%

Comprehensive analysis of histone modification‑associated genes on differential gene expression and prognosis in gastric cancer

et al. 2019

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Accumulating evidence suggests that the epigenetic alterations caused by histone modifications have important roles in the genesis of gastric cancer (GC), particularly the well-studied acetylation and methylation modifications. In the present study, a Bioinformatics analysis of the expression of histone modification-associated genes in GC and normal tissues was performed by using datasets from Oncomine, the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA). The clinical data of GC patients were downloaded from TCGA to determine the association between histone modification-associated gene expression and clinicopathological parameters or survival of GC. Finally, lysine acetyltransferase 2A (KAT2A), nuclear receptor coactivator 1 (NCOA1), SMYD family member 5 (SMYD5), protein arginine methyltransferase 1 (PRMT1) and PRDF1-RIZ (PR)/Su(var)3-9, enhancer-of-zeste and trithorax (SET) domain 16 (PRDM16) were screened; KAT2A, SMYD5 and PRMT1 were upregulated, while PRDM16 expression was downregulated in GC. Analysis of the GEO and Oncomine datasets revealed that NCOA1 was upregulated, which was contrary to the result obtained with the TCGA stomach adenocarcinoma dataset. Aberrant expression of KAT2A, NCOA1, SMYD5 and PRMT1 was more obvious in gastric intestinal-type adenocarcinoma; low NCOA1 expression was associated with better overall survival of GC patients [hazard ratio (HR)=0.690, 95% CI=0.570-0.840, P<0.001] and was an independent predictor for patients diagnosed with GC (HR=0.639, 95% CI=0.437-0.933, P=0.020). Correlation analysis and protein-protein interaction network analysis indicated a close association between ATAD2 and estrogen receptor 1 (ESR1), PRMT1, NCOA1 and KAT2A. In conclusion, differential expression of KAT2A, NCOA1, SMYD5, PRMT1 and PRDM16 was identified in GC vs. normal tissues, low NCOA1 expression was associated with poor survival of GC and ATAD2 may interact with ESR1 to regulate NCOA1 and PRMT1 in GC.

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“…Subsequently, 18 studies were identified for full-text reading. After reading the full-text of the 18 studies, 10 studies were excluded for the following reasons: two were not about cancer [24,25], five did not refer to circulating PTX3 [26][27][28][29][30], two articles did not report the diagnostic performance of circulating PTX3 in cancer detection [31,32], one paper did not present sufficient data [33]. Finally, eight papers involving nine studies were included in this meta-analysis [12][13][14][15][16][34][35][36]].…”

Section: Study Selectionmentioning

confidence: 99%

Pentraxin 3 as a promising biomarker for cancer detection: a systematic review and meta-analysis

Liang

Zhang

Huang

et al. 2019

Preprint

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Background Mounting studies reported that circulating pentraxin 3 (PTX3) expression level was significantly different between cancer patients and healthy groups, suggesting that PTX3 may be a potential biomarker for cancer detection. However, the results were inconsistent. In this paper, a systematic review and meta-analysis was performed to quantitatively assess the diagnostic value of PTX3 in cancer detection.Methods A comprehensive computerized literature search was conducted in Embase, PubMed, Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure (CNKI) from inception to July 31, 2019. Eligible studies were identified and raw data were extracted. Diagnostic estimates were synthesized using STATA (version 12.0) and MetaDisc (version 1.4) statistical software.Results Overall, 9 studies from 8 citations with a total of 1408 cancer patiens and 3116 controls were included in this meta-analysis. The global sensitivity was 0.70 (95% confidence interval (CI): 0.67 – 0.72), and the specificity was 0.77 (95% CI: 0.75 – 0.78). The pooled positive likelihood ratio (PLR), negative likelihood ratio (NLR), and the diagnostic odds ratio (DOR) were 2.86 (95% CI: 2.29 – 3.56), 0.40 (95% CI: 0.32 – 0.50) and 7.38 (95% CI: 5.05 – 10.78), respectively. The merged AUC was 0.80 (95% CI: 0.76 – 0.83).Conclusion The serum PTX3 appears to be a reliable biomarker for cancer detection though large-scale multicenter studies are needed.

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Accumulated promoter methylation as a potential biomarker for esophageal cancer

Cited by 26 publications

References 37 publications

Multifaceted Role of PRDM Proteins in Human Cancer

Multifaceted Role of PRDM Proteins in Human Cancer

Comprehensive analysis of histone modification‑associated genes on differential gene expression and prognosis in gastric cancer

Pentraxin 3 as a promising biomarker for cancer detection: a systematic review and meta-analysis

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