Accumlation of Acetone in Blood During Long-Term Anaesthesia With Closed Systems

Straub, Josef; Hausdörfer, J.

doi:10.1093/bja/70.3.363

Cited by 15 publications

(5 citation statements)

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“…Accumulation of acetone in blood and in breath is common in diabetes, in patients during anesthesia or surgical stress. Other factors such as body weight, age, and especially alcoholism influence the resting blood concentration of acetone 39 . Higher acetone, 3-hydroxybutyrate, and acetate levels have been described also in blood samples from patients with other neurodegenerative diseases, such as multiple sclerosis 40 and amyotrophic lateral sclerosis 41 .…”

Section: Discussionmentioning

confidence: 99%

Metabolite and lipoprotein profiles reveal sex-related oxidative stress imbalance in de novo drug-naive Parkinson’s disease patients

Tenori

Schade

Licari

et al. 2022

npj Parkinsons Dis.

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Parkinson’s disease (PD) is the neurological disorder showing the greatest rise in prevalence from 1990 to 2016. Despite clinical definition criteria and a tremendous effort to develop objective biomarkers, precise diagnosis of PD is still unavailable at early stage. In recent years, an increasing number of studies have used omic methods to unveil the molecular basis of PD, providing a detailed characterization of potentially pathological alterations in various biological specimens. Metabolomics could provide useful insights to deepen our knowledge of PD aetiopathogenesis, to identify signatures that distinguish groups of patients and uncover responsive biomarkers of PD that may be significant in early detection and in tracking the disease progression and drug treatment efficacy. The present work is the first large metabolomic study based on nuclear magnetic resonance (NMR) with an independent validation cohort aiming at the serum characterization of de novo drug-naive PD patients. Here, NMR is applied to sera from large training and independent validation cohorts of German subjects. Multivariate and univariate approaches are used to infer metabolic differences that characterize the metabolite and the lipoprotein profiles of newly diagnosed de novo drug-naive PD patients also in relation to the biological sex of the subjects in the study, evidencing a more pronounced fingerprint of the pathology in male patients. The presence of a validation cohort allowed us to confirm altered levels of acetone and cholesterol in male PD patients. By comparing the metabolites and lipoproteins levels among de novo drug-naive PD patients, age- and sex-matched healthy controls, and a group of advanced PD patients, we detected several descriptors of stronger oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Metabolite and lipoprotein profiles reveal sex-related oxidative stress imbalance in de novo drug-naive Parkinson’s disease patients

Tenori

Schade

Licari

et al. 2022

npj Parkinsons Dis.

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“…Frequent flushing of the system with high fresh gas flows to remove foreign gases partially offsets the advantages of the minimal flow technique. Flushing of the anaesthesia circuit rapidly removes nitrogen and methane from the system [13], but does not decrease blood concentrations of acetone during long-term closed-circuit anaesthesia [14]. At present it is not known if blood concentrations of acetone increase during minimal flow anaesthesia.…”

Section: Discussionmentioning

confidence: 96%

“…Accumulation of nitrogen causes dilution of oxygen and anaesthetic agents. High blood concentrations of acetone after long-term closedcircuit anaesthesia increase the incidence of postoperative nausea and vomiting [14]. Methane accumulation can disturb infrared analysis of volatile anaesthetics [15].…”

Section: Discussionmentioning

confidence: 99%

Fuzzy logic control of inspired isoflurane and oxygen concentrations using minimal flow anaesthesia

Curatolo

Derighetti

Petersen-Felix

et al. 1996

British Journal of Anaesthesia

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SummaryIn order to evaluate the performance of feedback fuzzy logic control of inspired oxygen and isoflurane concentrations, we studied 30 patients undergoing discectomy for lumbar (n : 26) or cervical (n : 4) disc herniation. Patients were allocated random to one of two groups: a standard group (n : 15) with low flow anaesthesia (1.2-1.3 litre min 91 ) and manual control of gas concentrations and a fuzzy group (n : 15) with minimal flow (0.5 litre min 91 ) and fuzzy logic feedback control of gas concentrations. Fuzzy logic control achieved and maintained very accurately the desired isoflurane concentration. Oxygen concentration was controlled more precisely than in the standard group. Delivery and costs of oxygen and nitrous oxide were significantly lower in the fuzzy group (P : 0.01). Accumulation of foreign gases was observed in one patient during low flow and in 11 patients during minimal flow anaesthesia. In conclusion, fuzzy logic control of inspired oxygen and isoflurane concentration during minimal flow anaesthesia was reliable and reduced anaesthetic gas delivery and costs. (Br.

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“…The common intoxicant ethanol, can also accumulate. 33,34 c. Compound A: It is accepted that prolonged sevoflurane anesthesia with low fresh gas flows results in proteinuria, glycosuria, and enzymuria. However, this is not, and has not been shown to be, associated with any clinical manifestations, even when such a technique is applied to patients with pre-existing biochemical renal abnormalities.…”

Section: A Carbon Monoxidementioning

confidence: 99%

Low Flow Anaesthesia

Awati¹,

Patil²,

Fathima³

et al. 2014

jebmh

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Modern inhalational anaesthetic agents are metabolized to a small extent only and are largely exhaled unchanged. The use of closed system with carbon dioxide absorption units and comprehensive gas monitoring permits the exploitation of this to perform economical and safe "low-flow anaesthesia". Modern equipment permits the further reduction of the carrier gas flow to the ultimate degree of providing the patient"s requirements. This article describes the principles of Low flow anaesthesia, its advantages & disadvantages.

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Accumlation of Acetone in Blood During Long-Term Anaesthesia With Closed Systems

Cited by 15 publications

References 0 publications

Metabolite and lipoprotein profiles reveal sex-related oxidative stress imbalance in de novo drug-naive Parkinson’s disease patients

Metabolite and lipoprotein profiles reveal sex-related oxidative stress imbalance in de novo drug-naive Parkinson’s disease patients

Fuzzy logic control of inspired isoflurane and oxygen concentrations using minimal flow anaesthesia

Low Flow Anaesthesia

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