“…Work by one of us (LJW) indicates these antibodies might recognize determinants not present in the graft and hence are not subject to the processes that engender tolerance (69). On the other hand, as we discuss in detail elsewhere (62, 71, 72), absence of antibodies in serum against donor antigens, particularly blood group antigens cannot be taken as proof of tolerance because organ transplants can absorb enormous amount of antibody when accommodation is present. To the extent such absorption occurs, donor-specific antibodies, against blood group antigens or HLA, might be detected after graft injury compromises the ability of a graft to process bound antibodies (62, 71).…”