The current pandemic, novel corona virus 19 disease (COVID-19), has created havoc across the world. Now a third wave is possible, and we have already crossed two waves. The current review article presents recent reports about the COVID-19, the ways of treatments, and prevention. In view of the potential threats of a pandemic, various scientists have been trying to understand the pathophysiology of this disease to uncover possible treatment regimens and discover effective therapeutic agents and vaccines. To add further information to support the ongoing current research and development against SARS-CoV-2, the authors have provided the basics of pathophysiology, possible targets, and current treatment strategy for corona viruses. The current review highlights the antiviral strategies involving small molecules and different biological targets involved in corona virus infection and replication. The information included in this article provides a strong intellectual foundation for the ongoing development of therapeutic agents and vaccines.