Acclimatization to High Altitude in the Tien Shan: A Comparative Study of Indians and Kyrgyzis

Basu, C. K.; Banerjee, P. K.; Selvamurthy, W.; Sarybaev, A. Sh.; Миррахимов, М М

doi:10.1580/06-weme-or-025r1.1

Cited by 9 publications

(14 citation statements)

References 13 publications

(26 reference statements)

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“…; Basu et al. ). Rather, we argue that it may be clearer to first decide whether gas compression artifact and/or air‐density dependence is likely to affect the data at hand and, if so, take pains to adjust for their influence.…”

Section: Discussionmentioning

confidence: 97%

“…; Basu et al. ): that is, 1.61 ½ = 1.27. Consequently, for a constant airway caliber ( A ) and airway wall elasticity ( E ), one may expect FEFs to increase by roughly 30% upon ascent from Moshi to Barafu camp.…”

Section: Discussionmentioning

confidence: 99%

“…; Basu et al. ) depending on the lung volume considered (i.e., peak vs. mid‐expiratory flows, etc.). It is relevant to note that these studies differed on the bases of altitude exposure, subject demographics and history of high‐altitude pulmonary edema, baseline pulmonary disease status, and location (i.e., hypobaric chamber vs. field‐based expeditions).…”

Section: Introductionmentioning

confidence: 99%

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The influence of thoracic gas compression and airflow density dependence on the assessment of pulmonary function at high altitude

et al. 2018

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The purpose of this report was to illustrate how thoracic gas compression (TGC) artifact, and differences in air density, may together conflate the interpretation of changes in the forced expiratory flows (FEFs) at high altitude (>2400 m). Twenty‐four adults (10 women; 44 ± 15 year) with normal baseline pulmonary function (>90% predicted) completed a 12‐day sojourn at Mt. Kilimanjaro. Participants were assessed at Moshi (Day 0, 853 m) and at Barafu Camp (Day 9, 4837 m). Typical maximal expiratory flow‐volume (MEFV) curves were obtained in accordance with ATS/ERS guidelines, and were either: (1) left unadjusted; (2) adjusted for TGC by constructing a “maximal perimeter” MEFV curve; or (3) adjusted for both TGC and differences in air density between altitudes. Forced vital capacity (FVC) was lower at Barafu compared with Moshi camp (5.19 ± 1.29 L vs. 5.40 ± 1.45 L, P < 0.05). Unadjusted data indicated no difference in the mid‐expiratory flows (FEF 25–75%) between altitudes (∆ + 0.03 ± 0.53 L sec−1; ∆ + 1.2 ± 11.9%). Conversely, TGC‐adjusted data revealed that FEF 25–75% was significantly improved by sojourning at high altitude (∆ + 0.58 ± 0.78 L sec−1; ∆ + 12.9 ± 16.5%, P < 0.05). Finally, when data were adjusted for TGC and air density, FEFs were “less than expected” due to the lower air density at Barafu compared with Moshi camp (∆–0.54 ± 0.68 L sec−1; ∆–10.9 ± 13.0%, P < 0.05), indicating a mild obstructive defect had developed on ascent to high altitude. These findings clearly demonstrate the influence that TGC artifact, and differences in air density, bear on flow‐volume data; consequently, it is imperative that future investigators adjust for, or at least acknowledge, these confounding factors when comparing FEFs between altitudes.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The influence of thoracic gas compression and airflow density dependence on the assessment of pulmonary function at high altitude

et al. 2018

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“…A very small portion of the people suffering from HAPE in the same population were observed to migrate to a plateau region (Rupert and Koehle, 2006). Tibetans show greater adaptability to the hypoxic environment of high-altitude regions compared to people belonging to the Han ethnicity; the incidence of HAPE was significantly less in Tibetans compared to that observed in people belonging the Han ethnicity (Cheng et al, 1997;Basu et al, 2007). Genetic factors accounted for approximately 50% of the factors influencing the adaptation of the human body to highaltitude hypoxic environments (Wu et al, 2005;Wu and Kayser, 2006).…”

Section: Discussionmentioning

confidence: 99%

Correlation between single nucleotide polymorphisms in hypoxia-related genes and susceptibility to acute high-altitude pulmonary edema

Al¹,

Ys²,

Zq³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. This study aimed to explore the relationship between genetic changes and high-altitude pulmonary edema (HAPE) susceptibility, and to screen for the key single nucleotide polymorphism (SNP) loci in the HAPE-susceptibility gene, by investigating the SNPs occurring in hypoxia-related genes in HAPE-susceptible and control (non-susceptible) populations. This research was conducted on Han recruits, who travelled to the Lhasa plateau (altitude, 3658 m). Ten loci located on ten genes extracted from the HAPE and healthy populations were amplified by polymerase chain reaction, and subsequently sequenced. The investigated genes included those coding for aldosterone synthase 2 (CYP11B2), angiotensin-converting enzyme (ACE), heat-shock protein 70 (HSP70), nuclear factor kappa B (NF-κB), surfactant protein A2 (SP-A2), plasminogen activator inhibitor-1 (PAI-1), nitric oxide synthetase (NOS), vascular endothelial growth factor (VEGF), prolyl hydroxylase (EGLN1), and zinc finger protein A20. The gene distribution of each SNP loci and its correlation with (2015) HAPE was analyzed. Statistical analyses of the genotype frequencies of the SNPs revealed significant differences in the ACE (rs4309), EGLN1 (rs480902), SP-A2 (rs1965708), HSP70 (rs1008438), PAI-1 (rs1799889), and NOS (rs199983) expressions between the HAPE and healthy control groups (P < 0.05); therefore, these SNP loci were believed to indicate HAPE susceptibility. HAPE is correlated with multiple-SNP loci. A correlation analysis between genetic polymorphism and HAPE susceptibility revealed that 6 hypoxia-related genes were key sites accounting for HAPE. These findings could help assess the risk of HAPE in populations expressing different genotypes, in order to reduce the occurrence of HAPE.

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“…Esta disminución de la presión parcial del oxígeno en el aire genera hipoxia hipóbarica (PATITUCCI et al, 2009). Al producirse estos cambios, los tejidos no reciben las cantidades de oxígeno requeridas para los procesos del metabolismo, por lo cual, el organismo genera estrategias de compensación de manera aguda y si la hipoxia es mantenida en el tiempo -meses, años, generaciones-se generan adaptaciones crónicas (BASU et al, 2007). Ante esta circunstancia la disminución en la presión arterial de oxígeno en el riñón es registrada por las células intersticiales, lo que contribuye a la estimulación de la producción de eritropoyetina.…”

Section: Discussionunclassified

Perfil hematológico del burro criollo (Equus asinus) colombiano

Pinto

2017

Rev Colombiana Cienc Anim. RECIA

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The diagnosis of diseases in animals depends to a large extent on clinical examinations and laboratory results, in which biological variations are reflected. The hematological values are very important for the evaluation of the normal physiological state of an animal. However, very few works have been carried out in this respect on creole asses. The objective of this investigation was to determine the mean values of a hemogram for creoles donkeys of the Colombian lowland. A cross -sectional descriptive study was performed with a non -probabilistic sample for convenience. Samples of 85 male donkeys between 4 and 15 years old were clinically healthy and fed with Brachiaria humidicula pastures. These parameters were obtained by means of a hematological analyzer (ABX Micros ESV 60). The values obtained were: leukocytes 7.6±1.6 x10 3

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Acclimatization to High Altitude in the Tien Shan: A Comparative Study of Indians and Kyrgyzis

Abstract: The major difference between the 2 populations was larger lung volumes in the Kyrgyzis compared with the Indians, with no differences seen in their flow rate measures. Also, there was a different time schedule of altitude-induced reductions in FVC and FEF(25-75%).

Cited by 9 publications

References 13 publications

The influence of thoracic gas compression and airflow density dependence on the assessment of pulmonary function at high altitude

The influence of thoracic gas compression and airflow density dependence on the assessment of pulmonary function at high altitude

Correlation between single nucleotide polymorphisms in hypoxia-related genes and susceptibility to acute high-altitude pulmonary edema

Perfil hematológico del burro criollo (Equus asinus) colombiano

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