. Administration of antirheumatic drugs. A study of 200 rheumatic patients attending an outpatient clinic and 72 general practitioners (GPs) was undertaken in relation to the administration of antirheumatic drugs. (1) Both patients and GPs agreed that effectiveness, absence of toxicity, and once daily administration were the important features of administration. (2) Significant differences between GPs and patients were noted in that patients more frequently preferred capsules than tablets. (3) GPs thought red was the best colour for an antirheumatic tablet, whereas patients thought white, this opinion being partly determined by the possible confusion ofred tablets with sweets by children. (4) There are good reasons to believe that patients with rheumatic disorders do not take the regimen of medication at home prescribed by their physicians (Sasisekhar and others, 1973). It may well be that the mode of administration of antirheumatic drugs influences the regularity of taking them at home, but little is known about the problems patients experience. Moreover, there is evidence that presentation of the preparation (e.g. its colour and shape) may influence the response of patients (Schapira and others, 1970;Schiff, Murphy, and Anderson, 1975;Huskisson, 1974). Since few data are available on this problem, the present study was undertaken to ascertain important factors in drug administration from the views of patients and general practitioners.Material and methods 200 rheumatic patients attending the Rheumatology Out-Patient Clinic at Leeds answered a questionnaire about the features of antirheumatic medication they considered desirable in terms of the effect, cost, presentation, mode, and frequency of administration of the drug, scoring each attribute from 0 to 10. They were then asked the colour of the tablet for the antirheumatic preparation they considered to be most valuable. Finally, they were asked to place in a ranking order the four attributes they considered most important. An identical questionnaire was answered by 72 general practitioners (GPs) attending small group seminars in the area.In a separate study 174 outpatients were questioned about the use of blister packs as a means of packaging antirheumatic drugs. A further 30 patients with rheumatoid arthritis in hospital were studied to ascertain the ease with which they could manipulate two types of blister packs: one containing aspirin enseals and the other containing oxyphenonium (a smaller tablet).
ResultsThe mean scores of patients and GPs are shown in Table I. Statistically significant differences were found between the scores of GPs and patients for once daily administration, solubility, and presentation by capsules, tablets, and suppositories. Scores of over 65 % were taken to indicate attributes of major importance. Both patients and GPs agreed on effectiveness, absence of toxicity, and once daily administration. However, patients thought that capsule presentation was also important, whereas GPs felt that palatability, cheapness, and twice daily ...