Accidental Modopar^© Poisoning in a Two-Year-Old Child: A Case Report

Abstract

Levodopa is a dopamine precursor and a mainstay treatment in the management of Parkinson’s disease. Its side effects induce dyskinesia, nausea, vomiting, and orthostatic hypotension. Acute levodopa acute poisoning is uncommon, with only a few reported cases in the medical literature. Treatment of poisoning by levodopa is mainly supportive. The case of a child admitted to a hospital for acute levodopa poisoning is presented in this report.

Poisoning After Ingestion of Mucuna pruriens Seeds on Reunion Island

“…These symptoms can be induced by levodopa; the same symptoms are currently noted with drugs used to treat Parkinson's disease. [13][14][15][16] Digestive disorders can also be induced by other antinutritional toxins, such as tannins and saponins. In 1989, an outbreak of acute poisoning after M pruriens ingestion in Mozambique was reported.…”

Acute Movement Disorders in Childhood

“…Chorea and dyskinesia may be acutely induced in children by other psychostimulants [ 163 ], ACTH, vigabatrin, theophylline, aminophylline, midazolam, phenytoin and other anticonvulsants [ 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 ], as well as by the rapid discontinuation of intravenous midazolam [ 173 , 174 ]. Although better reported in adults, anticholinergics, L-DOPA, dopamine-agonists, opioids, TCAs, baclofen and lithium may also cause chorea [ 16 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 ]. Oral contraceptives may cause chorea in adolescent girls, especially in patients with previous SC [ 183 , 184 ].…”