Accidental Doxorubicin Overdosage

Evaluating the Effect of Micropump© Position, Internal Pressure and Doxorubicin Dosage on Efficacy of Pressurized Intra-peritoneal Aerosol Chemotherapy (PIPAC) in an Ex Vivo Model

“…Therefore, higher local doxorubicin dosage or closer distance to peritoneum or bowel and higher tissue uptake might lead to higher local toxicity, such as perforation, ileus or local tissue necrosis. Presumably, with a higher tissue uptake of doxorubicin a higher systemic uptake of the drug might occur, which can lead to the incidence of known side-effects of systemic application of doxorubicin (18,19). The total applied dose during PIPAC is approximately 10% of a usual systemic chemotherapy (13).…”

Medication Errors: Causes, Prevention and Reduction

“…There are several case reports in the literature describing fatal overdoses of drugs commonly used during haematology/oncology treatment, including doxorubicin (Edgar et al , 1994; Back et al , 1995), cisplatin (Chu et al , 1993; Edgar et al , 1994), vinblastine (Conter et al , 1991) and vincristine (Kosmidis et al , 1991; Stones, 1998). Other case reports describe the toxicity‐induced death of patients when vincristine has been administered intrathecally (Manelis et al , 1982; Jackson & Hassan, 1997; Michelagnoli et al , 1997; Fernandez et al , 1998) or when a vaguely written prescription has been misinterpreted by the person responsible for administering the drug.…”

Toxicity, outcome, and management of anthracycline overdoses in 16 dogs

“…10 , 11 , 12 , 13 At established dosages, anthracyclines are generally well‐tolerated in both humans and dogs, with dose limiting toxicities including myelosuppression, gastrointestinal (GI) abnormalities, and anorexia. 14 , 15 , 16…”

“…No cardiac dysfunction was observed and with supportive care both patients recovered within 18‐26 days, despite prolonged myelotoxicity. 14 …”