Accidental death from a fall from height at workplace turned out to be a COVID-19 death

Puzović, Velibor; Baković, Marija; Bubalo, Pero; Mayer, Davor

doi:10.1016/j.fsir.2020.100139

Cited by 4 publications

(2 citation statements)

References 16 publications

(32 reference statements)

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“…Organizing DAD can also begin to show areas of loose interstitial fibrosis along with intra-alveolar fibrin and inflammatory infiltrates [ 60 ]. Few studies have been able to study the early effects of COVID-19 or effects of the disease not complicated by medical treatment, reporting similar microscale structural changes to those of patient cohorts with various comorbidities, medical treatments, and prolonged disease courses [ [61] , [62] , [63] , [64] , [65] , [66] ].…”

Section: Resultsmentioning

confidence: 99%

Implications of microscale lung damage for COVID-19 pulmonary ventilation dynamics: A narrative review

et al. 2021

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The COVID-19 pandemic surges on as vast research is produced to study the novel SARS-CoV-2 virus and the disease state it induces. Still, little is known about the impact of COVID-19-induced microscale damage in the lung on global lung dynamics. This review summarizes the key histological features of SARS-CoV-2 infected alveoli and links the findings to structural tissue changes and surfactant dysfunction affecting tissue mechanical behavior similar to changes seen in other lung injury. Along with typical findings of diffuse alveolar damage affecting the interstitium of the alveolar walls and blood-gas barrier in the alveolar airspace, COVID-19 can cause extensive microangiopathy in alveolar capillaries that further contribute to mechanical changes in the tissues and may differentiate it from previously studied infectious lung injury. Understanding microlevel damage impact on tissue mechanics allows for better understanding of macroscale respiratory dynamics. Knowledge gained from studies into the relationship between microscale and macroscale lung mechanics can allow for optimized treatments to improve patient outcomes in case of COVID-19 and future respiratory-spread pandemics.

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Section: Resultsmentioning

confidence: 99%

Implications of microscale lung damage for COVID-19 pulmonary ventilation dynamics: A narrative review

et al. 2021

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“…For this reason, it is fundamental to remark that before sending alarming massages, the forensic community is called on to fully comprehend the weight of the evidence. It is important to highlight that the lessons learned from this review urge all the personnel involved in autopsies (technicians, biologists, pathologists) to take into account the presence of SARS-CoV-2 in all suspected deaths during the pandemic, wearing appropriate personal protective equipment adopting the suggested procedure to perform autopsy safely [ 53 , 148 ]. At the same time, the value of the autopsy in the management of unknown diseases is indisputable.…”

Section: Discussionmentioning

confidence: 99%

Autopsy Tool in Unknown Diseases: The Experience with Coronaviruses (SARS-CoV, MERS-CoV, SARS-CoV-2)

2021

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In the last two decades, three unknown pathogens have caused outbreaks, generating severe global health concerns. In 2003, after nucleic acid genotyping, a new virus was named severe acute respiratory syndrome coronavirus (SARS-CoV). After nine years, another coronavirus emerged in the middle east and was named MERS-CoV (Middle East Respiratory Syndrome—Coronavirus). Finally, in December 2019, a new unknown coronavirus was isolated from a cluster of patients and was named SARS-CoV-2 (COVID-19, coronavirus disease 2019). This review aims to propose a complete overview of autopsy in the three coronaviruses over the past two decades, showing its pivotal role in the management of unknown diseases. A total of 116 studies fulfilled the inclusion criteria: 14 studies were collected concerning SARS-CoV (87 autopsy reports, from Asian and American countries), 2 studies for MERS-CoV (2 autopsy reports, from Middle-East Asian countries), and 100 studies on SARS-CoV-2 (930 autopsy reports). Analyzing the data obtained on COVID-19, based on the country criterion, a large number of post-mortem investigation were performed in European countries (580 reports), followed by American countries (251 reports). It is interesting to note that no data were found from the Oceanic countries, maybe because of the minor involvement of the outbreak. In all cases, autopsy provided much information about each unknown coronavirus. Despite advanced technologies in the diagnostic fields, to date, autopsy remains the gold standard method to understand the biological features and the pathogenesis of unknown infections, especially when awareness of a pathogen is restricted and the impact on the healthcare system is substantial. The knowledge gained through this technique may positively influence therapeutic strategies, ultimately reducing mortality.

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Postmortale Infektionsdiagnostik

Preuß-Wössner,

Basner

2023

Rechtsmedizin

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Accidental death from a fall from height at workplace turned out to be a COVID-19 death

Cited by 4 publications

References 16 publications

Implications of microscale lung damage for COVID-19 pulmonary ventilation dynamics: A narrative review

Implications of microscale lung damage for COVID-19 pulmonary ventilation dynamics: A narrative review

Autopsy Tool in Unknown Diseases: The Experience with Coronaviruses (SARS-CoV, MERS-CoV, SARS-CoV-2)

Postmortale Infektionsdiagnostik

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